Malignant Solid Neoplasm Clinical Trials

93 studies are recruiting for malignant solid neoplasm in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

   This phase II ComboMATCH treatment trial compares the effect of neratinib to the combination of neratinib and palbociclib in treating patients with HER2 positive solid tumors. Neratinib and palbociclib are in a class of medications called kinase inhibitors. They work by blocking the action of an ab…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

   Locations

   194 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06126276 on ClinicalTrials.gov

2. Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

   This study collects research data and samples from patients who experience immunotherapy side effects to store for use in future research studies. Studying research data and samples from patients who experience immunotherapy side effects may help researchers better understand how to predict, preven…

   Stage

   Not phased

   Ages

   Any age

   Site

   Anchorage Associates in Radiation Medicine, Anchorage, Alaska

   Locations

   625 in total

   Run by

   Alliance for Clinical Trials in Oncology

   See if you can join NCT04242095 on ClinicalTrials.gov

3. Different Types of Massage Therapy to Reduce Anxiety During Chemotherapy Infusion in Patients With Cancer

   This clinical trial tests how well different types of massage therapy works to reduce anxiety during chemotherapy infusions in patients with cancer. Many cancer patients experience moderate to severe anxiety and anxiety can worsen by the anticipation of medical procedures that patients have to rece…

   Stage

   Not phased

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Run by

   City of Hope Medical Center

   See if you can join NCT07184294 on ClinicalTrials.gov

4. Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

   This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California Davis Comprehensive Cancer Center, Sacramento, California

   Locations

   52 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03816345 on ClinicalTrials.gov

5. Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure

   This randomized clinical trial studies how well non-invasive ventilation works in reducing the need for intubation, or placement of a tube in the windpipe, in patients with cancer and respiratory failure. Respiratory failure is a condition in which not enough oxygen passes from the lungs to the blo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT02464696 on ClinicalTrials.gov

6. A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

   This study is being done to establish "normal' values for a new blood test and urine test approach to cancer screening. Patients undergo blood and urine sample collection on study. Patients' medical records are reviewed.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06192875 on ClinicalTrials.gov

7. Testing an Educational Program to Improve Goals of Care Conversations Between Patients and Their Care Teams

   This clinical trial evaluates an educational program called Algorithm-Enabled Patients Activated in Cancer Care Through Teams (A-PACT) for reducing unplanned hospital visits and improving goals of care conversations with providers among patients with solid cancers. A-PACT is an educational program …

   Stage

   Not phased

   Ages

   18 and older

   Site

   CARTI Cancer Center, Little Rock, Arkansas

   Run by

   SWOG Cancer Research Network

   See if you can join NCT07278739 on ClinicalTrials.gov

8. Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

   In this clinical trial, symptom monitoring (interactive voice response [IVR] is compared to automated telephone symptom management [ATSM] and telephone interpersonal counseling [TIPC]) for reducing symptom burden and psychological distress (depressive and anxiety symptoms) among people receiving or…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cancer Center at Saint Joseph's, Phoenix, Arizona

   Locations

   34 in total

   Run by

   NRG Oncology

   See if you can join NCT06279013 on ClinicalTrials.gov

9. Observational Study of Sex Differences in Symptoms During Immune Checkpoint Inhibitor Treatment for People With Cancer

   This study aims to learn more about symptoms that patients experience while receiving immunotherapy for cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   OHSU Knight Cancer Institute, Portland, Oregon

   Run by

   OHSU Knight Cancer Institute

   See if you can join NCT06562777 on ClinicalTrials.gov

10. Community Enhanced Virtual Informed Consent

    The goal of this clinical trial is to examine perceptions of virtual human communicators and cancer research recruitment messages. This study will also examine how different informed consent approaches influence decisions to participate in research.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT07805083 on ClinicalTrials.gov

11. A Pilot Unrestricted Payment Program for Early-stage Cancer Patients: the PAYMENT Trial

    This clinical trial studies whether an unrestricted cash payment program can be used to improve financial and clinical outcomes in early-stage cancer patients with financial concerns. A cancer diagnosis can have poor financial outcomes, and the cost of cancer treatment can lead to high medical debt…

    Stage

    Not phased

    Ages

    18 and older

    Site

    PeaceHealth St. John Medical Center, Longview, Washington

    Locations

    3 in total

    Run by

    Fred Hutchinson Cancer Center

    See if you can join NCT06771739 on ClinicalTrials.gov

12. Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

    This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the earl…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    Anchorage Associates in Radiation Medicine, Anchorage, Alaska

    Locations

    745 in total

    Run by

    Alliance for Clinical Trials in Oncology

    See if you can join NCT05334069 on ClinicalTrials.gov

13. The Vanguard Study: Testing a New Way to Screen for Cancer

    The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand h…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Kaiser Permanente-Division of Research, Pleasanton, California

    Locations

    44 in total

    Run by

    National Cancer Institute (NCI)

    See if you can join NCT06995898 on ClinicalTrials.gov

14. Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

    This phase II trial tests the safety of positron emission tomography (PET) guided stereotactic body radiation therapy (SBRT) and how well it works to treat non-small cell lung cancer (NSCLC), melanoma, and renal cell carcinoma (RCC) that has up to 5 sites of progression (oligoprogression) compared …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    City of Hope Medical Center, Duarte, California

    Locations

    2 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT05830058 on ClinicalTrials.gov

15. Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

    This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. I…

    Stage

    Phase 3

    Ages

    Up to 39

    Site

    Children's Hospital of Alabama, Birmingham, Alabama

    Locations

    206 in total

    Run by

    Children's Oncology Group

    See if you can join NCT06513962 on ClinicalTrials.gov

16. Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting

    This clinical trial tests how well aromatherapy essential oils work to manage anxiety and nausea in cancer patients receiving infusions in the ambulatory setting. Current drugs that are given for nausea may cause constipation and fatigue. Therefore, there is interest in exploring complementary ther…

    Stage

    Not phased

    Ages

    18 and older

    Site

    City of Hope Medical Center, Duarte, California

    Locations

    2 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT07126301 on ClinicalTrials.gov

17. Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers

    The phase II trial evaluates the effectiveness of cryocompression therapy alone or in combination with cilostazol in preventing paclitaxel-induced peripheral neuropathy (numbness, pain or tingling in the feet and hands) for patients with gynecologic cancers. Peripheral neuropathy is a common side e…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Emory University Hospital Midtown, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT06492070 on ClinicalTrials.gov

18. Project: Every Child for Younger Patients With Cancer

    This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

    Stage

    Not phased

    Ages

    Up to 25

    Site

    Children's Hospital of Alabama, Birmingham, Alabama

    Locations

    279 in total

    Run by

    Children's Oncology Group

    See if you can join NCT02402244 on ClinicalTrials.gov

19. CREATE: Art for Children With Cancer

    This clinical trial is being done to develop and test how well creative arts interventions (drawing, painting, making sculptures) compared to watching videos can affect symptoms and impact the quality of life in children with cancer. Creative arts mind-body interventions (CrA) are one type of compl…

    Stage

    Not phased

    Ages

    8 to 13

    Site

    OHSU Knight Cancer Institute, Portland, Oregon

    Run by

    OHSU Knight Cancer Institute

    See if you can join NCT06342453 on ClinicalTrials.gov

20. Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

    This study performs standardized testing of tumor tissue samples to learn which genes are mutated (have changed) in order to provide personalized cancer therapy options to cancer patients at MD Anderson. This may help doctors use testing information on tumors to identify clinical trials that may be…

    Stage

    Not phased

    Ages

    Any age

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT01772771 on ClinicalTrials.gov

21. Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

    This study explores the potential value of a new blood test approach for early detection of cancer.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06304168 on ClinicalTrials.gov

22. Wearable Activity Tracking to Curb Hospitalizations

    This study is being done to collect patient generated health data to predict the risk of patients needing emergency department visits or hospitalization before, during. and after receiving radiation therapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06587100 on ClinicalTrials.gov

23. Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

    This phase III trial studies the side effects and how well stereotactic radiosurgery (SRS) works before or after surgery in patients with tumors that has spread to the brain or that can be removed by surgery. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high …

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mayo Clinic in Arizona, Scottsdale, Arizona

    Locations

    4 in total

    Run by

    Mayo Clinic

    See if you can join NCT03750227 on ClinicalTrials.gov

24. Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

    This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Arizona, Scottsdale, Arizona

    Locations

    4 in total

    Run by

    Mayo Clinic

    See if you can join NCT06353191 on ClinicalTrials.gov

25. Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

    This study investigates whether alteplase can help to improve pleural fluid drainage and dyspnea (breathlessness) in patients with non-draining malignant pleural effusion. Alteplase helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. Alteplase may help to…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Locations

    2 in total

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06184321 on ClinicalTrials.gov