Atrial Fibrillation Clinical Trials

65 studies are recruiting for atrial fibrillation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

   REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in parti…

   Stage

   Phase 3

   Ages

   22 to 85

   Site

   Banner University, Phoenix, Arizona

   Locations

   93 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05836987 on ClinicalTrials.gov

2. A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

   The purpose of this study is to assess how safe VARIPULSE pulsed field ablation (PFA) catheter is and how well it works compared to food and drug administration (FDA) approved FARAWAVE PFA catheter in participants with symptomatic persistent atrial fibrillation (PsAF; continuous irregular, rapid he…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Arrhythmia Research Group, Jonesboro, Arkansas

   Locations

   20 in total

   Run by

   Biosense Webster, Inc.

   See if you can join NCT07523750 on ClinicalTrials.gov

3. A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation

   The purpose of this study is to assess how safe VARIPULSE catheter system is for treatment of a heart rhythm disease called persistent atrial fibrillation (PsAF) in participants who are having a catheter ablation procedure (treat heart rhythm disease). This includes isolation of pulmonary vein and …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Grandview Medical Center, Birmingham, Alabama

   Locations

   13 in total

   Run by

   Biosense Webster, Inc.

   See if you can join NCT07527299 on ClinicalTrials.gov

4. PULSED AF Post-Approval Study

   PULSED AF PAS is a prospective, global, multi-center, non-randomized, observational trial. Subjects will be treated with the PulseSelect™ PFA System and followed through 36 months.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Piedmont Heart Institute, Atlanta, Georgia

   Locations

   23 in total

   Run by

   Medtronic Cardiac Ablation Solutions

   See if you can join NCT06578104 on ClinicalTrials.gov

5. A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

   A randomized, placebo-controlled, participant-and investigator-blinded study to evaluate the efficacy in reducing atrial fibrillation burden as well as the safety, tolerability and pharmacokinetics of PKN605 in participants with atrial fibrillation

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cardiology Associates of North MS, Tupelo, Mississippi

   Locations

   40 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT07217067 on ClinicalTrials.gov

6. Globe Registry: Globe® Pulsed Field System Registry Study for Treating Patients With Symptomatic Atrial Fibrillation

   This post-market registry is designed to collect real world data on the use of the Globe PF System for the treatment of atrial fibrillation (AF).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arrhythmia Research Group, Jonesboro, Arkansas

   Locations

   2 in total

   Run by

   Kardium Inc.

   See if you can join NCT07651852 on ClinicalTrials.gov

7. Pericardiotomy in Cardiac Surgery

   PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Louisville, Louisville, Kentucky

   Locations

   19 in total

   Run by

   Population Health Research Institute

   See if you can join NCT06486636 on ClinicalTrials.gov

8. Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA

   The study is a prospective, exploratory observational study with the ECGenius® System and the PFAnalyzer software module in PFA cases using the FaraPulse PFA system. The cohort will be patients with paroxysmal or persistent atrial fibrillation (AF) who undergo PVI using this system.

   Stage

   Not phased

   Ages

   21 and older

   Site

   The Valley Hospital, Paramus, New Jersey

   Locations

   2 in total

   Run by

   CathVision ApS

   See if you can join NCT07275151 on ClinicalTrials.gov

9. Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

   To evaluate the progression of atrial myopathy through wearable devices and cardiac imaging.

   Stage

   Not phased

   Ages

   18 to 79

   Site

   Tulane University School of Medicine, New Orleans, Louisiana

   Run by

   Tulane University School of Medicine

   See if you can join NCT04703166 on ClinicalTrials.gov

10. A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

    The main goal of this study is to find out how well BAY 3670549 works, how safe it is, how well people can tolerate it, and how the body handles the medicine. The study will compare BAY 3670549 to a placebo (a dummy treatment with no active medicine) in people with AF who need a treatment called el…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Henry Ford Hospital - Cardiology, Detroit, Michigan

    Locations

    30 in total

    Run by

    Bayer

    See if you can join NCT07625215 on ClinicalTrials.gov

11. Renal Denervation + PVI vs PVI Alone for Persistent AF

    Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN). The recently completed randomized trial, ERADICATE-AF, convincingly demonstrat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Short Hills, New Jersey

    Run by

    University of Rochester

    See if you can join NCT05116384 on ClinicalTrials.gov

12. ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

    This is a multi-national, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of etripamil NS in patients with atrial fibrillation (AF). This study includes Screening Visit, Randomization Visit, a Treatment Period with scheduled Follow-up Visits (Monthly Follow-…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Interventional Cardiology Medical Group (West Hills, CA), West Hills, California

    Locations

    15 in total

    Run by

    Milestone Pharmaceuticals Inc.

    See if you can join NCT06716021 on ClinicalTrials.gov

13. Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation

    VIBRANT-AF seeks to: * Identify clinically relevant predictors of effectiveness and complications of AF ablation procedures in a prospective, US-based, multi-center, real-world longitudinal study * Assess changes in modifiable lifestyle-related exposures influence the effectiveness of AF ablation *…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05504356 on ClinicalTrials.gov

14. A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

    The purpose of this study is to evaluate the long-term safety and effectiveness of the FDA approved VARIPULSE catheter system for pulmonary vein isolation (PVI) in the treatment of participants with symptomatic paroxysmal atrial fibrillation (PAF).

    Stage

    Not phased

    Ages

    22 and older

    Site

    Phoenix Cardiovascular Research Group, Phoenix, Arizona

    Locations

    23 in total

    Run by

    Biosense Webster, Inc.

    See if you can join NCT07227532 on ClinicalTrials.gov

15. Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

    The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Advocate Christ Medical Center Emergency Department (ACMC ED), Oak Lawn, Illinois

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06376916 on ClinicalTrials.gov

16. Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

    * The trial will compare two anticoagulants ("blood thinners") that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto). They a…

    Stage

    Phase 4

    Ages

    22 and older

    Site

    Miami VA Healthcare System, Miami, FL, Miami, Florida

    Locations

    9 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06953726 on ClinicalTrials.gov

17. The Fourth Left Atrial Appendage Occlusion Study

    LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arrhythmia Research Group, Jonesboro, Arkansas

    Locations

    150 in total

    Run by

    Hamilton Health Sciences Corporation

    See if you can join NCT05963698 on ClinicalTrials.gov

18. Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF

    Earlier studies have shown a dose-dependent relationship between alcohol intake and incident atrial fibrillation (AF) as well as a causal link with several risk factors for AF such as hypertension, obesity and sleep apnea. However, the effect of drinking (alcohol) on post-ablation outcome such as a…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas

    Run by

    Texas Cardiac Arrhythmia Research Foundation

    See if you can join NCT05510167 on ClinicalTrials.gov

19. High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation

    Patients undergoing FIRM guided ablation of atrial fibrillation will undergo high resolution MRI imaging to determine correlation of underlying anatomic fibrotic regions with FIRM targeted sites for ablation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT03444337 on ClinicalTrials.gov

20. CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation

    The primary objective of this Pivotal study is to demonstrate the safety and effectiveness of the Pulse Biosciences nsPFA™ Cardiac Surgery System in treating atrial fibrillation during concomitant cardiac surgical procedures.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Adventist Heart Institute: Adventist Health St. Helena, St. Helena, California

    Locations

    3 in total

    Run by

    Pulse Biosciences, Inc.

    See if you can join NCT06959121 on ClinicalTrials.gov

21. Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

    This is a prospective multicenter clinical study comparing the efficacy of the Apple Watch AFib History tool to the iRhythm Zio Patch monitoring device in quantifying atrial fibrillation (AF) burden after surgical ablation. Patients with AF and mitral valve (MV) disease who undergo a Cox-Maze IV pr…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Washington University School of Medicine in St. Louis, St Louis, Missouri

    Locations

    2 in total

    Run by

    The Cleveland Clinic

    See if you can join NCT07122947 on ClinicalTrials.gov

22. Evaluation of 4D Intracardiac Echocardiography (ICE) During Structural Heart and Electrophysiology Procedures

    The purpose of this study is to evaluate the imaging performance and procedural safety of a prototype 4D ICE catheter during real-time intracardiac imaging and to optimize device imaging parameters, compared with current standard imaging modalities. TEE is the current standard of care and will serv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinical Foundation, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07806890 on ClinicalTrials.gov

23. Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

    Atrial fibrillation (AF) affects 1 in 4 individuals during their lifetime and continues to increase in frequency and impact. Exercise intervention has established benefits to improve AF symptoms and burden in clinical studies. However, lack of access to exercise programs has limited therapeutic ado…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06938412 on ClinicalTrials.gov

24. NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

    The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascular disease in patients. It will also examine the safety and effectiveness of using this AI-based to…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06511505 on ClinicalTrials.gov

25. Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation

    Patients with atrial fibrillation (AF) who have had a prior stroke are at very high risk of recurrent ischemic stroke. About 40% of these strokes are due to large emboli which result in large cerebral vessel occlusion (LVO). This randomized control trial aims to address this unmet need by testing w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mercyhealth Javon Bea Hospital - Riverside, Rockford, Illinois

    Locations

    21 in total

    Run by

    Javelin Medical

    See if you can join NCT05723926 on ClinicalTrials.gov