Substance Use Clinical Trials

40 studies are recruiting for substance use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Primary Connections for Youth and Families

   The goal of this clinical trial is to compare a standard adolescent-only approach to substance use screening, brief intervention, and referral to treatment to a in primary care settings. Primary outcomes (AOD use, co-occurring behavior problems, parent-youth communication about AOD use) and seconda…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Columbia University Medical Center, New York, New York

   Run by

   The National Center on Addiction and Substance Abuse at Columbia University

   See if you can join NCT05964010 on ClinicalTrials.gov

2. Open-Label Psilocybin Study in Transdiagnostic Population

   The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06442423 on ClinicalTrials.gov

3. Native Spirit: Significant Aim 3: Intervention

   The proposed research will used community-based participatory research methods in an urban-based American Indian (AI) community to adapt, implement, and evaluate an after-school program, called Native Spirit (NS), that seeks to improve cultural identity, self-esteem, resilience, and prevent substan…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Way of Life Facility, Scottsdale, Arizona

   Locations

   2 in total

   Run by

   Arizona State University

   See if you can join NCT06785311 on ClinicalTrials.gov

4. Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

   Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "conti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rogers Behavioral Health, Oconomowoc, Wisconsin

   Locations

   2 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04927143 on ClinicalTrials.gov

5. M2VA Pain Care Pathway

   The goal of this 2-cohort, cluster randomized, type 2 hybrid trial is to test the effectiveness, cost-effectiveness and patient-level effects of an implementation facilitation strategy in helping M2VA case managers adopt a Military2VA Pain Care Pathway (M2VAPCP) intervention. The main questions it …

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Connecticut Healthcare System (VACHS), West Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06526143 on ClinicalTrials.gov

6. Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

   This randomized Type 1 hybrid effectiveness-implementation trial (N=186) will evaluate the effectiveness and implementation of a peer-delivered problem solving and behavioral activation intervention for adherence to LAI-PrEP/ART ("Peer Activate-LAI") compared to enhanced treatment as usual (ETAU) f…

   Stage

   Not phased

   Ages

   18 to 88

   Site

   HIPS (Harm reduction drop-in center), Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06501781 on ClinicalTrials.gov

7. A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

   The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300 middle and high school students, who have violated their school substance u…

   Stage

   Not phased

   Ages

   9 to 22

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06115746 on ClinicalTrials.gov

8. An Evaluation of the Pink Cloud Application in Post- Treatment Substance Use Disorder Support

   This randomized controlled trial (RCT) will evaluate the feasibility and efficacy of Pink Cloud, a mobile health application designed to support recovery from substance and alcohol use disorders (SUD/AUD). The app provides access to over 245,000 in-person and virtual 12-Step meetings, along with fe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Loyola Marymount, Los Angeles, California

   Run by

   Loyola Marymount University

   See if you can join NCT07042451 on ClinicalTrials.gov

9. ANCHORS Alcohol & Sexual Health Study: UH3 Project

   80 young adult men will complete an initial survey and receive 1 of 2 types of alcohol and sexual health education and information to encourage prevention of alcohol-related problems, HIV and other sexually transmitted infections (STIs). Participants will then take pre-exposure prophylaxis (PrEP) f…

   Stage

   Phase 4

   Ages

   18 to 30

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT04331704 on ClinicalTrials.gov

10. Adverse Adolescent Pathways to Substance Use

    Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anx…

    Stage

    Not phased

    Ages

    12 to 14

    Site

    The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06977178 on ClinicalTrials.gov

11. Parent SMART (Substance Misuse in Adolescents in Residential Treatment)

    Adolescents in residential substance use treatment have serious substance-related problems and poor outcomes following discharge: follow-up studies indicate that 60% of adolescents treated in residential treatment will relapse within the first 90 days. Parenting practices have been established as a…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Rosecrance Health Network, Rockford, Illinois

    Locations

    3 in total

    Run by

    Brown University

    See if you can join NCT05169385 on ClinicalTrials.gov

12. Teen Health Choices & Wellness

    The goal of this observational study is to learn more about changes in health, wellness, and substance-use behaviors as teenagers get older. Participants, ages 13 to 16, will be asked to use a smartphone application developed for this research study. Participants will also come to Brown University …

    Stage

    Not phased

    Ages

    13 to 16

    Site

    Brown University School of Public Health, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT06822569 on ClinicalTrials.gov

13. Pre-exposure Prophylaxis (PrEP) Adherence Intervention for Women with Substance Use Disorders

    The goal of this clinical trial is to test an addiction-clinic based behavioral intervention for increasing PrEP uptake and adherence among women who engage in high-risk sexual behaviors and problematic substance use. The main question it aims to answer is: • If the integrated intervention increase…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06158607 on ClinicalTrials.gov

14. Pre-exposure Prophylaxis (PrEP) Uptake and Adherence Intervention for Women with Trauma-related Conditions

    The investigators have previously developed an integrated bio-behavioral intervention to promote PrEP uptake and adherence in cisgender women who are undergoing treatment for trauma-related mental health conditions and who are at a higher risk for HIV. The intervention is delivered within the menta…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06558825 on ClinicalTrials.gov

15. Health and Resilience Projects: Foundations

    The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents. Youth age 10-13 and their primary caregivers are randomly assigned to receive SAAF …

    Stage

    Not phased

    Ages

    10 to 13

    Site

    Center for Family Research, Athens, Georgia

    Run by

    University of Georgia

    See if you can join NCT05253235 on ClinicalTrials.gov