Suicide Clinical Trials

42 studies are recruiting for suicide in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

   The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Pittsburgh (UPMC), Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT06191484 on ClinicalTrials.gov

2. Army-SPRING Army-Suicide Prevention Research

   Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources and agencies. Suicide Intervention Officers need support in this diffic…

   Stage

   Phase 1

   Ages

   Any age

   Site

   Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania

   Locations

   3 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06547008 on ClinicalTrials.gov

3. Proximal Risk for Suicide in Adolescents

   The central hypothesis is that biometric data can continuously monitor and allow for early identification/intervention of escalating suicidal symptoms. The rationale is that improved outpatient monitoring through wearable technology can create a more objective platform to provide the ability to ide…

   Stage

   Not phased

   Ages

   13 to 17

   Site

   OHSU, Portland, Oregon

   Run by

   Oregon Health and Science University

   See if you can join NCT06400810 on ClinicalTrials.gov

4. Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis

   People with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on suicide. Emotion dysregulation is a significant suicidogenic factor tha…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Maryland, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05440214 on ClinicalTrials.gov

5. A Pilot Evaluation of a Digital Peer Support Intervention for Suicidal Adolescents

   Suicide risk has increased among youth in underserved communities, where access to mental healthcare is limited. To address this need, the investigator team plans to evaluate the preliminary efficacy of a brief, low-cost, culturally responsive digital intervention for ethnically diverse youth at ri…

   Stage

   Not phased

   Ages

   14 to 18

   Site

   Montefiore Health System, The Bronx, New York

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT06349915 on ClinicalTrials.gov

6. Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

   Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective. Researchers want to know if a faster-acting drug, (2R,6R)-hydroxynorketamine (HNK), can…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06511908 on ClinicalTrials.gov

7. NIMH Clinical Pathway in Rural Appalachian School-based Health Clinics

   This study will adapt and evaluate an evidence-based suicide risk screening and follow-up program in two school-based health centers in West Virginia. The suicide screening program is titled the "NIMH Clinical Pathway" and provides tools and procedures for routinely screening adolescents for suicid…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   West Virginia University, Morgantown, West Virginia

   Locations

   3 in total

   Run by

   West Virginia University

   See if you can join NCT06808503 on ClinicalTrials.gov

8. Natural History of Depression, Bipolar Disorder and Suicide Risk

   Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments. In this study, researchers want to perform tests on people undergoing clinical care for…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06462196 on ClinicalTrials.gov

9. Ketamine & Crisis Response Plan for Suicidal Ideation in the ED

   The goal of this randomized pilot trial is to assess the feasibility of administering a combination of 100mg intramuscular (IM) ketamine and Crisis Response Plan (a short psychosocial intervention) for patients with acute suicidality in the context of the Emergency Department setting. This study wi…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   University Hospital, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT05696691 on ClinicalTrials.gov

10. Intensive Crisis Intervention

    The study's purpose is to improve the clinical management of severe crises experienced by youth with psychiatric disorders by examining a brief, evidence-based alternative to inpatient psychiatric care.

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Nationwide Children's Hospital, Columbus, Ohio

    Run by

    Jennifer Hughes

    See if you can join NCT06476886 on ClinicalTrials.gov

11. Nudging Parental Actions for Youth Suicide Prevention

    The goal of the study is to determine effectiveness of a behaviorally informed text messaging intervention to help parents increase safety practices and reduce their teens' access to lethal means following a suicide-related emergency department visit.

    Stage

    Not phased

    Ages

    13 to 17

    Site

    Children's Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07383714 on ClinicalTrials.gov

12. Mobile Intervention for Suicidal Thoughts

    One of the factors that contributes to suicide risk is what is known as a "suicidal belief system." This belief system is made up of several cognitions that been associated with suicide risk among military personnel. Modification of these cognitions may reduce suicidal thoughts and behaviors. The s…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Durham VA Medical Center, Durham, NC, Durham, North Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT06593379 on ClinicalTrials.gov

13. Evaluation of a Telehealth Case Management Intervention to Prevent Suicide Among Soldiers Discharged From Psychiatric Hospitalization

    This study evaluates the effectiveness of Pathfinding, a 6-month, remotely-delivered case management intervention designed to decrease suicidal behavior among active-duty Regular Army soldiers recently discharged from inpatient psychiatric treatment. Soldiers discharged from military treatment faci…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Uniformed Services University of the Health Sciences, Bethesda, Maryland

    Run by

    Uniformed Services University of the Health Sciences

    See if you can join NCT07404787 on ClinicalTrials.gov

14. Caring Connections Youth Suicide Detection and Intervention Study

    The goal of this pilot randomized control trial (RCT) is to test the feasibility of Caring Connections, a Culturally Adapted Linking Individuals Needing Care (CA-LINC) suicide prevention care coordination intervention for high-risk suicidal youth. This consumer-, community-, and theory-driven care …

    Stage

    Not phased

    Ages

    13 and older

    Site

    The University of North Carolina at Charlotte, Charlotte, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06353711 on ClinicalTrials.gov

15. Mobile Technology to Reduce Teen Substance Misuse

    The goal of this study is to test the newly expanded WisePath for Teens (WPT) for substance use app, a direct-to-consumer paired mobile phone app for iOS and Android platforms that supports parents/guardians in delivering evidence-based techniques to reduce youth substance abuse and co-occurring me…

    Stage

    Not phased

    Ages

    13 and older

    Site

    University of Maryland, Baltimore, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Evidence-Based Practice Institute, Seattle, WA

    See if you can join NCT05897164 on ClinicalTrials.gov

16. Mental Health in Primary Care

    The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary car…

    Stage

    Not phased

    Ages

    12 to 16

    Site

    Mailman for Child Devlopment, Miami, Florida

    Locations

    17 in total

    Run by

    University of Miami

    See if you can join NCT05426057 on ClinicalTrials.gov

17. Pilot Study of Health System/Community Partnership for Enhanced Outreach to Prevent Suicide Attempts

    The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an emergency department (ED) visit for suicidal thoughts. The main questions …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05825820 on ClinicalTrials.gov

18. A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

    Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to increase engagement with effective interventions such as suicid…

    Stage

    Not phased

    Ages

    13 to 24

    Site

    STAR Center, Western Psychiatric Institute & Clinic, Pittsburgh, Pennsylvania

    Locations

    3 in total

    Run by

    Ksana Health

    See if you can join NCT07348666 on ClinicalTrials.gov

19. Warrior CARE: Cannabis Behavioral Health

    This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.

    Stage

    Phase 1

    Ages

    19 to 69

    Site

    Wayne State University, Detroit, Michigan

    Run by

    Wayne State University

    See if you can join NCT06381180 on ClinicalTrials.gov

20. Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

    This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depress…

    Stage

    Not phased

    Ages

    10 to 24

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05437588 on ClinicalTrials.gov

21. Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

    The study will compare the effectiveness of two relatively brief and scalable evidence-based interventions: the Stanley Brown Safety Planning Intervention and Follow-up Contacts (SPI+), a suicide-specific intervention that helps people prevent suicidal crises from escalating, and Interpersonal Psyc…

    Stage

    Not phased

    Ages

    12 to 24

    Site

    Johns Hopkins All Children's Hospital, St. Petersburg, Florida

    Locations

    6 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06151158 on ClinicalTrials.gov

22. Sleep and Circadian Interventions for College Students at High Risk of Suicide

    The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide risk among high risk young adults. Investigators will evaluate three …

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07346014 on ClinicalTrials.gov

23. Scaling up e-Connect in Juvenile Probation Settings

    We propose to conduct research on strategies that support the successful scale-up of an evidence-based, suicidal risk and behavior identification and cross-system linkage programs for justice-involved youth (e-Connect), and to rigorously evaluate the implementation activities and associated costs t…

    Stage

    Not phased

    Ages

    10 and older

    Site

    Columbia University and New York State Psychiatric Instititute, New York, New York

    Run by

    New York State Psychiatric Institute

    See if you can join NCT05541926 on ClinicalTrials.gov

24. Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

    The primary aim of this project are to evaluate a comprehensive, practice-ready, and deployment-focused strategy for improving the prediction and prevention of suicide attempts among a sample of 4,000 patients presenting to an ED with a psychiatric concern. The first aim is to evaluate the effects …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05671133 on ClinicalTrials.gov

25. Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

    The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prev…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06963463 on ClinicalTrials.gov