Autism Spectrum Disorder Clinical Trials

104 studies are recruiting for autism spectrum disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Speech Treatment for Minimally Verbal Children With ASD and CAS

   Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with…

   Stage

   Not phased

   Ages

   5 to 18

   Site

   MGH Institute of Health Professions, Boston, Massachusetts

   Run by

   MGH Institute of Health Professions

   See if you can join NCT05066178 on ClinicalTrials.gov

2. Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders

   Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder caused by a mutation on the X chromosome. Scientists have investigated FXS extensively in both humans and animals. Thus far, phenotypic rescue in animal models has not resulted in treatment breakthroughs in humans, though some import…

   Stage

   Not phased

   Ages

   5 to 10

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT06227780 on ClinicalTrials.gov

3. Investigating a Marijuana-based Compound as a Treatment for Anxiety in Autistic Adults

   The goal of this clinical trial is to learn if drug ABC works to treat severe asthma in adults. It will also learn about the safety of drug ABC. The main questions it aims to answer are: Will a marijuana-based drug help anxiety in autistic adults? Anxiety can make socializing and working more diffi…

   Stage

   Phase 2

   Ages

   18 to 45

   Site

   Southwest Autism Research and Resource Center, Phoenix, Arizona

   Run by

   Southwest Autism Research & Resource Center

   See if you can join NCT06526208 on ClinicalTrials.gov

4. Telehealth Mindfulness-based Intervention for Adolescents With Autism Spectrum Disorder and Their Caregivers

   The goal of this clinical trial is to learn whether a mindfulness-based intervention can reduce depression and anxiety in autistic adolescents. The main question this trial aims to answer is: Do adolescents who complete MINDful TIME show reductions in depression and anxiety compared to an active co…

   Stage

   Not phased

   Ages

   13 to 18

   Site

   Southwest Autism Research & Resource Center, Phoenix, Arizona

   Run by

   Nicole Matthews, Ph.D.

   See if you can join NCT07501286 on ClinicalTrials.gov

5. Trial of Diphenhydramine for Sleep in Children With Autism

   The purpose of this study is to examine the effect of diphenhydramine on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic agent with strong hypnotic properties. To accomplish this, the investigators will use a randomized double-blind pl…

   Stage

   Phase 2

   Ages

   8 to 17

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT05501678 on ClinicalTrials.gov

6. Trial of Zolpidem for Sleep in Children With Autism

   The purpose of this study is to examine the effect of zolpidem on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Zolpidem is a nonbenzodiazepine GABAa receptor agonist drug that acts as a hypnotic. To accomplish this, the investigators will use a randomized double-blind plac…

   Stage

   Phase 2

   Ages

   8 to 17

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT05540574 on ClinicalTrials.gov

7. Trial of Suvorexant for Sleep in Children With Autism

   The purpose of this study is to examine the effect of suvorexant on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Suvorexant is a selective, dual orexin receptor antagonist (DORA) used for the treatment of sleep onset difficulties and/or sleep maintenance. To accomplish thi…

   Stage

   Phase 2

   Ages

   13 to 17

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT05546554 on ClinicalTrials.gov

8. Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

   The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to an…

   Stage

   Not phased

   Ages

   18 to 35

   Site

   Olin Neuropsychiatry Research Center (ONRC), Hartford, Connecticut

   Run by

   Yale University

   See if you can join NCT06214065 on ClinicalTrials.gov

9. Motor-voice Assessment in Infants (MAMI)

   The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are: Identify voice factors among infants with newborn-detectable risk. Identify associa…

   Stage

   Not phased

   Ages

   Up to 0

   Site

   The Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06807203 on ClinicalTrials.gov

10. Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders

    This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program. The program is designed for children with neurodevelopmental disorders, including but not limited to cerebral palsy, autism spec…

    Stage

    Not phased

    Ages

    4 to 12

    Site

    Ability and Beyond, The Woodlands, Texas

    Run by

    Healing Hope International

    See if you can join NCT07493096 on ClinicalTrials.gov

11. Cerebellar Stimulation and Cognitive Control

    The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Krystal Parker, PhD

    See if you can join NCT03217110 on ClinicalTrials.gov

12. Speech-in-noise Perception in Autism and Fragile X

    The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main quest…

    Stage

    Not phased

    Ages

    15 to 35

    Site

    Cincinnati Children'S Hospital, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT06088589 on ClinicalTrials.gov

13. STRW-T Intervention for Autistic Adolescents in 11th and 12th Grade

    The current study seeks to compare outcomes of a telehealth intervention targeting daily living skills (Surviving and Thriving in the Real World - Telehealth, or STRW-T) intervention to a control group telehealth intervention targeting social skills (Program for the Education and Enrichment of Rela…

    Stage

    Not phased

    Ages

    15 to 21

    Site

    University of North Carolina - Chapel Hill, Carrboro, North Carolina

    Locations

    2 in total

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT06552286 on ClinicalTrials.gov

14. Improving Academic and Social Functioning in Middle-Schoolers With Autism

    The goal of this study is to test how well two group interventions work for middle-school children with Autism Spectrum Disorder (ASD). One of the interventions focuses on teaching parents and adolescent skills to help improve their social functioning and the other focuses on teaching parents and a…

    Stage

    Not phased

    Ages

    10 to 15

    Site

    Cincinnati Children's Hospital, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT06705907 on ClinicalTrials.gov

15. Randomized Clinical Trial of TUNE In 3.0: A Social/Emotional Program for Adults With Autism Spectrum Disorder

    The purpose of this study is to test a novel, cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder. The treatment, named TUNE In (Training to Understand and Navigate Emotions and Interactions), includes components to address the many behavior…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brodkin Lab: Perelman School of Medicine, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06859918 on ClinicalTrials.gov

16. SenseToKnow Autism Screening Device Validation Study

    This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow device for the detection of autism spectrum disorder in children 16-36 months of age.

    Stage

    Not phased

    Ages

    1 to 3

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05874466 on ClinicalTrials.gov

17. The TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine

    The investigators are conducting a 10-week brain imaging and medication study. They are doing the research to study the response of Attention-Deficit/ Hyperactivity Disorder (ADHD) in youth with Autism Spectrum Disorder (ASD) on extended-release formulation of mixed amphetamine salts (MAS) (also kn…

    Stage

    Phase 4

    Ages

    8 to 18

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Gagan Joshi

    See if you can join NCT06853665 on ClinicalTrials.gov

18. Oxytocin Effects on Bone in Children With Autism Spectrum Disorder

    This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin on bone health in children with autism spectrum disorder, ages 6-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (30 IU, 2 times daily) for 12 months in the double-…

    Stage

    Phase 2

    Ages

    6 to 18

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Elizabeth Austen Lawson

    See if you can join NCT05754073 on ClinicalTrials.gov

19. Parent-Mediated Intervention Targeting Insistence on Sameness for Autistic Children

    This study will examine the potential effectiveness of a virtually delivered parent-mediated intervention for insistence on sameness behaviors in autism and investigate 1) whether caregivers can learn to deliver the adapted Supportive Parenting for Anxious Childhood emotions (SPACE) intervention fo…

    Stage

    Not phased

    Ages

    6 to 11

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06472115 on ClinicalTrials.gov

20. Effect of an 8-Week Pickleball Program for Adults With Autism: A Feasibility Trial With a Delayed-Control Design

    The goal of this clinical trial is to learn if an 8-week, community-based pickleball program can improve sensory-motor function and reduce the severity of core autism symptoms in adults ages 18-45 with autism spectrum disorder (ASD) who can participate independently without a caregiver. The main qu…

    Stage

    EARLY_Phase 1

    Ages

    18 to 45

    Site

    Penn State Harrisburg, Middletown, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT07432776 on ClinicalTrials.gov

21. Physical Activity and Community EmPOWERment Project

    Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease (AD)/age-related dementias (ARD). Participants: Participants include 120 adults with…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of North Carolina, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06740162 on ClinicalTrials.gov

22. Transcranial Direct Current Stimulation in Children With Autism

    Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who show an absence or a plateau in various skills. Deficits in executive fu…

    Stage

    Not phased

    Ages

    5 to 12

    Site

    New York State Institute for Basic Research, Staten Island, New York

    Run by

    New York State Institute for Basic Research

    See if you can join NCT07092280 on ClinicalTrials.gov

23. Transcranial Magnetic Stimulation (TMS) Study for Adults With Autism Spectrum Disorder (ASD)

    This is a randomized interventional study designed to evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in adults with autism spectrum disorder (ASD).

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Yale University Child Study Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04936009 on ClinicalTrials.gov

24. Neural Basis of Social Cognition Deficits

    Difficulties in reciprocal social interaction are hallmark features of several neuropsychiatric disorders, most notably autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD). While recent studies have demonstrated substantial overlap in genetic etiology between ASD and SSD, littl…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Loma Linda U, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT05185128 on ClinicalTrials.gov

25. Sleep and Central Auditory Processing Disorder in Autism Spectrum Disorder

    The proposed study aims to understand poor sleep as a possible cause to CAPD in children and adolescents with ASD (ASD+) compared to ASD youth without CAPD (ASD-), using both caregiver-report and objective clinician administered measures. Additionally, the study will aim to understand the complex r…

    Stage

    Not phased

    Ages

    6 to 17

    Site

    Loma Linda University Health, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT06059352 on ClinicalTrials.gov