Head and Neck Cancer Clinical Trials

101 studies are recruiting for head and neck cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

   The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT06137274 on ClinicalTrials.gov

2. Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

   Radiation fibrosis syndrome (RFS) is a general side effect of radiation therapy (RT) which can adversely impact patients chronically over years typically triggered by an acute inflammatory state that evolves into chronic inflammation and tissue remodeling causing lymphedema, fibrosis, pain, atrophy…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06708754 on ClinicalTrials.gov

3. Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

   This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dana Farber Cancer Institute, Boston, Massachusetts

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT03875716 on ClinicalTrials.gov

4. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

   The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Allegheny Health Network, Pittsburgh, Pennsylvania

   Locations

   18 in total

   Run by

   UMC Utrecht

   See if you can join NCT04075305 on ClinicalTrials.gov

5. Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

   The purpose of this study is to evaluate the safety, tolerability and maximum tolerated dose of tislelizumab in combination with pamiparib plus chemoradiotherapy (chemotherapy and radiation) in individuals with recurrent head and neck cancer, which means that the person's cancer has come back after…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   The University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT05526924 on ClinicalTrials.gov

6. Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

   The purpose of this study is to assess the objective response rate following neoadjuvant therapy with volrustomig, paclitaxel, and carboplatin in previously untreated human papillomavirus (HPV)-negative locally advanced head and neck squamous cell carcinoma .

   Stage

   Phase 2

   Ages

   18 and older

   Site

   The University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT07065630 on ClinicalTrials.gov

7. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

   This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving chemotherapy.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT07447050 on ClinicalTrials.gov

8. Microbiome in Head and Neck Squamous Cell Carcinoma

   This study aims to determine whether dysbiosis actively contributes to HNSCC and if so, the underlying molecular mechanisms.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Colorado Cancer Center, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT05837221 on ClinicalTrials.gov

9. Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

   Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escala…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT04354064 on ClinicalTrials.gov

10. Improving Care for Rural Patients With Solid Tumors

    This study will assess if the CARES (Cancer Advocacy, Resources, Education and Support) intervention improves time to start of treatment after diagnosis and time to treatment completion for solid tumors (ex: lung, head, neck, thyroid, cervical, breast, bladder, colon, and rectal cancers) in rural p…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Colorado Hospital, Aurora, Colorado

    Locations

    14 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT04916990 on ClinicalTrials.gov

11. Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

    This research study is studying the effect of different drugs as possible treatments for salivary and other head and neck cancers/ The name of the study intervention involved in this study is: -- implantable microdevice

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05553782 on ClinicalTrials.gov

12. cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

    This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gast…

    Stage

    Not phased

    Ages

    40 and older

    Site

    City of Hope, Duarte, California

    Locations

    17 in total

    Run by

    Adela, Inc

    See if you can join NCT05366881 on ClinicalTrials.gov

13. Sample Collection for Ongoing Research and Product Evaluation Study

    The SCORE study is a prospective, multi-site clinical trial designed to collect blood and tissue samples, along with relevant clinical data, from participants diagnosed with various solid tumors. The collected specimens and information will be used to evaluate the clinical performance of Natera's m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Natera, Inc., Austin, Texas

    Run by

    Natera, Inc.

    See if you can join NCT07318051 on ClinicalTrials.gov

14. Intraoral Hypothermia Device for Preserving Taste During Radiation

    Radiation therapy to the head and neck region is known to cause taste dysfunction. Preliminary studies showed that cooling normal structures may lower damage caused by radiation. The purpose of this research study is to see if it is feasible to use an intraoral cooling device during radiation treat…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Henry Ford Health System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT06579248 on ClinicalTrials.gov

15. Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer

    Through this study, we hope to learn more about the mechanisms, which may contribute to development and progression of head and neck cancer. The long-term goal of this study will be to develop new strategies and drugs for the diagnosis and treatment of head and neck cancer.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT00230308 on ClinicalTrials.gov

16. Phase II Panitumumab-IRDye800 in Head & Neck Cancer

    The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this drug.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04511078 on ClinicalTrials.gov

17. Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

    The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual (TAU) to improve the initiation of guideline-adherent postoperative radiation therapy among patients with head and neck cancer. The main questions the trial…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University in St. Louis, St Louis, Missouri

    Locations

    4 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT05793151 on ClinicalTrials.gov

18. Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

    Patients with human papillomavirus (HPV)-related oropharyngeal cancer generally have favorable outcomes and how well they do depends on the specific details about the patient and their cancer. How well they do isn't as related to the kinds of treatment they get. However, there are significant side …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Maryland Proton Treatment Center, Baltimore, Maryland

    Locations

    5 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06088381 on ClinicalTrials.gov

19. Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

    RATIONALE: Collecting and storing samples of tissue, saliva, and blood from patients with cancer and from healthy participants to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing tissue samples from patients with head and nec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee

    Locations

    4 in total

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT00898638 on ClinicalTrials.gov

20. Apixaban or Enoxaparin After Head and Neck Cancer Surgery

    The goal of this clinical trial is to learn if apixaban (a pill) is a safe and easier alternative to taking enoxaparin (a daily shot) to prevent blood clots after head and neck cancer surgery. It will also learn about side effects of both medicines. The main questions it aims to answer are: Can api…

    Stage

    Phase 4

    Ages

    18 to 89

    Site

    SUNY Upstate, Syracuse, New York

    Run by

    Kiranya Arnold

    See if you can join NCT07189897 on ClinicalTrials.gov

21. Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck

    The purpose of this study would like to learn if acupuncture-like electrical therapy can be used in patients with head and neck cancer who have had radiation treatment to treat dry mouth.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT04805528 on ClinicalTrials.gov

22. Supporting Treatment Resilience With Optimized Nutrition and Guided Exercise in Head and Neck Cancer Patients Undergoing Chemoradiation

    The purpose of this study to find out whether a structured lifestyle intervention-combining nutrition counseling, guided exercise, and wellness education-can help reduce treatment-related side effects and improve physical function, resilience, and quality of life in patients with head and neck canc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Renown Regional Medical Center, Reno, Nevada

    Locations

    2 in total

    Run by

    Renown Health

    See if you can join NCT07160296 on ClinicalTrials.gov

23. NLit and Outcomes in HNC Survivor-Caregiver Dyads

    The goal of this observational (cross-sectional) study is to better understand nutrition literacy in survivor-caregiver dyads and its impact on nutrition related outcomes and quality of life. We're interested in finding out how much they know about nutrition and how this might relate to their overa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT07021885 on ClinicalTrials.gov

24. RAPA-201 Therapy of Solid Tumors

    The therapy of solid tumors has been revolutionized by immune therapy, in particular, approaches that activate immune T cells in a polyclonal manner through blockade of checkpoint pathways such as PD-1 by administration of monoclonal antibodies. In this study, the investigators will evaluate the ad…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Hackensack University Medical Center, Hackensack, New Jersey

    Run by

    Rapa Therapeutics LLC

    See if you can join NCT05144698 on ClinicalTrials.gov

25. Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

    This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head \& neck patients treated with PBS. The…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Thompson Proton Center, Knoxville, Tennessee

    Run by

    Covenant Health Cancer Center

    See if you can join NCT06183268 on ClinicalTrials.gov