Spinal Cord Injury Clinical Trials

42 studies are recruiting for spinal cord injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. CBD for Lower Urinary Tract Dysfunction in Spinal Cord Injury

   The goal of this feasibility study is to learn whether Cannabidiol (CBD) can improve urinary incontinence and other symptoms in people with recent spinal cord injury (SCI). Participants will take Epidiolex (purified CBD) for 90 days

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Wisconsin - Madison, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06840899 on ClinicalTrials.gov

2. mSCI: Mobile Health App for Veterans With SCI and Caregivers

   Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation. Military caregivers (Family Caregivers of wounded or disabled Veterans) reported simil…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT07269977 on ClinicalTrials.gov

3. Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury

   The purpose of this study is to find out whether insulin, a drug approved by the FDA for the treatment of diabetes mellitus, is safe when administered as a nasal spray (intranasally) to people who have experienced a spinal cord injury. While insulin nasal spray has been shown to be safe in many pat…

   Stage

   Phase 1

   Ages

   18 to 84

   Site

   HealthPartners Neuroscience Center, Saint Paul, Minnesota

   Run by

   HealthPartners Institute

   See if you can join NCT07384052 on ClinicalTrials.gov

4. Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury

   This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tra…

   Stage

   Not phased

   Ages

   19 to 85

   Site

   Shirley Ryan Abilitylab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT07814313 on ClinicalTrials.gov

5. Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction

   The goal of this study is to test the safety and effectiveness of Vibrant capsules in spinal cord injury patients with neurogenic bowel.

   Stage

   Not phased

   Ages

   21 and older

   Site

   TIRR Memorial Hermann, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT07213986 on ClinicalTrials.gov

6. Male Fertility Program

   Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen abnormalities. The Miami Project Male Fertility Program is a research study design…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   The Maimi Project to Cure Paralysis, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT01467869 on ClinicalTrials.gov

7. Exciflex Electroceutical Banadage for Chronic Wound Therapy

   Objectives: The study objective is to carry a pilot clinical assessment comparing the exciflex bandage to standard of care (SoC) for ischemic wounds and will involve participants who are Veterans with lower extremity ischemic wounds. Research Plan: The study will employ a randomized repeated measur…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio

   Run by

   VA Office of Research and Development

   See if you can join NCT04887688 on ClinicalTrials.gov

8. Psilocybin to Treat Depression in Spinal Cord Injury

   The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg). The main question the study aims to answer is: does psilocybin increase the number a…

   Stage

   Phase 1

   Ages

   22 and older

   Site

   James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York

   Run by

   James J. Peters Veterans Affairs Medical Center

   See if you can join NCT07251491 on ClinicalTrials.gov

9. Understanding and Enhancing Human Health and Movement

   By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclero…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

   Run by

   Louis Stokes VA Medical Center

   See if you can join NCT07738978 on ClinicalTrials.gov

10. Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)

    The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement proble…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07179822 on ClinicalTrials.gov

11. At-Home Genital Nerve Stimulation for SCI Bowel

    The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries. Current bowel treatments either involve diet and medications or surgery. This study will eva…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MetroHealth Center for Rehabilitation Research, Cleveland, Ohio

    Run by

    MetroHealth Medical Center

    See if you can join NCT06836739 on ClinicalTrials.gov

12. Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

    This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury).

    Stage

    Phase 4

    Ages

    18 to 89

    Site

    John D. Dingell VA Medical Center, Detroit, Michigan

    Run by

    John D. Dingell VA Medical Center

    See if you can join NCT02922894 on ClinicalTrials.gov

13. Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury

    This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI. Up to 15 participants aged 18 years or older with non-progressive SCI will be enrolled. Par…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Point West, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07674927 on ClinicalTrials.gov

14. Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)

    The purpose of this research study is to measure the tolerability and preliminary efficacy of a drug, galantamine, to treat metabolic syndrome (MetS) by reducing circulating inflammation in people with spinal cord injury (SCI). Galantamine is FDA-approved for the treatment of Alzheimer's disease. H…

    Stage

    Phase 2

    Ages

    21 to 75

    Site

    Northwell Health, Manhasset, New York

    Locations

    3 in total

    Run by

    Northwell Health

    See if you can join NCT07625332 on ClinicalTrials.gov

15. Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury

    To achieve our specific aims and hypotheses we will conduct a parallel group mixed methods randomized control trial comparing participation in the TEEMS program with exercise via asynchronous video library equivalent (control). The use of mixed methods will allow for the integration of quantitative…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Drexel University Health Science Building, Philadelphia, Pennsylvania

    Run by

    Drexel University

    See if you can join NCT07022808 on ClinicalTrials.gov

16. Cortical Recording and Stimulating Array Brain-Machine Interface

    The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.

    Stage

    Not phased

    Ages

    22 to 70

    Site

    University of Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    Michael Boninger

    See if you can join NCT01894802 on ClinicalTrials.gov

17. The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

    To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer tra…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Locations

    8 in total

    Run by

    AO Foundation, AO Spine

    See if you can join NCT06839300 on ClinicalTrials.gov

18. Clinical Outcome Assessment for AT & BCI

    Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers. Clinicians and researchers currently lack a common framework to objectively quantify how much a given AT or BCI improves …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT07407725 on ClinicalTrials.gov

19. Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury

    The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury. The main questions it aims to answer are: * Can site specific spinal cord stimulation enhance blood pressure regulation…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Frazier Rehabilitation Institute, Louisville, Kentucky

    Locations

    2 in total

    Run by

    University of Louisville

    See if you can join NCT07504055 on ClinicalTrials.gov

20. Neuromodulation to Improve Grasping Function After SCI

    The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    The State University of New York at Buffalo, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT07433959 on ClinicalTrials.gov

21. Virtual Peer Coaching in Manual Wheelchair Skills

    The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained. Then, trainees will be enrolled into one of three interventions: intervention with remote feedback (Group 1), and a wait list control …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT06295146 on ClinicalTrials.gov

22. MEP Up-conditioning to Target Corticospinal Plasticity

    Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation trai…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06989905 on ClinicalTrials.gov

23. Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury

    Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands. One of the consequences of SCI is spasticity - involuntary activation of muscles that can hinde…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT07501429 on ClinicalTrials.gov

24. CE-STAND: Cervical Epidural STimulation After Neurologic Damage

    CE-STAND aims to address three areas under-represented in research: chronic, cervical, and autonomic dysfunction. It is both significant and highly impactful, as treating autonomic dysfunction could substantially improve function and quality of life (QoL) in chronic cervical SCI patients.

    Stage

    Phase 1

    Ages

    22 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06410001 on ClinicalTrials.gov

25. Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis

    This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves functional arm/hand movements in individuals with paralysis or paresis due t…

    Stage

    EARLY_Phase 1

    Ages

    18 to 75

    Site

    Northwell Health's The Feinstein Institute for Medical Research, Manhasset, New York

    Run by

    Northwell Health

    See if you can join NCT04755699 on ClinicalTrials.gov