Head and Neck Cancer Clinical Trials

101 studies are recruiting for head and neck cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

   This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels in cancer survivors (recently completing prior treatment regimens) or patients who have received whole bra…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT06580002 on ClinicalTrials.gov

2. Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS)

   This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, Davis, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT06103669 on ClinicalTrials.gov

3. Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations

   The PI and the research team developed the New York University (NYU) Electronic Patient Visit Assessment (ePVA) for head and neck cancer (HNC) as a patient-reported outcome measure (PRO) for the early detection of uncontrolled symptoms. The ePVA is digital patient-reported symptom monitoring system…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Kansas Cancer Center, Kansas City, Kansas

   Locations

   5 in total

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT06030011 on ClinicalTrials.gov

4. Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

   The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford University School of Medicine, Stanford, California

   Run by

   Stanford University

   See if you can join NCT00568490 on ClinicalTrials.gov

5. Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

   The purpose of the Phase I study is to see if it is safe to use X-ray photon radiation (XRT) and proton radiation (PT) before surgery in patients with recurrent head and neck squamous cell carcinoma (rHNSCC). The purpose of the Phase II study is to see if using XRT or PT before immunotherapy (pembr…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Cincinnati Medical Center, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT07213934 on ClinicalTrials.gov

6. Clonal Hematopoiesis Chemotherapy and Radiation Effects Study

   The goal of the Clonal Hematopoiesis Chemotherapy and Radiation Effects (CH CARE) Study is to understand how the presence or absence of clonal hematopoiesis (CH) influences outcomes in people receiving chemotherapy and radiation for solid cancers. The study will collect biospecimens and clinical in…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dana-Farber Cancer Institute, Boston, Massachusetts

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT07675967 on ClinicalTrials.gov

7. Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

   The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat their tumor, and if this will help reduce neurocognitive (thinking and learning) impairments in thes…

   Stage

   Not phased

   Ages

   1 to 26

   Site

   Sibley Memorial Hospital, Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

   See if you can join NCT05658731 on ClinicalTrials.gov

8. Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

   This study will collect tumor specimens with correlated clinical and demographic data from patients who are undergoing a biopsy or similar procedure to obtain tumor tissue as a normal course of their medical management or diagnostic work-up for suspected or confirmed cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mercy Hospital - FTS, Fort Smith, Arkansas

   Locations

   8 in total

   Run by

   Elephas

   See if you can join NCT07327489 on ClinicalTrials.gov

9. Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

   This research study is evaluating effectiveness and safety of a combination of immunotherapy drug, pembrolizumab, with chemotherapy, as a possible treatment before and after surgery for squamous cell carcinoma of the head and neck (HNSCC). The combination of pembrolizumab and chemotherapy will be g…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Dana-Farber Cancer Institute, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT05726370 on ClinicalTrials.gov

10. Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

    The U.S. Food and Drug Administration approved photobiomodulation therapy (PBMT) as a treatment for breast cancer-related arm lymphedema (BCRL) in 2006. The investigators conducted two pilot clinical trials. Results demonstrated the feasibility, acceptability, and preliminary efficacy of PBMT for t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06837480 on ClinicalTrials.gov

11. Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

    The purpose of this study is to assess the safety and effectiveness of a drug called Pedmark® sodium thiosulfate (STS) in reducing hearing impairment with standard of care cisplatin therapy. The safety and effectiveness of STS in reducing hearing loss has been well established in children and is ap…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Arizona Cancer Center, Tucson, Arizona

    Run by

    University of Arizona

    See if you can join NCT07407582 on ClinicalTrials.gov

12. MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

    This is a multipart, open-label, multi-center dose escalation, dose expansion phase I clinical trial designed to evaluate the safety, tolerability, maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), and preliminary efficacy of MEM-288 in patients with advanced solid tumors. Eligible sub…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Moffitt Cancer Center, Tampa, Florida

    Locations

    2 in total

    Run by

    Memgen, Inc.

    See if you can join NCT05076760 on ClinicalTrials.gov

13. The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

    In this randomized behavioral intervention, head and neck cancer (HNC) survivors and their caregivers (N=176 HNC survivor-caregiver dyads) will be randomized to either Survivorship Needs Assessment Planning (SNAP) or Usual Care (UC) groups to examine the effects of SNAP on outcomes. SNAP includes t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05811936 on ClinicalTrials.gov

14. A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy

    The researchers are doing this study to collect more information about if, and how, neurocognitive function may be affected in people being treated with radiation therapy for head and neck cancer. Part of this study is to see if patients diagnosed with head and neck cancer who are undergoing radiat…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT05207098 on ClinicalTrials.gov

15. Skin Color Matching in Head and Neck Reconstructive Surgery

    This study will examine whether cutaneous reconstruction with RECELL® atop de-epithelialized tissue provides better skin color matching than standard grafting methods. The goal is to compare color match, healing, and patient satisfaction across three reconstruction techniques. Color matching will b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shoreline Surgery Center, Guilford, Connecticut

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT07431099 on ClinicalTrials.gov

16. Brodalumab in the Treatment of Immune-Related Adverse Events

    The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Brian Henick, MD

    See if you can join NCT06673329 on ClinicalTrials.gov

17. A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

    By doing this study, the research team would like to learn if using a blood test that measures the amount of tumor DNA in blood can help guide how to use chemotherapy combined with immunotherapy for individuals with head and neck cancer. Using this blood test, the research team hopes to learn if in…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Chicago Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT05420948 on ClinicalTrials.gov

18. ATATcH Alternating Treatment Plans for Advanced Cancer

    The purpose of the research is to evaluate a new schedule of alternating cycles of induction chemoimmunotherapy (chemotherapy plus pembrolizumab) and immunotherapy (pembrolizumab) alone for the initial treatment of patients with advanced lung or head and neck cancers.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Trinitas Hospital and Comprehensive Cancer Center, Elizabeth, New Jersey

    Locations

    11 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT05358548 on ClinicalTrials.gov

19. PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivors

    The purpose of this study is to assess the awareness of eligibility of lung cancer screening in Hispanic/LatinX Head and Neck Cancer (HNC) survivors using a survey questionnaire; and to understand the barriers to screening using qualitative interviews.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06124508 on ClinicalTrials.gov

20. Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study

    Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), a problem with closure between the soft palate and throat that can cause nasal-sounding speech, food or liquid leaking into the nose, difficulty swallowing, and reduced quality of life. This study aims to better understan…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    Vanessa Torrecillas

    See if you can join NCT07264036 on ClinicalTrials.gov

21. Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

    The NeoScorch HN study is a single institution multisite phase II trial including 3 cohorts of 25 patients each for patients with newly diagnosed locoregionally advanced, histologically confirmed, head and neck cancer eligible for curative-intent treatment, who will receive neo-adjuvant chemoimmuno…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins Hospital East Baltimore, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT07209189 on ClinicalTrials.gov

22. Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

    To determine the risk of solitary elective volume recurrence following involved nodal radiotherapy (INRT) versus elective nodal irradiation (ENI)

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06477692 on ClinicalTrials.gov

23. New MRI Biomarkers in Head and Neck Cancers

    Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt. This makes specific organs, blood vessels, or tumors easier to see. Diffusion MRI lets us measure the motion of water in the tumor. The …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT03483337 on ClinicalTrials.gov

24. A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

    This is a non-randomized, open-label, single-center, safety and imaging feasibility study of Pegsitacianine, an intraoperative fluorescence imaging agent.

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05576974 on ClinicalTrials.gov

25. Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

    The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with traditional pho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The New York Proton Center, New York, New York

    Run by

    The New York Proton Center

    See if you can join NCT05313191 on ClinicalTrials.gov