Atrial Fibrillation Clinical Trials

64 studies are recruiting for atrial fibrillation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. The Fourth Left Atrial Appendage Occlusion Study

   LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arrhythmia Research Group, Jonesboro, Arkansas

   Locations

   150 in total

   Run by

   Hamilton Health Sciences Corporation

   See if you can join NCT05963698 on ClinicalTrials.gov

2. A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

   The purpose of this study is to assess how safe VARIPULSE pulsed field ablation (PFA) catheter is and how well it works compared to food and drug administration (FDA) approved FARAWAVE PFA catheter in participants with symptomatic persistent atrial fibrillation (PsAF; continuous irregular, rapid he…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Arrhythmia Research Group, Jonesboro, Arkansas

   Locations

   10 in total

   Run by

   Biosense Webster, Inc.

   See if you can join NCT07523750 on ClinicalTrials.gov

3. Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF

   Earlier studies have shown a dose-dependent relationship between alcohol intake and incident atrial fibrillation (AF) as well as a causal link with several risk factors for AF such as hypertension, obesity and sleep apnea. However, the effect of drinking (alcohol) on post-ablation outcome such as a…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas

   Run by

   Texas Cardiac Arrhythmia Research Foundation

   See if you can join NCT05510167 on ClinicalTrials.gov

4. High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation

   Patients undergoing FIRM guided ablation of atrial fibrillation will undergo high resolution MRI imaging to determine correlation of underlying anatomic fibrotic regions with FIRM targeted sites for ablation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT03444337 on ClinicalTrials.gov

5. ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

   This is a multi-national, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of etripamil NS in patients with atrial fibrillation (AF). This study includes Screening Visit, Randomization Visit, a Treatment Period with scheduled Follow-up Visits (Monthly Follow-…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Cardiovascular Associates Of The Delaware Valley, Haddon Heights, New Jersey

   Locations

   3 in total

   Run by

   Milestone Pharmaceuticals Inc.

   See if you can join NCT06716021 on ClinicalTrials.gov

6. CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation

   The primary objective of this Pivotal study is to demonstrate the safety and effectiveness of the Pulse Biosciences nsPFA™ Cardiac Surgery System in treating atrial fibrillation during concomitant cardiac surgical procedures.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Adventist Heart Institute: Adventist Health St. Helena, St. Helena, California

   Locations

   3 in total

   Run by

   Pulse Biosciences, Inc.

   See if you can join NCT06959121 on ClinicalTrials.gov

7. A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

   The main goal of this study is to find out how well BAY 3670549 works, how safe it is, how well people can tolerate it, and how the body handles the medicine. The study will compare BAY 3670549 to a placebo (a dummy treatment with no active medicine) in people with AF who need a treatment called el…

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Centro Cardiologico Monzino S.p.A. - UO Scompenso e Cardiologia Clinica, Milan,

   Locations

   29 in total

   Run by

   Bayer

   See if you can join NCT07625215 on ClinicalTrials.gov

8. Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

   This is a prospective multicenter clinical study comparing the efficacy of the Apple Watch AFib History tool to the iRhythm Zio Patch monitoring device in quantifying atrial fibrillation (AF) burden after surgical ablation. Patients with AF and mitral valve (MV) disease who undergo a Cox-Maze IV pr…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Washington University School of Medicine in St. Louis, St Louis, Missouri

   Locations

   2 in total

   Run by

   The Cleveland Clinic

   See if you can join NCT07122947 on ClinicalTrials.gov

9. Evaluation of 4D Intracardiac Echocardiography (ICE) During Structural Heart and Electrophysiology Procedures

   The purpose of this study is to evaluate the imaging performance and procedural safety of a prototype 4D ICE catheter during real-time intracardiac imaging and to optimize device imaging parameters, compared with current standard imaging modalities. TEE is the current standard of care and will serv…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinical Foundation, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07806890 on ClinicalTrials.gov

10. A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

    The purpose of this study is to evaluate the long-term safety and effectiveness of the FDA approved VARIPULSE catheter system for pulmonary vein isolation (PVI) in the treatment of participants with symptomatic paroxysmal atrial fibrillation (PAF).

    Stage

    Not phased

    Ages

    22 and older

    Site

    Phoenix Cardiovascular Research Group, Phoenix, Arizona

    Locations

    22 in total

    Run by

    Biosense Webster, Inc.

    See if you can join NCT07227532 on ClinicalTrials.gov

11. A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation

    The purpose of this study is to assess how safe VARIPULSE catheter system is for treatment of a heart rhythm disease called persistent atrial fibrillation (PsAF) in participants who are having a catheter ablation procedure (treat heart rhythm disease). This includes isolation of pulmonary vein and …

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Pima Heart and Vascular, Tucson, Arizona

    Locations

    3 in total

    Run by

    Biosense Webster, Inc.

    See if you can join NCT07527299 on ClinicalTrials.gov

12. The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

    REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in parti…

    Stage

    Phase 3

    Ages

    22 to 85

    Site

    Banner University, Phoenix, Arizona

    Locations

    93 in total

    Run by

    Johns Hopkins University

    See if you can join NCT05836987 on ClinicalTrials.gov

13. Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

    Atrial fibrillation (AF) affects 1 in 4 individuals during their lifetime and continues to increase in frequency and impact. Exercise intervention has established benefits to improve AF symptoms and burden in clinical studies. However, lack of access to exercise programs has limited therapeutic ado…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06938412 on ClinicalTrials.gov

14. NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

    The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascular disease in patients. It will also examine the safety and effectiveness of using this AI-based to…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06511505 on ClinicalTrials.gov

15. Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation

    Patients with atrial fibrillation (AF) who have had a prior stroke are at very high risk of recurrent ischemic stroke. About 40% of these strokes are due to large emboli which result in large cerebral vessel occlusion (LVO). This randomized control trial aims to address this unmet need by testing w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mercyhealth Javon Bea Hospital - Riverside, Rockford, Illinois

    Locations

    21 in total

    Run by

    Javelin Medical

    See if you can join NCT05723926 on ClinicalTrials.gov

16. PULSED AF Post-Approval Study

    PULSED AF PAS is a prospective, global, multi-center, non-randomized, observational trial. Subjects will be treated with the PulseSelect™ PFA System and followed through 36 months.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida Health (USF), Tampa, Florida

    Locations

    23 in total

    Run by

    Medtronic Cardiac Ablation Solutions

    See if you can join NCT06578104 on ClinicalTrials.gov

17. Longitudinal Validation of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07081711 on ClinicalTrials.gov

18. A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

    A randomized, placebo-controlled, participant-and investigator-blinded study to evaluate the efficacy in reducing atrial fibrillation burden as well as the safety, tolerability and pharmacokinetics of PKN605 in participants with atrial fibrillation

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cardiology Associates of North MS, Tupelo, Mississippi

    Locations

    40 in total

    Run by

    Novartis Pharmaceuticals

    See if you can join NCT07217067 on ClinicalTrials.gov

19. Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

    The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subjects with symptomatic paroxysmal and persistent atrial fibrillation using the pulsed field ablation …

    Stage

    Not phased

    Ages

    18 to 80

    Site

    St. Bernard's Heart and Vascular Center, Jonesboro, Arkansas

    Locations

    6 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06099730 on ClinicalTrials.gov

20. Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA

    The study is a prospective, exploratory observational study with the ECGenius® System and the PFAnalyzer software module in PFA cases using the FaraPulse PFA system. The cohort will be patients with paroxysmal or persistent atrial fibrillation (AF) who undergo PVI using this system.

    Stage

    Not phased

    Ages

    21 and older

    Site

    The Valley Hospital, Paramus, New Jersey

    Locations

    2 in total

    Run by

    CathVision ApS

    See if you can join NCT07275151 on ClinicalTrials.gov

21. Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation

    The purpose of the study is to see if the Sentinel® Cerebral Protection System may prevent occurrence of stroke during an ablation procedure for atrial fibrillation (AF). The secondary purpose of this study is to study if cognitive function after AF ablation differs between those treated with the S…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Malini Madhavan

    See if you can join NCT04685317 on ClinicalTrials.gov

22. HeartBeam ECG Registry

    The HeartBeam ECG Registry will collect ECG recordings acquired with the HeartBeam System with relevant clinical information in clinical settings.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Allegheny Health Network, Pittsburgh, Pennsylvania

    Run by

    HeartBeam, Inc.

    See if you can join NCT07501299 on ClinicalTrials.gov

23. Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

    Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multipl…

    Stage

    Not phased

    Ages

    20 to 90

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT04880265 on ClinicalTrials.gov

24. Tracking Results of Ablations to Combat AF Registry Generation 2

    The primary objective of the TRAC-AF Registry is to capture real-world safety and effectiveness data on AtriCure devices used to conduct open concomitant and/or hybrid ablation, and management of the LAA concomitant to a cardiac ablation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Huntsville Hospital, Huntsville, Alabama

    Locations

    29 in total

    Run by

    AtriCure, Inc.

    See if you can join NCT05111015 on ClinicalTrials.gov

25. Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

    The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated c…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    CHI St. Vincent, Arkansas, Little Rock, Arkansas

    Locations

    106 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT04045665 on ClinicalTrials.gov