Atrial Fibrillation Clinical Trials

64 studies are recruiting for atrial fibrillation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

   * The trial will compare two anticoagulants ("blood thinners") that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto). They a…

   Stage

   Phase 4

   Ages

   65 and older

   Site

   Miami VA Healthcare System, Miami, FL, Miami, Florida

   Locations

   5 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06953726 on ClinicalTrials.gov

2. Left Atrial Appendage Occlusion Registry (LAAO Registry)

   The Left Atrial Appendage Occlusion Registry (LAAO Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous and epicardial based left atrial appendage occlusion procedures to reduce the risk of stroke. Patient-level data will be sub…

   Stage

   Not phased

   Ages

   18 and older

   Site

   American College of Cardiology/National Cardiovascular Data Registry (NCDR), Washington D.C., District of Columbia

   Run by

   American College of Cardiology

   See if you can join NCT02699957 on ClinicalTrials.gov

3. Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

   The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).

   Stage

   Not phased

   Ages

   18 to 75

   Site

   East Jefferson General Hospital, New Orleans, Louisiana

   Locations

   3 in total

   Run by

   Tulane University

   See if you can join NCT04814420 on ClinicalTrials.gov

4. Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

   The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize t…

   Stage

   Not phased

   Ages

   40 to 120

   Site

   Lakeview Hospital, Covington, Louisiana

   Locations

   3 in total

   Run by

   Tulane University

   See if you can join NCT05014802 on ClinicalTrials.gov

5. Single Chamber Atrial Leadless Pacing for Isolated Sinus Node Dysfunction

   The study aims to evaluate the following: 1) the incidence of new onset atrial fibrillation in patients with an atrial leadless pacemaker, 2) the need for upgrade from a standalone atrial leadless pacemaker to a dual chamber leadless pacemaker system, and 3) to compare the battery longevity of the …

   Stage

   Not phased

   Ages

   18 and older

   Site

   South Shore University Hospital, Bay Shore, New York

   Locations

   6 in total

   Run by

   Northwell Health

   See if you can join NCT07638995 on ClinicalTrials.gov

6. Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer

   This phase II trial studies how well amiodarone works in the prevention of atrial fibrillation (AF) after a minimally invasive esophagectomy (MIE) in patients with esophageal cancer. Atrial fibrillation (AF) is an irregular heart rhythm, usually associated with a rapid rate, that is caused by abnor…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   OHSU Knight Cancer Institute, Portland, Oregon

   Run by

   OHSU Knight Cancer Institute

   See if you can join NCT06067438 on ClinicalTrials.gov

7. Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

   To evaluate the progression of atrial myopathy through wearable devices and cardiac imaging.

   Stage

   Not phased

   Ages

   18 to 79

   Site

   Tulane University School of Medicine, New Orleans, Louisiana

   Run by

   Tulane University School of Medicine

   See if you can join NCT04703166 on ClinicalTrials.gov

8. Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

   Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in b…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   University of Alabama Hospital, Birmingham, Alabama

   Locations

   187 in total

   Run by

   Yale University

   See if you can join NCT03907046 on ClinicalTrials.gov

9. Development of CIRC Technologies

   Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cardiovascular Innovation Research Center, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT05654272 on ClinicalTrials.gov

10. Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

    The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06575881 on ClinicalTrials.gov

11. Mobile Health Technology-Enabled AFib Management

    The overall objective of this proposal is to evaluate the effect on quality of life of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib management options, starting and adhering to evidence-based therapies…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06500988 on ClinicalTrials.gov

12. 320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

    This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, to measure left ventricular extracellular volume (ECV) as an indicator of fibrosis. The study will …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06308094 on ClinicalTrials.gov

13. Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)

    The study will investigate the effect of Dapagliflozin on atrial fibrillation (AF) burden. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm monitoring at baseline and at 3 months, quality of life (QOL) and validated e…

    Stage

    Phase 3

    Ages

    18 to 85

    Site

    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT05174052 on ClinicalTrials.gov

14. The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study

    The aim of the Correlation Of CoAGulation-Atrial Fibrillation (COAG-AF) study is to prove that an increase in pro-thrombotic biomarkers in AF is associated with an increase in AF burden. Secondary objectives of the study are the following: * To investigate the impact of catheter ablation on serum p…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    East Jefferson General Hospital, New Orleans, Louisiana

    Locations

    3 in total

    Run by

    Tulane University

    See if you can join NCT04947657 on ClinicalTrials.gov

15. Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

    The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac arterial bypass grafting (CABG) or valve surgery.

    Stage

    EARLY_Phase 1

    Ages

    20 to 85

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06063538 on ClinicalTrials.gov

16. Positron Emission Tomography (PET) Imaging of Thrombosis

    The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invas…

    Stage

    Phase 1

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT03830320 on ClinicalTrials.gov

17. The Dynamics of Human Atrial Fibrillation

    Atrial fibrillation (AF) is an enormous public health problem in the United States, affecting 2-5 million Americans and causing rapid heart beats, stroke, heart failure or death. In this project, the applicant will develop a novel framework to better understand human AF that builds on agreement bet…

    Stage

    Not phased

    Ages

    22 to 80

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05366361 on ClinicalTrials.gov

18. Ondansetron for the Management of Atrial Fibrillation

    "Afib" is a common irregular heartbeat. Afib can cause stroke, blood clots, dementia and death. Medicines used to treat Afib often do not work well and can cause serious side effects. Clinicians need medicines that work better for Afib. Medicines for Afib work by blocking a current in the heart cal…

    Stage

    Phase 4

    Ages

    18 to 100

    Site

    Indiana Clinical Research Center, Indianapolis, Indiana

    Locations

    3 in total

    Run by

    Indiana University

    See if you can join NCT05844501 on ClinicalTrials.gov

19. Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation

    VIBRANT-AF seeks to: * Identify clinically relevant predictors of effectiveness and complications of AF ablation procedures in a prospective, US-based, multi-center, real-world longitudinal study * Assess changes in modifiable lifestyle-related exposures influence the effectiveness of AF ablation *…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05504356 on ClinicalTrials.gov

20. TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

    This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom seve…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06802081 on ClinicalTrials.gov

21. Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

    Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient atrial fibrillation occurring transiently with stress and additional stroke risk factors.

    Stage

    Phase 4

    Ages

    55 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Locations

    105 in total

    Run by

    Population Health Research Institute

    See if you can join NCT03968393 on ClinicalTrials.gov

22. Renal Denervation + PVI vs PVI Alone for Persistent AF

    Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN). The recently completed randomized trial, ERADICATE-AF, convincingly demonstrat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Short Hills, New Jersey

    Run by

    University of Rochester

    See if you can join NCT05116384 on ClinicalTrials.gov

23. Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation

    Observational, multi-center, clinical device registry for US patients with a primary goal to observe the clinical outcomes in patients who are mapped with Volta Medical's VX1 or AF-Xplorer systems during AF ablation procedures.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Endeavor Health, Evanston, Illinois

    Locations

    4 in total

    Run by

    Volta Medical

    See if you can join NCT06056271 on ClinicalTrials.gov

24. COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation

    This is a cohort study to evaluate algorithms for mapping atrial fibrillation by mapping atrial structure and mapping electrical activity to detect physiologically important areas. A key innovation of the observation study is to assess tracking of physiological activity in AF, in relation to tissue…

    Stage

    Not phased

    Ages

    21 to 90

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT02997254 on ClinicalTrials.gov

25. Machine Learning in Atrial Fibrillation

    Atrial fibrillation is a serious public health issue that affects over 5 million Americans (Miyazaka, Circulation 2006) in whom it may cause skipped beats, dizziness, stroke and even death. Therapy for AF is currently suboptimal, in part because AF represents several disease states of which few hav…

    Stage

    Not phased

    Ages

    22 to 80

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05371405 on ClinicalTrials.gov