Mild Cognitive Impairment Clinical Trials

86 studies are recruiting for mild cognitive impairment in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

   Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective: To learn wh…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04396873 on ClinicalTrials.gov

2. PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

   Background: About 5 million adults in the United States have age-related brain disorders. These include Alzheimer disease (AD), mild cognitive impairment (MCI), and other dementias. The number of people with these disorders will likely increase as the population ages and life span increases. Inflam…

   Stage

   Phase 1

   Ages

   50 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT07169630 on ClinicalTrials.gov

3. Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

   The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Barrow Neurological Institute, Phoenix, Arizona

   Locations

   31 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT04916210 on ClinicalTrials.gov

4. Study to Understand Novel Biomarkers in Researching Dementia

   The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and pr…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06547099 on ClinicalTrials.gov

5. Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

   The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.

   Stage

   Not phased

   Ages

   55 and older

   Site

   Georgetown University, Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   Columbia University

   See if you can join NCT05655325 on ClinicalTrials.gov

6. Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

   The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are t…

   Stage

   Not phased

   Ages

   70 and older

   Site

   Saddleback Medical Center, Orange, California

   Locations

   7 in total

   Run by

   University of Michigan

   See if you can join NCT05929703 on ClinicalTrials.gov

7. Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

   This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve qual…

   Stage

   EARLY_Phase 1

   Ages

   18 to 85

   Site

   Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT04123314 on ClinicalTrials.gov

8. OTC Hearing Aid and MCI

   The goal of this study is to better understand if, in patients with mild to moderate hearing loss who are also experiencing mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (ADRD), Over-the-Counter (OTC) hearing aids: 1. improve communication 2. Whether the magnitude of …

   Stage

   Not phased

   Ages

   60 to 90

   Site

   Northwestern University HA Lab, Evanston, Illinois

   Locations

   3 in total

   Run by

   Northwestern University

   See if you can join NCT06112860 on ClinicalTrials.gov

9. Olfactory Training in Mild Cognitive Impairment

   Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline. Memory for new odors is particularly diminished in these individuals. Existing treatments for AD do not improve these symptoms. A targeted…

   Stage

   Not phased

   Ages

   55 to 89

   Site

   New York State Psychiatric Institute, New York, New York

   Run by

   Jeffrey Motter

   See if you can join NCT06825403 on ClinicalTrials.gov

10. ADRC Clinical Cohort (Alzheimer's Disease)

    The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment…

    Stage

    Not phased

    Ages

    25 to 80

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06703541 on ClinicalTrials.gov

11. Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline

    The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment. The main questions it aims to answer are: * whether it is possible to restore various cognitive functions in …

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Health Discovery Building, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05907343 on ClinicalTrials.gov

12. Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment

    The purpose of this study is to demonstrate feasibility, usability, and acceptability of virtual reality (VR)-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognit…

    Stage

    Not phased

    Ages

    55 to 90

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT07638748 on ClinicalTrials.gov

13. Microbiome in Aging of Gut and Brain

    The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline. The study includes young healthy adults, cognitively healthy older adul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07799402 on ClinicalTrials.gov

14. Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

    This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

    Stage

    Not phased

    Ages

    30 to 90

    Site

    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

    Run by

    VA Office of Research and Development

    See if you can join NCT04124029 on ClinicalTrials.gov

15. MCI Speech in Noise

    The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, w…

    Stage

    Not phased

    Ages

    55 to 80

    Site

    Space Medicine Lab at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06102486 on ClinicalTrials.gov

16. Senicapoc in Alzheimer's Disease

    Development of novel disease-modifying therapies for Alzheimer's disease (AD) remains of paramount importance. This study will be a Phase II randomized clinical trial testing Senicapoc in patients with mild or prodromal AD. This will be a small Proof of Mechanism study to prove biological activity …

    Stage

    Phase 2

    Ages

    55 to 85

    Site

    University of California, Davis Alzheimer's Disease Center, Sacramento, California

    Locations

    2 in total

    Run by

    University of California, Davis

    See if you can join NCT04804241 on ClinicalTrials.gov

17. The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

    The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction. The main question[s] it aims to answer are: * To compare vascular function, oxidative stress levels, and physical and cognit…

    Stage

    Phase 2

    Ages

    65 to 80

    Site

    UConn Health, Farmington, Connecticut

    Run by

    UConn Health

    See if you can join NCT06027554 on ClinicalTrials.gov

18. Neuromodulation of Memory in Aging

    The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study ne…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Duke University Hospital, Durham, North Carolina

    Run by

    Indiana University

    See if you can join NCT05460468 on ClinicalTrials.gov

19. Autoimmune Features of Neurodegenerative Disorders

    This study is being conducted to better understand the role of inflammation in Parkinson's disease (PD) and Alzheimer's disease (AD). The investigators plan to recruit 30 PD, 30 AD/Amnestic Mild Cognitive Impairment (aMCI), and 60 age matched healthy controls in this study to study the role of immu…

    Stage

    Not phased

    Ages

    55 to 90

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04239079 on ClinicalTrials.gov

20. Improve New Learning and Memory in Individuals With Mild Cognitive Impairment

    The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in individuals with Mild Cognitive Impairment (MCI). Impairment in higher level cognitive processing, such as new learning and memory, is one of the most common deficits in ind…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    Kessler Foundation

    See if you can join NCT05396248 on ClinicalTrials.gov

21. Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

    This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those…

    Stage

    Phase 2

    Ages

    55 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05446584 on ClinicalTrials.gov

22. A Feasiblity Study of Green Activity Program for People Living With Memory Challenges

    The purpose of this study is to test the Green Activity Program that was designed with people living with memory challenges and their study partners to see if it can be done and if they enjoy the program. "Green activities" are nature activities that the person enjoys and can be done with other peo…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Indiana University Bloomington, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT06403345 on ClinicalTrials.gov

23. Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

    The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and c…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    Massachusetts General Hospital, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05904132 on ClinicalTrials.gov

24. Superior Parietal iTBS for PD-MCI

    The goal of this study is to determine the whether a short-term, high-dose form of non-invasive brain stimulation (intermittent theta burst stimulation; iTBS) is a promising and safe treatment for mild cognitive impairment in Parkinson's disease (PD-MCI).

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07701785 on ClinicalTrials.gov

25. Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)

    CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease. This single-site (Baltimore, Maryland) phase II clinical trial is a 2-week, randomized, placebo-controlled crossover study of …

    Stage

    Phase 2

    Ages

    55 and older

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04601038 on ClinicalTrials.gov