Knee Osteoarthritis Clinical Trials

42 studies are recruiting for knee osteoarthritis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. The Effects of Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis

   The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. The main questions it aims to answer are: * What baseline patient characteristics predict respon…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of California Davis Health, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT06574191 on ClinicalTrials.gov

2. Focused Extracorporeal Shockwave Therapy for Knee Arthritis

   Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty. OA-related BMLs may regress or resolve within 30 months which could be…

   Stage

   Not phased

   Ages

   30 to 80

   Site

   New Jersey Regenerative Institute, Cedar Knolls, New Jersey

   Locations

   2 in total

   Run by

   Kessler Foundation

   See if you can join NCT05596591 on ClinicalTrials.gov

3. Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

   Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA). The neutral position is different than the human knee's natural position, so MA of…

   Stage

   Not phased

   Ages

   21 to 79

   Site

   Northwestern Medicine, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT06617871 on ClinicalTrials.gov

4. Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis

   The goal of this clinical trial is to learn if genicular artery embolization (GAE) can improve knee pain and decrease inflammation in adults with knee osteoarthritis. The main question it aims to answer is: - Does the GAE procedure improve knee pain and decrease inflammation? Researchers will compa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06940479 on ClinicalTrials.gov

5. General vs Spinal in Total Joint Arthroplasty (TJA)

   The purpose of this research is to compare post-operative outcomes from patients undergoing TJA. The study team wants to learn about outcomes like length of hospital stay, post-operative pain scores, post-operative nausea, deep and superficial surgical site infection, periprosthetic fracture (a bro…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06747494 on ClinicalTrials.gov

6. Return to Golf After Orthopaedic Surgery

   The GOLF study is a multicenter, prospective study with the goal to investigate golfers' return to the sport following hip, knee or shoulder arthroplasty. The prevalence of return to golf, by level of returning to golf will be assessed at 6 weeks, 3 months, 6 months, and 12 months postoperatively. …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hospital for Special Surgery, New York, New York

   Locations

   2 in total

   Run by

   Hospital for Special Surgery, New York

   See if you can join NCT05675618 on ClinicalTrials.gov

7. Investigating Patient Satisfaction With Smart Knee Implants

   The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee replacement surgery, as tracked through remote monitoring. A secondary goal is t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The University of Chicago Medical Center, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT06968143 on ClinicalTrials.gov

8. Knee Biofeedback Rehabilitation Through Game Therapy

   The goal of this study is to learn about the effect of video-game based rehabilitation exercise for patients with knee osteoarthritis. The main question the study aims to answer is: do patients who exercise with the game have better functional outcomes and engagement compared to patients who do con…

   Stage

   Not phased

   Ages

   30 to 75

   Site

   University of North Carolina Chapel Hill, Chapel Hill, North Carolina

   Run by

   Barron Associates, Inc.

   See if you can join NCT06090097 on ClinicalTrials.gov

9. Ischemic Preconditioning in Osteoarthritis and Back Pain

   We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

   Stage

   Not phased

   Ages

   50 and older

   Site

   Human and Sport Performance Lab, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT07003113 on ClinicalTrials.gov

10. Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

    Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-rel…

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06859164 on ClinicalTrials.gov

11. A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

    The objectives of this prospective observational cohort study are to evaluate the safety, reliability, reproducibility, and accuracy of the Canary canturioTM te post-TKA.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ozark Orthopaedics, Fayetteville, Arkansas

    Locations

    7 in total

    Run by

    Canary Medical

    See if you can join NCT06040827 on ClinicalTrials.gov

12. Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty

    Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives. Theoretically, achievement of normal knee motion using a medial pivot design in total knee replacements can be recreated in comparison …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Sinai Hospital of Baltimore, Baltimore, Maryland

    Run by

    LifeBridge Health

    See if you can join NCT04814082 on ClinicalTrials.gov

13. Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

    The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioecon…

    Stage

    Not phased

    Ages

    45 to 90

    Site

    The University of Texas at El Paso, El Paso, Texas

    Run by

    University of Texas, El Paso

    See if you can join NCT06105788 on ClinicalTrials.gov

14. Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis

    To evaluate pain relief from corticosteroid injection with and without anesthetic as well as with variable volume of anesthetic. Pain relief will be measured using the VAS pain score at the time of the injection as well as several time points following the injection to capture pain relief longevity…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Florida Orthopaedic Institute, Tampa, Florida

    Run by

    Foundation for Orthopaedic Research and Education

    See if you can join NCT05906433 on ClinicalTrials.gov

15. Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

    This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis. The aim is to demonstrate superior efficacy of platelet-rich plasma (PRP) as compared to hyaluronic acid (HA) in treating knee osteoa…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    NorthShore University HealthSystems, Skokie, Illinois

    Run by

    Endeavor Health

    See if you can join NCT03491761 on ClinicalTrials.gov

16. Effects of Gait Retraining on Lower Extremity Biomechanics

    The purpose of this proposed study is to investigate both the acute and chronic response of frontal plane knee moment after gait retraining and to assess the effects on the biomechanics of the contralateral side. Fifty-one patients diagnosed with tibiofemoral joint osteoarthritis (TFJ OA) will be r…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Sports Medicine, Assessment, Research & Testing (SMART) Laboratory, Manassas, Virginia

    Run by

    George Mason University

    See if you can join NCT03663790 on ClinicalTrials.gov

17. Gait Analysis of a Lateral-Pivot Design Total Knee Replacement

    Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis. With proper techniques and analysis differences between osteoarthritis patient groups can be distinguished. Previous research ha…

    Stage

    Not phased

    Ages

    50 and older

    Site

    MORE Foundation, Phoenix, Arizona

    Run by

    More Foundation

    See if you can join NCT04275362 on ClinicalTrials.gov