Smoking Cessation Clinical Trials

59 studies are recruiting for smoking cessation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

   The purpose of this randomized controlled trial is to assess the efficacy of Actívatexto (Aim 1) and the mediators of the presumed treatment effect (Aim 2) among Latino adults who smoke. Actívatexto is a mobile intervention that integrates four components: 1) a text messaging program that promotes …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06926608 on ClinicalTrials.gov

2. Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

   Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS a…

   Stage

   Not phased

   Ages

   22 to 65

   Site

   The University of Texas Health Science Center, Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT05276050 on ClinicalTrials.gov

3. Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

   The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products. Researchers will compare varenicline + active aTMS with a single dose of D-Clycloserine to varenicline + s…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07145866 on ClinicalTrials.gov

4. Trauma-Informed Care for Smoking Cessation for Pregnancy

   Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma, (3) Responding by embedding knowledge of trauma into practices and po…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Zuckerberg San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07129590 on ClinicalTrials.gov

5. Overcoming Nicotine Dependence to Enable Quitting

   Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers ar…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT05513872 on ClinicalTrials.gov

6. Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

   This study is a Phase 3, multicenter, randomized, double-blind, placebo- and active-controlled, parallel-group trial to evaluate the efficacy and safety of AXS-05 compared to placebo and bupropion for smoking cessation in adults.

   Stage

   Phase 3

   Ages

   18 to 65

   Site

   Clinical Research Site, Little Rock, Arkansas

   Locations

   16 in total

   Run by

   Axsome Therapeutics, Inc.

   See if you can join NCT07766655 on ClinicalTrials.gov

7. A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

   The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey

   Locations

   8 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06693700 on ClinicalTrials.gov

8. Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

   Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06678789 on ClinicalTrials.gov

9. Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

   No published studies to date have evaluated the combined impact of varenicline and oral nicotine replacement therapy (NRT) on smoking cessation in a randomized trial. Oral NRT, such as nicotine lozenges, can provide acute relief from cravings/withdrawal, and offers individuals the flexibility to de…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   TSET Health Promotion Research Center, Oklahoma City, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT07099638 on ClinicalTrials.gov

10. A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

    The purpose of this study is to provide preliminary evidence for the efficacy of 12 weeks of vagal nerve stimulation (VNS) and nicotine replacement therapy (NRT) for increasing smoking abstinence rates.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07487818 on ClinicalTrials.gov

11. Evaluating the Impact of CONNECT in a Multilingual Population

    This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities. The CONNECT program encourages individuals who are undergoing lung cancer screening to also quit sm…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07111936 on ClinicalTrials.gov

12. Family-Based Financial Incentives Intervention for Smoking Cessation

    The current study will conduct an RCT to evaluate the effectiveness of a family-based incentive intervention with Alaska Native/American Indian families. The experimental arm will be compared to a control arm on biochemically-confirmed smoking abstinence at 6- and 12-months post-intervention.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Alaska Native Tribal Health Consortium, Anchorage, Alaska

    Run by

    Mayo Clinic

    See if you can join NCT06556433 on ClinicalTrials.gov

13. Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

    The goal of this clinical trial is to compare the reach and effectiveness of the Refer2Quit intervention for increasing tobacco use treatment and quit rates among household members who smoke versus a treatment as usual group. This clinical trial also aims to study household member and pediatric pat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06582693 on ClinicalTrials.gov

14. Personalized Tobacco Treatment in Primary Care (MOTIVATE)

    This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobac…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05846841 on ClinicalTrials.gov

15. Rural Smoking Cessation

    Understanding ways to help people who live in rural areas quit smoking is a public health priority. quitting smoking among rural people who smoke is a critical public health concern. People in rural areas smoke at higher rates than those in urban areas, experience high rates of smoking caused cance…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Masonic Cancer Center, Minneapolis, Minnesota

    Run by

    Masonic Cancer Center, University of Minnesota

    See if you can join NCT06584929 on ClinicalTrials.gov

16. Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

    This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology patients and providers in the oncology care setting. The precision treatment intervention includes personalized tobacco treatment recommend…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    John Cochran Veteran's Affairs Medical Center, St Louis, Missouri

    Locations

    2 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT07166120 on ClinicalTrials.gov

17. My Path to Quit Tobacco

    The overarching goal of this program of research is to reduce smoking-related health disparities by increasing smoking cessation among Black adults. The goal of this research proposal is to determine whether more intensive, culturally specific, evidence-based interventions are more effective at pro…

    Stage

    Phase 4

    Ages

    21 and older

    Site

    UW School of Medicine and Public Health, Milwaukee, Wisconsin

    Locations

    5 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07419425 on ClinicalTrials.gov

18. Multi-Site Trial of Tirzepatide for Smoking Cessation

    This multi-site clinical trial will generate data on the efficacy of tirzepatide for smoking cessation and associated outcomes (e.g., post-cessation weight gain) in treatment-seeking people who smoke (PWS) with overweight or obesity. A sample of 300 treatment-seeking people who smoke with body mass…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    Keck School of Medicine, University of Southern California, Los Angeles, California

    Locations

    4 in total

    Run by

    University of Southern California

    See if you can join NCT07602699 on ClinicalTrials.gov

19. Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

    The investigators aim to address the following specific aims: * Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors. * Examine the effects of this maternal smoking intervention on infant health. * Examine racial and ethnic differences in…

    Stage

    Phase 4

    Ages

    18 to 45

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04783857 on ClinicalTrials.gov

20. American Indian Smokefree Native RCT

    The aim of this clinical trial is to test the efficacy of a culturally aligned digital smoking cessation resource for American Indian persons who smoke, via a remotely conducted randomized controlled trial.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Masonic Cancer Center, Minneapolis, Minnesota

    Run by

    Masonic Cancer Center, University of Minnesota

    See if you can join NCT06544811 on ClinicalTrials.gov

21. Preliminary Effectiveness of Enhanced Text Message + Incentives

    This study is a preliminary evaluation of a smoking cessation intervention designed for pregnant women that combines text message support and financial incentives. The aims of this study are to determine the preliminary feasibility and acceptability of text message + incentives (intervention) vs. t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT07420621 on ClinicalTrials.gov

22. Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

    The goal of this study is to: partner with Respiratory Health Association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke (AWS) in Chicago. This will be accomplished by establishing a communi…

    Stage

    Not phased

    Ages

    18 to 26

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06837220 on ClinicalTrials.gov

23. Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

    Using both tobacco and cannabis during pregnancy is more common in minoritized groups and can make quitting smoking in pregnancy and remaining smoke free postpartum difficult. Investigators will test an intervention to address prenatal depressive symptoms to encourage people to quit tobacco and can…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Bellefield Towers, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07489443 on ClinicalTrials.gov

24. PASCAL Feasibility Study

    The goal of this randomized study is to assess if a conversational agent (or chatbot) that the investigators have developed to help with quitting smoking is acceptable to people trying to quit smoking and to also collect initial information regarding its effectiveness. In this study, some participa…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07301151 on ClinicalTrials.gov

25. The Options 2 Study

    The goal of this clinical trial is to investigate how well nicotine pouches and nicotine mini lozenges serve as substitutes for cigarettes when people try to switch from smoking to using these alternate nicotine products. Participants will: * Use nicotine pouches, nicotine mini lozenges, or no stud…

    Stage

    Phase 4

    Ages

    21 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06595459 on ClinicalTrials.gov