Knee Osteoarthritis Clinical Trials

42 studies are recruiting for knee osteoarthritis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Chicago, Illinois 9 Cleveland, Ohio 3

Studies now recruiting

  1. Remote Tai Chi for Knee Osteoarthritis

    The goal of this pragmatic randomized trial is to evaluate the effectiveness of remote Tai Chi to treat knee pain in adults with knee osteoarthritis. The main questions the trial aims to answer are: * Compared to routine care, will patients with Knee OA receiving remote Tai Chi exhibit greater impr…

    Stage
    Not phased
    Ages
    50 to 100
    Site
    Tufts Medical Center, Boston, Massachusetts
    Run by
    Tufts Medical Center

    See if you can join NCT06384898 on ClinicalTrials.gov

  2. Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

    To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale New Haven Health Old Saybrook Medical Center, Old Saybrook, Connecticut
    Run by
    Yale University

    See if you can join NCT07639060 on ClinicalTrials.gov

  3. Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

    The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or in…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Walter Reed National Military Medical Center, Bethesda, Maryland
    Run by
    Walter Reed National Military Medical Center

    See if you can join NCT07151417 on ClinicalTrials.gov

  4. Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain

    Knee osteoarthritis (OA) is the most prevalent form of arthritis, a significant cause of disability in the U.S. With an aging population and the rise in obesity rates, the prevalence of knee OA is expected to climb, significantly reducing quality of life (QOL) for those suffering from this debilita…

    Stage
    Not phased
    Ages
    40 to 75
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT05785884 on ClinicalTrials.gov

  5. Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation

    This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale New Haven Hospital Saint Raphael's Campus, New Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT06407427 on ClinicalTrials.gov

  6. Innovations in Genicular Outcomes Registry

    The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA. The OA pain therapies may include cryo nerve block, radiofrequency ablation (RFA), intra-articular (IA) cortic…

    Stage
    Not phased
    Ages
    Any age
    Site
    The MORE Foundation, Phoenix, Arizona
    Locations
    19 in total
    Run by
    Pacira Pharmaceuticals, Inc

    See if you can join NCT05495334 on ClinicalTrials.gov

  7. Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

    This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of exercises. The findings will enhance our understanding of the mechanisms underlying mind-body exercise and facilitate the development of new pain management approaches.

    Stage
    Phase 2
    Ages
    45 to 75
    Site
    Massachusetts General Hospital, Charlestown, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05839535 on ClinicalTrials.gov

  8. Genicular Artery Embolization for Knee Osteoarthritis

    Patients will be asked to take part in this research study because they have mild-to-moderate knee osteoarthritis (OA) and were referred clinically for a procedure called Genicular Artery Embolization (GAE). Osteoarthritis is the most common form of arthritis. It occurs when the protective cartilag…

    Stage
    Not phased
    Ages
    40 to 80
    Site
    Northwestern University, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT07537153 on ClinicalTrials.gov

  9. Persona Revision Knee System Outcomes

    The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Advanced Orthopaedic Specialists, Fayetteville, Arkansas
    Locations
    16 in total
    Run by
    Zimmer Biomet

    See if you can join NCT04821154 on ClinicalTrials.gov

  10. Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

    The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery

    Stage
    Phase 4
    Ages
    18 and older
    Site
    University of Miami Hospital, Miami, Florida
    Run by
    University of Miami

    See if you can join NCT06902285 on ClinicalTrials.gov

  11. BioPoly® Partial Resurfacing Knee Implant IDE

    The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients with knee pain and symptoms who are candidates for surgical intervention…

    Stage
    Not phased
    Ages
    30 to 65
    Site
    Dupont Hospital, Fort Wayne, Indiana
    Locations
    4 in total
    Run by
    BioPoly LLC

    See if you can join NCT06915363 on ClinicalTrials.gov

  12. A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

    Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability worldwide. Knee arthritis pain and disability are high…

    Stage
    EARLY_Phase 1
    Ages
    50 to 95
    Site
    UCLA Semel Institute - Neuropsychiatric Institute (NPI), Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT06906939 on ClinicalTrials.gov

  13. MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design

    The purpose of this investigational device exemption (IDE) study is to monitor the performance (safety and efficacy) of the Maxx Orthopedics, Freedom Total Knee® System, with a femoral component of similar design, manufactured from polyether-ether-ketone (PEEK).

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ascentis, Leawood, Kansas
    Locations
    2 in total
    Run by
    Maxx Orthopedics Inc

    See if you can join NCT06627673 on ClinicalTrials.gov

  14. Gait Rehabilitation to Treat FastOA

    The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.

    Stage
    Not phased
    Ages
    16 to 35
    Site
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Run by
    University of North Carolina, Chapel Hill

    See if you can join NCT05848622 on ClinicalTrials.gov

  15. Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

    Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves which have variable positions around the knee. Altern…

    Stage
    Not phased
    Ages
    35 to 99
    Site
    University of Rochester, Rochester, New York
    Locations
    2 in total
    Run by
    University of California, Davis

    See if you can join NCT04472702 on ClinicalTrials.gov

  16. Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

    This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline mental health and poor physical function, improves satisfaction at 1-year (…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Cleveland Clinic Foundation, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT06298721 on ClinicalTrials.gov

  17. FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

    This project aims to develop an [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. [18F] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity to…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UCSF Radiology China Basin, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07625150 on ClinicalTrials.gov

  18. Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

    Recruiting will be performed via checking the calendar for scheduled TKA procedures in the > 8 weeks by clinical staff in the UAMS orthopedic clinic. Clinic staff will look for basic inclusion/exclusion criteria in the EMR for those patients. Clinic staff will either contact directly or send contac…

    Stage
    Not phased
    Ages
    50 to 75
    Site
    University of Arkansas for Medical Sciences, Little Rock, Arkansas
    Run by
    University of Arkansas

    See if you can join NCT05823727 on ClinicalTrials.gov

  19. Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

    The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WO…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Chicago Duchossois Center for Advanced Medicine, Chicago, Illinois
    Run by
    University of Chicago

    See if you can join NCT06781463 on ClinicalTrials.gov

  20. ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

    The aim of this study is to conduct a comparative evaluation of the ROAM OA Single Upright Brace and the Ossur Unloader One Knee Brace in subjects with medial compartment osteoarthritis. The focus is on comparing the immediate and short-term biomechanical effects of these braces on knee adduction m…

    Stage
    Not phased
    Ages
    40 to 85
    Site
    Rush University Medical Center, Chicago, Illinois
    Run by
    Rush University Medical Center

    See if you can join NCT07224958 on ClinicalTrials.gov

  21. Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function QUERI 3.0

    Implementing Group Physical Therapy for Veterans with Knee Osteoarthritis (Group PT): Function QUERI 3.0 aims to compare two implementation approaches for implementing Group PT in 20 VA facilities using a type III effectiveness-implementation hybrid study framework and parallel cluster randomized t…

    Stage
    Not phased
    Ages
    Any age
    Site
    Durham VA Medical Center, Durham, NC, Durham, North Carolina
    Run by
    VA Office of Research and Development

    See if you can join NCT07215572 on ClinicalTrials.gov

  22. Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

    Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called "runner's knee". It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stair…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Kansas Medical Center, Kansas City, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT07472088 on ClinicalTrials.gov

  23. Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

    This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment gro…

    Stage
    Phase 4
    Ages
    41 and older
    Site
    Northwestern University, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT06245109 on ClinicalTrials.gov

  24. A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

    This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis. The purpose of the trial is to evaluate the efficacy, safety, and tolerability of a single int…

    Stage
    Phase 3
    Ages
    40 to 80
    Site
    Central Research Associates, LLC dba Flourish Research, Birmingham, Alabama
    Locations
    17 in total
    Run by
    Doron Therapeutics Inc.

    See if you can join NCT07219771 on ClinicalTrials.gov

  25. Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis

    This research will compare the effectiveness of a remotely delivered personalized exercise coaching plus an evidence-based sleep improvement intervention to remotely delivered personalized exercise coaching alone for knee osteoarthritis pain. The study team hypothesize that the combined interventio…

    Stage
    Not phased
    Ages
    50 and older
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT06580561 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.