Substance Use Clinical Trials

40 studies are recruiting for substance use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

   This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples M…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Hunter College, New York, New York

   Locations

   3 in total

   Run by

   Hunter College of City University of New York

   See if you can join NCT06307977 on ClinicalTrials.gov

2. Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Stage

   Not phased

   Ages

   12 to 20

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   23 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05541406 on ClinicalTrials.gov

3. Parenting in 2 Worlds Multisite Trial

   This research study will test the effectiveness of a culturally grounded parenting intervention called Parenting in 2 Worlds (P2W). This intervention is designed for American Indian / Alaska Native (AI) parents/guardians of adolescents who reside in urban areas. This will be a multi-regional effect…

   Stage

   Phase 2

   Ages

   12 and older

   Site

   Phoenix Indian Center, Phoenix, Arizona

   Locations

   4 in total

   Run by

   Arizona State University

   See if you can join NCT06324318 on ClinicalTrials.gov

4. Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors

   The ASSIST Study is designed to explore whether a brief, evidence based substance use screening and counseling approach can be easily integrated into routine survivorship care at St. Jude Children's Research Hospital. During a regularly scheduled psychosocial visit, participants complete the World …

   Stage

   Not phased

   Ages

   15 and older

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07516301 on ClinicalTrials.gov

5. Mobile Technology to Reduce Teen Substance Misuse

   The goal of this study is to test the newly expanded WisePath for Teens (WPT) for substance use app, a direct-to-consumer paired mobile phone app for iOS and Android platforms that supports parents/guardians in delivering evidence-based techniques to reduce youth substance abuse and co-occurring me…

   Stage

   Not phased

   Ages

   13 and older

   Site

   University of Maryland, Baltimore, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Evidence-Based Practice Institute, Seattle, WA

   See if you can join NCT05897164 on ClinicalTrials.gov

6. Linking Individuals Needing Care for Substance Use Disorders to Peer Coaches & Across INcarceration Settings

   The goal of this study is to learn whether a virtual peer recovery coach (PRC) intervention can improve engagement in addiction treatment among incarcerated adults with substance use disorders. The main questions it aims to answer are: * Does the PRC intervention increase engagement with at least o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Atlanta City Detention Center, Atlanta, Georgia

   Locations

   3 in total

   Run by

   Emory University

   See if you can join NCT07563517 on ClinicalTrials.gov

7. CARS: Cannabis and Alcohol Reduction Study

   The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.

   Stage

   Not phased

   Ages

   13 to 17

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05486234 on ClinicalTrials.gov

8. Testing and Evaluation of the Returning to the Land Intervention to Address and Prevent Substance Misuse

   This study aims to test the Returning to the Land intervention in partnership with a tribal community. The program is designed to address caregiver substance use and child emotional and behavioral development.

   Stage

   Not phased

   Ages

   14 to 19

   Site

   Rocky Boy Health Center, Box Elder, Montana

   Run by

   Johns Hopkins Bloomberg School of Public Health

   See if you can join NCT07695818 on ClinicalTrials.gov

9. iPAWS: Improving Pain Management After Wisdom Tooth Extraction Surgery

   This is a clinical trial that will evaluate the feasibility and acceptability of a virtual brief program for adolescents and young adults undergoing wisdom tooth extraction and their parents. The program aims to teach youth safe and effective ways to manage post-surgical pain as well as decrease ri…

   Stage

   Not phased

   Ages

   15 to 20

   Site

   Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island

   Run by

   Brown University

   See if you can join NCT07731295 on ClinicalTrials.gov

10. Cultural Adaptation of Drug Treatment for DJJ Youth

    This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and focus groups with parents and guardians of Black J…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    University of California, San Francisco, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06003725 on ClinicalTrials.gov

11. Neuroimaging of Adolescent Cannabis Use Treatment

    This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete d…

    Stage

    Not phased

    Ages

    14 to 17

    Site

    Indiana University School of Medicine, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07340554 on ClinicalTrials.gov

12. Finding Emotional Empowerment and Lifelong Strength

    This study will build a partnership with a Community Advisory Board to co-produce, and then pilot test, a theory-guided mental health literacy intervention focused on trauma and substance use. Participants will take part in educational group sessions for 12 weeks and complete assessments at baselin…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Center of Alcohol & Substance Use Studies, Piscataway, New Jersey

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT07378254 on ClinicalTrials.gov

13. Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

    This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: - A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward pr…

    Stage

    Not phased

    Ages

    18 to 22

    Site

    Rachel Upjohn Building, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    University of Michigan

    See if you can join NCT07094061 on ClinicalTrials.gov

14. Adaptation and Evaluation of Bright Horizons

    This study will test if a program called 'Bright Horizons' is effective at reducing binge substance use among adolescents. Bright Horizons is a culturally adapted intervention developed and tested through a partnership between The White Mountain Apache Tribe and Johns Hopkins University. Bright Hor…

    Stage

    Not phased

    Ages

    10 to 24

    Site

    Johns Hopkins Center for Indigenous Health - Whiteriver Site, Whiteriver, Arizona

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT05743699 on ClinicalTrials.gov

15. The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth

    The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims. AIM 1 (Years 1-3) are focused on pre-intervention and intervention development. In Year 1, youth focus …

    Stage

    Not phased

    Ages

    10 to 14

    Site

    University of Hawaii, Honolulu, Hawaii

    Run by

    University of Hawaii

    See if you can join NCT06929520 on ClinicalTrials.gov

16. Project REACH: A Comprehensive Telehealth Intervention at Syringe Service Programs to Engage People Who Use Drugs

    This trial will assess the feasibility, acceptability, and preliminary effectiveness of Project REACH (Remote Engagement \& Access for Community Health), a telehealth intervention at syringe service programs (SSP) to improve access to HIV-related evidence-based interventions (EBI) for people who us…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07433712 on ClinicalTrials.gov

17. The Collaborative Care PrTNER Study

    A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among yo…

    Stage

    Not phased

    Ages

    15 to 29

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06585631 on ClinicalTrials.gov

18. The Hastiin Bidziil (Strong Man) Intervention

    The Hastiin Bidziil (Strong man) Intervention study is part of a larger project called, Community-Driven Indigenous Research, Cultural Strengths \& Leadership to Advance Equity in Substance Use Outcomes (CIRCLE) Center of Excellence. CIRCLE aims to address drug use related health problems in collab…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Navajo Nation Center for Indigenous Health - Chinle, Chinle, Arizona

    Locations

    2 in total

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT06559774 on ClinicalTrials.gov

19. Women Focused Encounters for Resilience Independence Strength and Eudaimonia

    The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS/HIV (SAVA) to improve medication adherence for wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC San Diego AntiViral Research Center (AVRC), San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06216600 on ClinicalTrials.gov

20. J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

    The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system. The main question it aims to answer is: • Compared with the Health Navigation group, are participants in the Health N…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06477588 on ClinicalTrials.gov

21. Family Spirit Strengths

    This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigat…

    Stage

    Not phased

    Ages

    14 and older

    Site

    Johns Hopkins Center for Indigenous Health, Chinle, Arizona

    Locations

    3 in total

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT05836090 on ClinicalTrials.gov

22. Enhancing Wellness Through Affirming Services and Education

    The goal of this treatment study is to learn about the mental health, substance use and physical health outcomes associated with participating in the EASE holistic behavioral health and wellness program for individuals seeking HIV prevention and/or living with HIV. The main questions it aims to ans…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Susan Reif, Charlotte, North Carolina

    Run by

    Duke University

    See if you can join NCT05700474 on ClinicalTrials.gov

23. MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

    The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to alcohol-related pictures. TMS and TBS are stimulation techniques that use magn…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT04998916 on ClinicalTrials.gov

24. Gii'Igoshimong: Sitting With Your First Family

    The goal of this randomized wait-list control study is to understand the relationship between ceremony and substance use (SU), SU risk (e.g., SU severity, depressive symptoms) and protective factors (e.g., spirituality, community support). The main questions it aims to answer are: * Will adults enr…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Great Lakes Hub, Duluth, Minnesota

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT07075081 on ClinicalTrials.gov

25. A Regional Partnership to Improve Outcomes Through Fatherhood Engagement

    Montefiore will engage fathers in families at risk of substance misuse in the Bronx and neighboring communities. Families will be referred from Bronx and neighboring community-based child welfare systems, substance use disorder (SUD) treatment providers, and medical providers if identified at risk …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05562557 on ClinicalTrials.gov