Tobacco Use Clinical Trials

32 studies are recruiting for tobacco use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Developing a Scalable Tobacco Cessation Program for Cancer Survivors and Caregivers

   Given the challenges to delivering tobacco cessation treatment in oncology care and the unique challenges faced by individuals attempting to quit tobacco after a cancer diagnosis, scalable cessation programs that are tailored to the experiences of cancer survivors that also integrate caregiver/fami…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06851936 on ClinicalTrials.gov

2. STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

   The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely ni…

   Stage

   Not phased

   Ages

   21 and older

   Site

   MUSC Charleston, Charleston, South Carolina

   Locations

   4 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT06922617 on ClinicalTrials.gov

3. Automating Tobacco Cessation in Primary Care

   This study focuses on improving how primary care teams identify patients who smoke and offer access to nicotine replacement therapy, or NRT. NRT includes medications such as nicotine patches, gum, or lozenges that can reduce cravings and support people who are interested in cutting back or quitting…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Penn Medicine, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07735286 on ClinicalTrials.gov

4. A Community Health Intervention to Improve Lung Cancer Screening Uptake in Community Health Centers

   Lung cancer screening (LCS) can reduce lung cancer-related mortality, but screening uptake remains low among eligible individuals. The goal of this study is to partner with community stakeholders to develop and pilot test a multi-component navigator-delivered intervention targeting key barriers to …

   Stage

   Not phased

   Ages

   50 to 80

   Site

   Baystate Health, Springfield, Massachusetts

   Run by

   Baystate Medical Center

   See if you can join NCT07168629 on ClinicalTrials.gov

5. Overcoming Nicotine Dependence to Enable Quitting

   Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers ar…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT05513872 on ClinicalTrials.gov

6. Cardiovascular Effects of Very Low Nicotine Content Cigarettes

   The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers

   Stage

   EARLY_Phase 1

   Ages

   21 and older

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT05707871 on ClinicalTrials.gov

7. A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

   The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey

   Locations

   8 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06693700 on ClinicalTrials.gov

8. Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

   The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco,…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06033599 on ClinicalTrials.gov

9. Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

   Using both tobacco and cannabis during pregnancy is more common in minoritized groups and can make quitting smoking in pregnancy and remaining smoke free postpartum difficult. Investigators will test an intervention to address prenatal depressive symptoms to encourage people to quit tobacco and can…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Bellefield Towers, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT07489443 on ClinicalTrials.gov

10. Little Cigar Oxidants

    Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups. These include a high oxidant little cigar exposure condition, a low oxidant little cigar exposur…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Penn State College of Medicine, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT06310187 on ClinicalTrials.gov

11. Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

    This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national sample of people unmotivated to quit smoking. Participants will be ra…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT07199517 on ClinicalTrials.gov

12. Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation

    This develops a novel behavioral tobacco cessation program for pregnant smokers in San Bernardino County.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Loma Linda University Medical Center, Loma Linda, California

    Locations

    2 in total

    Run by

    Loma Linda University

    See if you can join NCT06438549 on ClinicalTrials.gov

13. Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

    The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Connecticut Mental Health Center, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT06609369 on ClinicalTrials.gov

14. Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

    Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    San Francisco VA Medical Center, San Francisco, California

    Locations

    3 in total

    Run by

    University of California, San Francisco

    See if you can join NCT04722835 on ClinicalTrials.gov

15. The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

    Mobile health (mHealth) will be used for early detection of oral cancer and pre-cancer lesions, and to improve awareness of oral cancer among the population and knowledge of oral cancer diagnosis among frontline health providers. This program is inclusive of long term surveillance to downstage oral…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center (All protocol activites), New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06535867 on ClinicalTrials.gov

16. Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)

    This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and simulated tobacco use outcomes (quitting, switching) in various policy scenari…

    Stage

    Not phased

    Ages

    18 to 24

    Site

    University of Oklahoma Health Campus, Oklahoma City, Oklahoma

    Locations

    2 in total

    Run by

    University of Oklahoma

    See if you can join NCT07162935 on ClinicalTrials.gov

17. Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

    Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic r…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    The Pennsylvania State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT05572671 on ClinicalTrials.gov

18. Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes

    Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates. An "all or none" approach to smoking cessation in PWH offers little benefit to the large majority of PWH who are unable or unwill…

    Stage

    Not phased

    Ages

    40 to 79

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05642715 on ClinicalTrials.gov

19. RTMS Targets Neural Circuits for Smoking Cessation

    Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, i…

    Stage

    Not phased

    Ages

    22 to 70

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT04903028 on ClinicalTrials.gov

20. Effect of Cannabis on E-Cigarette Use Behavior

    The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired brea…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06609109 on ClinicalTrials.gov

21. Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

    This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be inst…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06372899 on ClinicalTrials.gov

22. The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

    This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tob…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06264154 on ClinicalTrials.gov

23. Effect of Cannabis on Cigarette Use Behavior

    The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon mon…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06609083 on ClinicalTrials.gov

24. Opioids, Low Nicotine Cigarettes, and Chronic Pain

    The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphi…

    Stage

    Not phased

    Ages

    21 and older

    Site

    North Pavilion, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06747871 on ClinicalTrials.gov

25. Oral Cannabidiol for Tobacco Cessation

    Cannabidiol is a compound found in cannabis plants that is well tolerated, has low abuse liability, and might be an effective medication to promote tobacco cessation. This clinical study will use a validated approach for screening tobacco cessation medications to determine if oral cannabidiol incre…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05445804 on ClinicalTrials.gov