Surgery Clinical Trials

45 studies are recruiting for surgery in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Sentinel Node Biopsy in Endometrial Cancer

   Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries \& if required a lymph node dissection (surgical staging)). While lymph node dissection …

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Houston Methodist Hospital, Houston, Texas

   Locations

   23 in total

   Run by

   Queensland Centre for Gynaecological Cancer

   See if you can join NCT04073706 on ClinicalTrials.gov

2. Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

   The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas

   Locations

   24 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05991453 on ClinicalTrials.gov

3. Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

   This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal A…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   8 in total

   Run by

   University of Michigan

   See if you can join NCT05722002 on ClinicalTrials.gov

4. AI-driven Clinical Decision Support for Perioperative Blood Orders

   20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is u…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University / Barnes Jewish Hospital, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07223853 on ClinicalTrials.gov

5. Continuous Versus Intermittent Ward Monitoring

   The investigators will randomize adults having major non-cardiac inpatient surgery to blinded versus unblinded continuous postoperative vital sign monitoring (saturation, ventilation, and heart rate). The investigators will use a wearable, untethered, and battery-powered sensor (Masimo Radius PPG, …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Hermann Hospital, Houston, Texas

   Locations

   2 in total

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT06232876 on ClinicalTrials.gov

6. Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

   The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or in…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Walter Reed National Military Medical Center, Bethesda, Maryland

   Run by

   Walter Reed National Military Medical Center

   See if you can join NCT07151417 on ClinicalTrials.gov

7. Optimizing Pain Self-Management in Total Knee Arthroplasty

   The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive em…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Fontaine Research Park, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT06038240 on ClinicalTrials.gov

8. NO During CPB in Neonates to Reduce Risk of AKI

   Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread succes…

   Stage

   Phase 3

   Ages

   0 to 0

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT04216927 on ClinicalTrials.gov

9. Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation

   Rotator cuff (RC) injuries are particularly prevalent, difficult to repair, and attachment between the bone and tendon is notoriously difficult to achieve. The most common method and current standard of care (SOC) for reattaching connective tissues (e.g., ligaments, tendons) to bone typically invol…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   10th Medical Group - Air Force Academy, Air Force Academy, Colorado

   Locations

   5 in total

   Run by

   Brooke Army Medical Center

   See if you can join NCT06289686 on ClinicalTrials.gov

10. Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND)

    The purpose of this study is to determine whether the implementation of existing neurosurgical techniques of intraoperative neuromonitoring (IONM) and the replacement of monopolar electrocautery with bipolar electrocautery (BE), during ALND, will improve the early identification of nerves that have…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Cincinnati, Cincinnati, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT07528638 on ClinicalTrials.gov

11. Adapting Enhanced Recovery Programs for Low Health Literacy Patients

    Low health literacy patients are a vulnerable population at high-risk for surgical disparities including longer hospital stays, more complications, and more readmissions. This study will adapt enhanced recovery programs (ERPs) to low health literacy patients with a multilevel, health literacy-based…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06356558 on ClinicalTrials.gov

12. A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

    The purpose of this study is to find out how many participants are interested in a surgical preventive procedure after watching an educational video. Before and after watching the video, participants will complete questionnaires in the clinic.

    Stage

    Not phased

    Ages

    45 and older

    Site

    Johns Hopkins University (Data Collection Only), Baltimore, Maryland

    Locations

    10 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06312124 on ClinicalTrials.gov

13. Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

    This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline mental health and poor physical function, improves satisfaction at 1-year (…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Cleveland Clinic Foundation, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06298721 on ClinicalTrials.gov

14. VR-Based Cognitive Stimulation Games for Delirium Prevention

    This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.

    Stage

    Not phased

    Ages

    Up to 65

    Site

    Houston Methodist Hospital, Houston, Texas

    Locations

    2 in total

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT07641153 on ClinicalTrials.gov

15. Regular Diet After Colorectal Surgery

    The goal of this pilot study is to assess the safety and feasibility of regular diet after surgical removal of the colon. The study will enroll patients preoperatively, prior to colon surgery, and will follow participants for up to 30 days. The study hypothesizes that simplifying nutritional recomm…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine-Section of Colon and Rectal Surgery, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07540845 on ClinicalTrials.gov

16. Impact of Uterine and Ovarian Vessel Occlusion on Blood Loss in High Burden Minimally Invasive Myomectomy.

    This study hypothesizes that temporary bilateral uterine and utero-ovarian artery occlusion with laparoscopic clamps at time of minimally invasive myomectomy will lead to a decreased blood loss at time of myomectomy compared to minimally invasive myomectomy without temporary occlusion.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Hermann Hospital, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT07182045 on ClinicalTrials.gov

17. Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis

    This study will be a prospective randomized study to evaluate the effect of tranexamic acid (TXA) use on intraoperative and postoperative outcomes among patients undergoing rhinoplasty by two Facial Plastic surgeons at Vanderbilt. Outcomes will include intra- and post-operative bleeding and postope…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05774717 on ClinicalTrials.gov

18. A Study of the Use of 3D Technology to Guide Head and Neck Surgery

    The purpose of this study is to test how the new 3D technology can be used to help improve the surgeon's ability to use information from standard imaging scans to guide head and neck surgery. Researchers will use the Scaniverse app during a standard ultrasound to create 3D images of participants' h…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering at Basking Ridge (Consent Only), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06676592 on ClinicalTrials.gov

19. Collecting Outcomes and Managing Pain After Surgery

    The primary aim of this study is to measure pain and psychosocial patient reported outcomes, objective functionality, and actual daily at home opioid usage in orthopedic patients. The study's goal following the data collection is to predict which patients are at high risk for chronic opioid use.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Duke Orthopaedics, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03834818 on ClinicalTrials.gov

20. Music Interventions During Wide-Awake Hand Surgery

    The purpose of this study is to examine if patients have a lower anxiety level during wide awake hand surgery while listening to their choice of music vs standardized relaxation music. Patients who are planning to undergo wide awake (local anesthetic only hand surgery) and agree to participate will…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT05472909 on ClinicalTrials.gov

21. The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

    The study is enrolling adults who are scheduled for either inpatient or outpatient elective surgical procedures at The University of Chicago. At pre-operative visits, patients will be consented and a blood sample will be obtained for preemptive genotyping across a panel of actionable germline varia…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT03729180 on ClinicalTrials.gov

22. The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

    Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes th…

    Stage

    Not phased

    Ages

    Any age

    Site

    Mass General Brigham Hospital Network of secondary, tertiary, and quaternary care hospitals, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07022951 on ClinicalTrials.gov

23. Neuralert Stroke Monitor Trial

    The Neuralert monitoring system, a non-invasive device worn on each wrist, is designed to provide continuous monitoring and expedited recognition of stroke by identifying asymmetry in the extremities, facilitating patient treatment and improving outcomes. This study is designed to evaluate the safe…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Neuralert Technologies LLC

    See if you can join NCT07362303 on ClinicalTrials.gov

24. INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients

    In this study, the investigators will evaluate the feasibility of the Wellness Program, including patient recruitment, screening and outcome measures, and feasibility of adapting the intervention with older Black surgical patients who endorse clinically significant symptoms of depression and/or anx…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07283783 on ClinicalTrials.gov

25. Evaluation of Resection Techniques for Pancreatic Tumors

    The objective of this study is to compare open and minimally invasive pancreatic and liver resection techniques and analyze the different outcome variables from the clinical standpoint. The plan is to investigate patient survival, length of stay, complication rates, operative time, transfusion rate…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Methodist Dallas Medical Center, Dallas, Texas

    Run by

    Methodist Health System

    See if you can join NCT05128890 on ClinicalTrials.gov