Suicidal Ideation Clinical Trials

49 studies are recruiting for suicidal ideation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Reward Sensitivity Digital Intervention for Suicide Risk

   The goal of this clinical trial is to develop and test an app designed to reduce suicide risk and improve emotional well-being in adolescents. The study will test if the app's daily check ins and recommended mood boosting skills will improve the adolescent's overall mood and suicidality. The main q…

   Stage

   Not phased

   Ages

   13 to 17

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07661901 on ClinicalTrials.gov

2. Pilot Study of Health System/Community Partnership for Enhanced Outreach to Prevent Suicide Attempts

   The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an emergency department (ED) visit for suicidal thoughts. The main questions …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05825820 on ClinicalTrials.gov

3. Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

   This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of …

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Pine Rest Christian Mental Health Services, Grand Rapids, Michigan

   Run by

   Michigan State University

   See if you can join NCT06529029 on ClinicalTrials.gov

4. Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults

   The goal of this clinical trial is to learn whether a novel digital avatar (virtual coach) support program can help emerging adults ages 18-29 who present to the emergency department with suicidal thoughts and alcohol misuse (EA-Avatar). The study also aims to learn whether people find the program …

   Stage

   Not phased

   Ages

   18 to 29

   Site

   UMass Memorial Health - Marlborough Hospital, Marlborough, Massachusetts

   Locations

   2 in total

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT07418047 on ClinicalTrials.gov

5. RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

   In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy …

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Medical Univeristy of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05977439 on ClinicalTrials.gov

6. Improving Coping to Reduce Suicide Risk Following ED Discharge

   The researchers hope to learn whether an electronic safety plan (ESP) and a supportive text messaging program are feasible and acceptable to adult patients with recent suicidal thoughts or behavior after emergency department (ED) discharge. From this study, the researchers also hope to learn how to…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06614946 on ClinicalTrials.gov

7. Walk With Me (WWM) for Perinatal Grief

   The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on t…

   Stage

   Not phased

   Ages

   15 and older

   Site

   Oregon Research Behavioral Intervention Strategies, Inc., Eugene, Oregon

   Locations

   2 in total

   Run by

   Oregon Research Behavioral Intervention Strategies, Inc.

   See if you can join NCT07011940 on ClinicalTrials.gov

8. A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness

   Suicide is a major public health concern, particularly among Veterans with serious mental illness (SMI, i.e., psychotic disorders or bipolar disorders). Wellness Recovery Action Plan (WRAP) is a well-established evidence-based practice for those with SMI that centers on identifying warning signs of…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT05537376 on ClinicalTrials.gov

9. Sleep Treatment for Teens (RCT Phase)

   The purpose of this research study is to compare (vs. treatment as usual) a brief (6-session), empirically supported, and highly disseminable version of digital (i.e., smartphone or web-based) cognitive behavioral therapy for insomnia (dCBT-I), called SleepioTM, in suicidal adolescents with co-occu…

   Stage

   Not phased

   Ages

   14 to 18

   Site

   Rutgers University Behavioral Healthcare, Piscataway, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT07303959 on ClinicalTrials.gov

10. Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents

    The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents. The specific aims are to: Aim #1: Conduct a randomized controlled trial (RCT) comparing Flourish+Qu…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT06002191 on ClinicalTrials.gov

11. Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

    The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06285708 on ClinicalTrials.gov

12. Recovery Through Inspiration, Support, and Empowerment

    The goal of this pilot study is to test the effectiveness of a novel intervention for young adults (ages 18-27) with mental health conditions who have been released from an acute care psychiatric facility. The intervention aims to reduce suicidality, depression, anxiety, re-hospitalization, and imp…

    Stage

    Not phased

    Ages

    18 to 27

    Site

    The University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07051200 on ClinicalTrials.gov

13. Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

    The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measur…

    Stage

    Not phased

    Ages

    13 to 21

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05652153 on ClinicalTrials.gov

14. WeCare: A System of Care for Black Youth

    The overall goal of this study is to respond to the urgent need for an effective suicide prevention strategy for Black youth by examining the effectiveness of a systems-level strategy to recognize and respond to suicide risk among Black adolescents who present to emergency departments (EDs). The pr…

    Stage

    Not phased

    Ages

    12 to 19

    Site

    Kings County Hospital, New York, New York

    Run by

    New York University

    See if you can join NCT05654207 on ClinicalTrials.gov

15. Transition Health and Resilience Through Valued Experiences (THRiVE) Pilot for Newly Separated Veterans

    The objective of this study is to develop and pilot a program designed to improve mental health outcomes and reduce suicide risk during the transition from military to civilian life. It is hypothesized that the Transition Health and Resilience through Valued Experiences (THRiVE) program, to be deve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    RTI International, Durham, North Carolina

    Run by

    RTI International

    See if you can join NCT06778278 on ClinicalTrials.gov

16. Mind After Midnight

    This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    University of Arizona - Center for Sleep, Circadian, and Neuroscience Research, Tucson, Arizona

    Run by

    University of Arizona

    See if you can join NCT07438912 on ClinicalTrials.gov

17. Integrated Suicide Supports and Safety Planning for Youth

    The goal of this clinical trial is to evaluate an app to help keep teens and young adults with suicidal thoughts safe. The app includes a safety plan created by adolescents and healthcare providers, and videos to encourage supportive communication and skills for teens and young adults to stay safe.…

    Stage

    Not phased

    Ages

    13 to 21

    Site

    Seattle Children's Hospital, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06701006 on ClinicalTrials.gov

18. The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

    The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05786066 on ClinicalTrials.gov

19. Intensive Case Management Between VA and Community Care for Suicide Prevention

    The goal of this randomized clinical trial is to build the evidence base for SUPERCEDE, a suicide prevention focused intensive case management intervention to increase access, improve care coordination, provide suicide prevention monitoring, and procure a timely response of VA mental health and sui…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Eastern Colorado Healthcare System, Aurora, Colorado

    Run by

    VA Eastern Colorado Health Care System

    See if you can join NCT07534358 on ClinicalTrials.gov

20. Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

    There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who p…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of Kansas Medical Center Emergency Department, Kansas City, Kansas

    Locations

    2 in total

    Run by

    Lindsay Maguire, MD

    See if you can join NCT06085937 on ClinicalTrials.gov

21. Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury

    The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI). These conditions have been shown to be linked. The investigators are using a hig…

    Stage

    Phase 1

    Ages

    22 to 65

    Site

    Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois

    Run by

    VA Office of Research and Development

    See if you can join NCT05647044 on ClinicalTrials.gov

22. Emerging Technologies and Teen Mental Health

    This study will recruit teens who are experiencing subacute suicidal ideation to test the effect of a brief psychoeducational intervention focused on social media use wherein youth learn about active and prosocial use of social media platforms.

    Stage

    Not phased

    Ages

    12 to 17

    Site

    FIU Center for Children and Families, Miami, Florida

    Run by

    Florida International University

    See if you can join NCT07527052 on ClinicalTrials.gov

23. Flourish in Schools Pilot Study

    This study will test Flourish, a digital suicide prevention intervention for cyberbullied youth, within schools. Specifically, the study aims to: 1. Examine if Flourish is effective and can be feasibly delivered within schools among middle and high school students who are experiencing cyberbullying…

    Stage

    Not phased

    Ages

    11 to 21

    Site

    Bay Village School District, Bay Village, Ohio

    Locations

    2 in total

    Run by

    Candice Biernesser

    See if you can join NCT07506525 on ClinicalTrials.gov

24. MicroRNA Correlates of Childhood Maltreatment and Suicidality

    This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04923685 on ClinicalTrials.gov

25. Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

    The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.

    Stage

    Not phased

    Ages

    50 to 80

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05925322 on ClinicalTrials.gov