Head and Neck Cancer Clinical Trials

96 studies are recruiting for head and neck cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 4

1. Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

   Radiation-induced xerostomia (dry mouth) is one of the most common and severe side effects for patients receiving radiation therapy for head and neck cancer. New approaches are needed to reduce this side effect and improve patients' quality of life after treatment. This is a Phase II, single-center…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT07278557 on ClinicalTrials.gov

2. Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

   This research study is studying the effect of different drugs as possible treatments for salivary and other head and neck cancers/ The name of the study intervention involved in this study is: -- implantable microdevice

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT05553782 on ClinicalTrials.gov

3. cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

   This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gast…

   Stage

   Not phased

   Ages

   40 and older

   Site

   City of Hope, Duarte, California

   Locations

   17 in total

   Run by

   Adela, Inc

   See if you can join NCT05366881 on ClinicalTrials.gov

4. Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

   The goal of this clinical trial is to assess the safety and tolerability of a virus replicon particle (VRP) encapsulated saRNA encoding IL-12 when injected into in head and neck cancer patients. The main questions being addressed are: The safety and tolerability of intratumoral (IT) injections of V…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Stanford University, Stanford, California

   Run by

   VLP Therapeutics

   See if you can join NCT06736379 on ClinicalTrials.gov

5. Sample Collection for Ongoing Research and Product Evaluation Study

   The SCORE study is a prospective, multi-site clinical trial designed to collect blood and tissue samples, along with relevant clinical data, from participants diagnosed with various solid tumors. The collected specimens and information will be used to evaluate the clinical performance of Natera's m…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Natera, Inc., Austin, Texas

   Run by

   Natera, Inc.

   See if you can join NCT07318051 on ClinicalTrials.gov

6. Intraoral Hypothermia Device for Preserving Taste During Radiation

   Radiation therapy to the head and neck region is known to cause taste dysfunction. Preliminary studies showed that cooling normal structures may lower damage caused by radiation. The purpose of this research study is to see if it is feasible to use an intraoral cooling device during radiation treat…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Henry Ford Health System, Detroit, Michigan

   Run by

   Henry Ford Health System

   See if you can join NCT06579248 on ClinicalTrials.gov

7. Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer

   Through this study, we hope to learn more about the mechanisms, which may contribute to development and progression of head and neck cancer. The long-term goal of this study will be to develop new strategies and drugs for the diagnosis and treatment of head and neck cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford University School of Medicine, Stanford, California

   Run by

   Stanford University

   See if you can join NCT00230308 on ClinicalTrials.gov

8. Phase II Panitumumab-IRDye800 in Head & Neck Cancer

   The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this drug.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT04511078 on ClinicalTrials.gov

9. Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

   The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual (TAU) to improve the initiation of guideline-adherent postoperative radiation therapy among patients with head and neck cancer. The main questions the trial…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   4 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT05793151 on ClinicalTrials.gov

10. Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

    Patients with human papillomavirus (HPV)-related oropharyngeal cancer generally have favorable outcomes and how well they do depends on the specific details about the patient and their cancer. How well they do isn't as related to the kinds of treatment they get. However, there are significant side …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Maryland Proton Treatment Center, Baltimore, Maryland

    Locations

    5 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06088381 on ClinicalTrials.gov

11. Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

    RATIONALE: Collecting and storing samples of tissue, saliva, and blood from patients with cancer and from healthy participants to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing tissue samples from patients with head and nec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee

    Locations

    4 in total

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT00898638 on ClinicalTrials.gov

12. A Motion Exergaming Approach for Symptom Management: HNC

    This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment. PAfitME stands for a personalized Physical Activity intervention with fitness graded Motion Exergames. PAfitME is deliver…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04632654 on ClinicalTrials.gov

13. Apixaban or Enoxaparin After Head and Neck Cancer Surgery

    The goal of this clinical trial is to learn if apixaban (a pill) is a safe and easier alternative to taking enoxaparin (a daily shot) to prevent blood clots after head and neck cancer surgery. It will also learn about side effects of both medicines. The main questions it aims to answer are: Can api…

    Stage

    Phase 4

    Ages

    18 to 89

    Site

    SUNY Upstate, Syracuse, New York

    Run by

    Kiranya Arnold

    See if you can join NCT07189897 on ClinicalTrials.gov

14. Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

    RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patie…

    Stage

    Not phased

    Ages

    21 to 90

    Site

    University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT00900419 on ClinicalTrials.gov

15. Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck

    The purpose of this study would like to learn if acupuncture-like electrical therapy can be used in patients with head and neck cancer who have had radiation treatment to treat dry mouth.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT04805528 on ClinicalTrials.gov

16. Supporting Treatment Resilience With Optimized Nutrition and Guided Exercise in Head and Neck Cancer Patients Undergoing Chemoradiation

    The purpose of this study to find out whether a structured lifestyle intervention-combining nutrition counseling, guided exercise, and wellness education-can help reduce treatment-related side effects and improve physical function, resilience, and quality of life in patients with head and neck canc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Renown Regional Medical Center, Reno, Nevada

    Locations

    2 in total

    Run by

    Renown Health

    See if you can join NCT07160296 on ClinicalTrials.gov

17. NLit and Outcomes in HNC Survivor-Caregiver Dyads

    The goal of this observational (cross-sectional) study is to better understand nutrition literacy in survivor-caregiver dyads and its impact on nutrition related outcomes and quality of life. We're interested in finding out how much they know about nutrition and how this might relate to their overa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT07021885 on ClinicalTrials.gov

18. RAPA-201 Therapy of Solid Tumors

    The therapy of solid tumors has been revolutionized by immune therapy, in particular, approaches that activate immune T cells in a polyclonal manner through blockade of checkpoint pathways such as PD-1 by administration of monoclonal antibodies. In this study, the investigators will evaluate the ad…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Hackensack University Medical Center, Hackensack, New Jersey

    Run by

    Rapa Therapeutics LLC

    See if you can join NCT05144698 on ClinicalTrials.gov

19. Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

    This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head \& neck patients treated with PBS. The…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Thompson Proton Center, Knoxville, Tennessee

    Run by

    Covenant Health Cancer Center

    See if you can join NCT06183268 on ClinicalTrials.gov

20. Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer

    This is a study to establish a safe and feasible dose for prophylactic use of a combination of gabapentin and ketamine in head and neck cancer patients undergoing chemoradiation.

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Vanderbilt-Ingram Cancer Center, Nashville, Tennessee

    Run by

    Natalie Lockney

    See if you can join NCT05156060 on ClinicalTrials.gov

21. Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial

    The goal of this randomized treatment study is to formally compare quality of life in patients with at least one pN0 hemi-neck after resection of a squamous cell carcinoma of the oral cavity treated with a primary radiation therapy versus a secondary targeted radiation therapy approach, to provide …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Miami Cancer Institute, Miami, Florida

    Locations

    8 in total

    Run by

    London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    See if you can join NCT03997643 on ClinicalTrials.gov