Vascular Diseases Clinical Trials

27 studies are recruiting for vascular diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

   Background: Stroke is the fifth leading cause of death in the United States. It is also a leading cause of disability. More than 70% of people who survive strokes have mental impairment or dementia. Medical factors, such as the severity of the stroke, affect whether a person will have mental impair…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT06615973 on ClinicalTrials.gov

2. Factors Affect Outcomes in Cardiovascular Surgery

   Identify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass. Identify factors that affect perioperative morbidity and mortality in patients undergoing cardiac surgery.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California Davis Health System, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT01932411 on ClinicalTrials.gov

3. A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

   A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Clinical Research Site, Kissimmee, Florida

   Locations

   3 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07816185 on ClinicalTrials.gov

4. Thrombosis and Inflammation in Vessels Initiative (TIVI)

   Background: Diseases related to the immune system, blood clots, and blood vessels can affect every part of the body. These diseases are now known to be interrelated: People who have strokes, blood clots in their legs, or autoimmune disease, for example, are at greater risk of complications in the h…

   Stage

   Not phased

   Ages

   5 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT06552767 on ClinicalTrials.gov

5. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

   The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Minneapolis Heart Institute, Minneapolis, Minnesota

   Locations

   14 in total

   Run by

   Fundación EPIC

   See if you can join NCT07286578 on ClinicalTrials.gov

6. A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

   This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Clinical Research Site, Santa Barbara, California

   Locations

   13 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07333183 on ClinicalTrials.gov

7. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

   The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

   Stage

   Not phased

   Ages

   18 to 80

   Site

   MedStar Washington Hospital Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   Teleflex

   See if you can join NCT07258290 on ClinicalTrials.gov

8. Natural History of Stroke: Cause and Development

   The purpose of this study is to learn more about stroke and obtain information that may serve as the basis for future investigations. It will 1) establish a registry of patients with cerebrovascular disease (stroke); 2) characterize the natural history of acute stroke and transient ischemic attacks…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   Medstar Washington Hospital Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT00009243 on ClinicalTrials.gov

9. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

   The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Banner - University Medical Center Tucson, Tucson, Arizona

   Locations

   6 in total

   Run by

   Pulnovo Medical, Inc.

   See if you can join NCT07214376 on ClinicalTrials.gov

10. Global Paradise System US Post Approval Study

    The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tibor Rubin VA Medical Center, Long Beach, California

    Locations

    43 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT06297291 on ClinicalTrials.gov

11. SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery

    The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and markers of kidney and brain injury in patients having heart surgery. The main questions it aims to answer are: 1. Does soluble guanylyl cycla…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05812755 on ClinicalTrials.gov

12. The RADIANCE CED Study

    The RADIANCE CED study is a prospective observational study designed to evaluate the long-term effectiveness of ultrasound renal denervation in lowering blood pressure among patients with uncontrolled hypertension. Data will be collected from electronic health records (EHRs) of Medicare-eligible pa…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Locations

    2 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT07231757 on ClinicalTrials.gov

13. Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD)

    VahatiCor's Coronary Sinus Reducer (A-FLUX) has been designed to improve angina or angina-like symptoms in patients with CMD. SERRA-I is an early feasibility study that evaluates the safety and clinical performance of the A-FLUX Reducer in this population.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Locations

    3 in total

    Run by

    VahatiCor, Inc.

    See if you can join NCT07449325 on ClinicalTrials.gov

14. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Hospital and Clinics, Stanford, California

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

15. Examining the Use of Three Dimensional Ultrasound in the Assessment of Vascular Pathologies

    The ability to have a visual aid to depict areas of vascular disease that are affecting the patient's health can help in patient comprehension of the problem. This comprehension can lead to better understanding of the issue and increase patient compliance to treatment. The hand drawn sketch produce…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwell Health Comprehensive Wound Center, Lake Success, New York

    Run by

    Northwell Health

    See if you can join NCT05134311 on ClinicalTrials.gov

16. Treatment With Aspirin After Preeclampsia: TAP Trial

    The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a rand…

    Stage

    Phase 4

    Ages

    18 to 55

    Site

    University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania

    Run by

    Malamo Countouris

    See if you can join NCT06281665 on ClinicalTrials.gov

17. CLOSM Trial: Groin Closure Using Layered Option for Suture Material

    This is a randomized controlled trial comparing groin closure after vascular intervention with Vicryl suture versus PDS (polydioxanone) suture. This will be a single center trail performed at CCF main campus. Patients will be enrolled in a prospective fashion and will be randomized 1:1 to either PD…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06990425 on ClinicalTrials.gov

18. Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

    This observational study will assess the long-term effectiveness of the RDN procedure for lowering blood pressure in Medicare patients with uncontrolled hypertension. This research will be conducted using de-identified electronic health records (EHR) and administrative health insurance claims data.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Medtronic Vascular

    See if you can join NCT07174622 on ClinicalTrials.gov

19. Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

    AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps. The current Kardia family of devices can measure single lead and six limb-lead ECGs, depending on the device. KardiaMobile, KardiaMo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    4 in total

    Run by

    AliveCor

    See if you can join NCT06271577 on ClinicalTrials.gov

20. Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc

    The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a…

    Stage

    Not phased

    Ages

    55 to 70

    Site

    University of California, Davis; Department of Nutrition, Davis, California

    Run by

    University of California, Davis

    See if you can join NCT05236374 on ClinicalTrials.gov

21. Diabetic Neuropathy in Spinal Cord Stimulator Patients

    The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, im…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT04687215 on ClinicalTrials.gov

22. Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support

    Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of patients. In this study, the study team aims to investigate whether sildenaf…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT06510322 on ClinicalTrials.gov

23. Mechanisms of Pregnancy Vascular Adaptations

    The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of t…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    UnityPoint Health-Meriter Hospital, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT03806283 on ClinicalTrials.gov

24. Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

    Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy in KTRs may also re…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    University of Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05005793 on ClinicalTrials.gov

25. Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients

    Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the most common cause of death with a functioning graft. Sodium-glucose cotra…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06140537 on ClinicalTrials.gov