Spinal Cord Injury Clinical Trials

46 studies are recruiting for spinal cord injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. At-Home Genital Nerve Stimulation for SCI Bowel

   The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries. Current bowel treatments either involve diet and medications or surgery. This study will eva…

   Stage

   Not phased

   Ages

   18 and older

   Site

   MetroHealth Center for Rehabilitation Research, Cleveland, Ohio

   Run by

   MetroHealth Medical Center

   See if you can join NCT06836739 on ClinicalTrials.gov

2. Understanding and Enhancing Human Health and Movement

   By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclero…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

   Run by

   Louis Stokes VA Medical Center

   See if you can join NCT07738978 on ClinicalTrials.gov

3. Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury

   Spasticity is a common consequence of spinal cord injury and can have a profound impact on quality of life. The goal of this study is to learn if an intervention called focused extracorporeal shockwave therapy can enhance the effectiveness of injections received for spasticity, such as Botox. The m…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT07894991 on ClinicalTrials.gov

4. A Neuroprosthesis for Seated Posture and Balance

   The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips. FES involves applying small electric currents to the nerves, which cause the muscles to contract. This study evaluates how stabilizing and st…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio

   Run by

   VA Office of Research and Development

   See if you can join NCT01474148 on ClinicalTrials.gov

5. Augmenting Upper Limb Function and Functional Neuroplasticity Using Epidural Stimulation of the Cervical Spinal Cord

   This study will test whether spinal stimulation combined with rehabilitation can improve arm and hand function in people with tetraplegia after spinal cord injury. Tetraplegia causes weakness or paralysis in the arms and legs. The stimulation sends electrical pulses through a paddle placed near the…

   Stage

   Not phased

   Ages

   22 to 70

   Site

   The Methodist Hospital Research Institute, Houston, Texas

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT06225245 on ClinicalTrials.gov

6. Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic

   Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at high risk of pressure injury (PrI) throughout their lives due to loss of sensation, nerve damage and immobility. PrIs a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California

   Locations

   8 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06529094 on ClinicalTrials.gov

7. Fermented Foods and Bowel Health in SCI

   The goal of this clinical trial is to learn whether consuming a high fermented food diet improves bowel function and gut health in adults with chronic spinal cord injury (SCI). The study will also evaluate the feasibility and tolerability of consuming fermented foods daily for 10 weeks. The main qu…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07640152 on ClinicalTrials.gov

8. Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury

   Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands. One of the consequences of SCI is spasticity - involuntary activation of muscles that can hinde…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT07501429 on ClinicalTrials.gov

9. Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait

   This research aims to understand the effect of the Neuro20 Functional Electrical Stimulation Suit on autonomic nervous system function, muscle performance, and gait after amputation or neurologic injury.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brooks Rehabilitation, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Brooks Rehabilitation

   See if you can join NCT07164846 on ClinicalTrials.gov

10. Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury

    This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tra…

    Stage

    Phase 2

    Ages

    19 to 85

    Site

    Shirley Ryan Abilitylab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT07814313 on ClinicalTrials.gov

11. Vibratory Genital Nerve Stimulation (vGNS) to Treat Female Sexual Dysfunction (FSD) After Spinal Cord Injury (SCI)

    The goal of this clinical trial is to learn if vibratory genital nerve stimulation (vGNS) can improve sexual function in women with spinal cord injury. The main question it aims to answer is: Does acute vGNS increase genital blood flow during a standardized sexual arousal assessment, as measured by…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Hennepin Healthcare Research Institute, Minneapolis, Minnesota

    Run by

    Samuel Cramer

    See if you can join NCT07870642 on ClinicalTrials.gov

12. Time Comparison of Interventions on Bowel Programs in Spinal Cord Injury

    The goal of the study is to find out which of three different options (a suppository, a mini enema, or a transanal irrigation device) takes the least amount of time for completing bowel program amongst those who have spinal cord injuries with a neurogenic bowel. The main questions this study aims t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Casa Colina Hospital and Centers for Healthcare, Pomona, California

    Run by

    Casa Colina Hospital and Centers for Healthcare

    See if you can join NCT07817199 on ClinicalTrials.gov

13. Testosterone and Neural Function in Men With Spinal Cord Injury

    Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS). Testosterone (T) plays a significant role in brain health and ANS reflex function in non-neurologically imp…

    Stage

    EARLY_Phase 1

    Ages

    18 to 80

    Site

    James J. Peters VA Medical Center, Bronx, NY, The Bronx, New York

    Run by

    VA Office of Research and Development

    See if you can join NCT06130449 on ClinicalTrials.gov

14. Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

    The purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders. The study investigates the effects of wearing the device during a set of experiments including leg stretching…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Syracuse VA Medical Center, Syracuse, NY, Syracuse, New York

    Run by

    VA Office of Research and Development

    See if you can join NCT05926596 on ClinicalTrials.gov

15. The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

    To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer tra…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Locations

    8 in total

    Run by

    AO Foundation, AO Spine

    See if you can join NCT06839300 on ClinicalTrials.gov

16. CBD for Lower Urinary Tract Dysfunction in Spinal Cord Injury

    The goal of this feasibility study is to learn whether Cannabidiol (CBD) can improve urinary incontinence and other symptoms in people with recent spinal cord injury (SCI). Participants will take Epidiolex (purified CBD) for 90 days

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Wisconsin - Madison, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06840899 on ClinicalTrials.gov

17. mSCI: Mobile Health App for Veterans With SCI and Caregivers

    Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation. Military caregivers (Family Caregivers of wounded or disabled Veterans) reported simil…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07269977 on ClinicalTrials.gov

18. Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury

    The purpose of this study is to find out whether insulin, a drug approved by the FDA for the treatment of diabetes mellitus, is safe when administered as a nasal spray (intranasally) to people who have experienced a spinal cord injury. While insulin nasal spray has been shown to be safe in many pat…

    Stage

    Phase 1

    Ages

    18 to 84

    Site

    HealthPartners Neuroscience Center, Saint Paul, Minnesota

    Run by

    HealthPartners Institute

    See if you can join NCT07384052 on ClinicalTrials.gov

19. Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction

    The goal of this study is to test the safety and effectiveness of Vibrant capsules in spinal cord injury patients with neurogenic bowel.

    Stage

    Not phased

    Ages

    21 and older

    Site

    TIRR Memorial Hermann, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT07213986 on ClinicalTrials.gov

20. Male Fertility Program

    Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen abnormalities. The Miami Project Male Fertility Program is a research study design…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    The Maimi Project to Cure Paralysis, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT01467869 on ClinicalTrials.gov

21. Exciflex Electroceutical Banadage for Chronic Wound Therapy

    Objectives: The study objective is to carry a pilot clinical assessment comparing the exciflex bandage to standard of care (SoC) for ischemic wounds and will involve participants who are Veterans with lower extremity ischemic wounds. Research Plan: The study will employ a randomized repeated measur…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio

    Run by

    VA Office of Research and Development

    See if you can join NCT04887688 on ClinicalTrials.gov

22. Psilocybin to Treat Depression in Spinal Cord Injury

    The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg). The main question the study aims to answer is: does psilocybin increase the number a…

    Stage

    Phase 1

    Ages

    22 and older

    Site

    James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York

    Run by

    James J. Peters Veterans Affairs Medical Center

    See if you can join NCT07251491 on ClinicalTrials.gov

23. Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)

    The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement proble…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07179822 on ClinicalTrials.gov

24. Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

    This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury).

    Stage

    Phase 4

    Ages

    18 to 89

    Site

    John D. Dingell VA Medical Center, Detroit, Michigan

    Run by

    John D. Dingell VA Medical Center

    See if you can join NCT02922894 on ClinicalTrials.gov

25. Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury

    This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI. Up to 15 participants aged 18 years or older with non-progressive SCI will be enrolled. Par…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Point West, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07674927 on ClinicalTrials.gov