Smoking Cessation Clinical Trials

60 studies are recruiting for smoking cessation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

   The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease. The normal are used to establish a set of normal ranges for various parameters. These provide control information when compared to individuals with…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT01776398 on ClinicalTrials.gov

2. Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

   This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology patients and providers in the oncology care setting. The precision treatment intervention includes personalized tobacco treatment recommend…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   John Cochran Veteran's Affairs Medical Center, St Louis, Missouri

   Locations

   2 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT07166120 on ClinicalTrials.gov

3. Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

   The goal of this project is to test if a new behavioral treatment for people who smoke nondaily and wish to quit works. The new treatment is a smartphone app that engages users in positive psychology exercises and gives them tested tools for quitting smoking. The positive psychology exercises help …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06678243 on ClinicalTrials.gov

4. Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

   This study is a Phase 3, multicenter, randomized, double-blind, placebo- and active-controlled, parallel-group trial to evaluate the efficacy and safety of AXS-05 compared to placebo and bupropion for smoking cessation in adults.

   Stage

   Phase 3

   Ages

   18 to 65

   Site

   Clinical Research Site, Little Rock, Arkansas

   Locations

   26 in total

   Run by

   Axsome Therapeutics, Inc.

   See if you can join NCT07766655 on ClinicalTrials.gov

5. Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

   Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fenway Health, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT06654414 on ClinicalTrials.gov

6. The Avenues Study: Dual Use Cessation

   The overarching goal of this research is to determine the most effective approach for helping dual users of cigarettes and electronic nicotine delivery systems (ENDS) quit smoking. 500 participants will be enrolled and can expect to be on study for 12 months.

   Stage

   Phase 4

   Ages

   21 and older

   Site

   University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06474299 on ClinicalTrials.gov

7. Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study

   Tobacco use remains the leading cause of death in the United States and contributes to more than 7 million hospitalizations annually. Being admitted to the hospital offers the perfect opportunity to support smoking cessation. Patients are motivated to quit because of their current illness and socie…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Baystate Medical Center, Springfield, Massachusetts

   Run by

   Baystate Medical Center

   See if you can join NCT05733767 on ClinicalTrials.gov

8. Quitting Matters Human Immunodeficiency Virus Hybrid Trial

   The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH). Participants will complete a 24- week (~6-month) study where the Participants will be assigned to one of two smartphone apps to help with quitting smok…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wake Forest University, Implementation Science, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT06883097 on ClinicalTrials.gov

9. Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain

   PASS2 aims to expand upon the recently completed study (PASS intervention), which tested the telephone delivery of a cognitive behavioral intervention (CBI). This study will use nightly surveys to optimize the intervention's effectiveness for smoking cessation among Veteran smokers with chronic pai…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut

   Run by

   VA Office of Research and Development

   See if you can join NCT06442514 on ClinicalTrials.gov

10. A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

    The purpose of this study is to provide preliminary evidence for the efficacy of 12 weeks of vagal nerve stimulation (VNS) and nicotine replacement therapy (NRT) for increasing smoking abstinence rates.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07487818 on ClinicalTrials.gov

11. Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

    The purpose of this randomized controlled trial is to assess the efficacy of Actívatexto (Aim 1) and the mediators of the presumed treatment effect (Aim 2) among Latino adults who smoke. Actívatexto is a mobile intervention that integrates four components: 1) a text messaging program that promotes …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT06926608 on ClinicalTrials.gov

12. Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

    Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS a…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    The University of Texas Health Science Center, Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT05276050 on ClinicalTrials.gov

13. Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

    The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products. Researchers will compare varenicline + active aTMS with a single dose of D-Clycloserine to varenicline + s…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07145866 on ClinicalTrials.gov

14. Trauma-Informed Care for Smoking Cessation for Pregnancy

    Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma, (3) Responding by embedding knowledge of trauma into practices and po…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Zuckerberg San Francisco General Hospital, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07129590 on ClinicalTrials.gov

15. Overcoming Nicotine Dependence to Enable Quitting

    Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers ar…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT05513872 on ClinicalTrials.gov

16. A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

    The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey

    Locations

    8 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06693700 on ClinicalTrials.gov

17. Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

    Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06678789 on ClinicalTrials.gov

18. Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

    No published studies to date have evaluated the combined impact of varenicline and oral nicotine replacement therapy (NRT) on smoking cessation in a randomized trial. Oral NRT, such as nicotine lozenges, can provide acute relief from cravings/withdrawal, and offers individuals the flexibility to de…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    TSET Health Promotion Research Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07099638 on ClinicalTrials.gov

19. Evaluating the Impact of CONNECT in a Multilingual Population

    This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities. The CONNECT program encourages individuals who are undergoing lung cancer screening to also quit sm…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07111936 on ClinicalTrials.gov

20. Family-Based Financial Incentives Intervention for Smoking Cessation

    The current study will conduct an RCT to evaluate the effectiveness of a family-based incentive intervention with Alaska Native/American Indian families. The experimental arm will be compared to a control arm on biochemically-confirmed smoking abstinence at 6- and 12-months post-intervention.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Alaska Native Tribal Health Consortium, Anchorage, Alaska

    Run by

    Mayo Clinic

    See if you can join NCT06556433 on ClinicalTrials.gov

21. Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

    The goal of this clinical trial is to compare the reach and effectiveness of the Refer2Quit intervention for increasing tobacco use treatment and quit rates among household members who smoke versus a treatment as usual group. This clinical trial also aims to study household member and pediatric pat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06582693 on ClinicalTrials.gov

22. Personalized Tobacco Treatment in Primary Care (MOTIVATE)

    This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobac…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05846841 on ClinicalTrials.gov

23. Rural Smoking Cessation

    Understanding ways to help people who live in rural areas quit smoking is a public health priority. quitting smoking among rural people who smoke is a critical public health concern. People in rural areas smoke at higher rates than those in urban areas, experience high rates of smoking caused cance…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Masonic Cancer Center, Minneapolis, Minnesota

    Run by

    Masonic Cancer Center, University of Minnesota

    See if you can join NCT06584929 on ClinicalTrials.gov

24. My Path to Quit Tobacco

    The overarching goal of this program of research is to reduce smoking-related health disparities by increasing smoking cessation among Black adults. The goal of this research proposal is to determine whether more intensive, culturally specific, evidence-based interventions are more effective at pro…

    Stage

    Phase 4

    Ages

    21 and older

    Site

    UW School of Medicine and Public Health, Milwaukee, Wisconsin

    Locations

    5 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07419425 on ClinicalTrials.gov

25. Multi-Site Trial of Tirzepatide for Smoking Cessation

    This multi-site clinical trial will generate data on the efficacy of tirzepatide for smoking cessation and associated outcomes (e.g., post-cessation weight gain) in treatment-seeking people who smoke (PWS) with overweight or obesity. A sample of 300 treatment-seeking people who smoke with body mass…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    Keck School of Medicine, University of Southern California, Los Angeles, California

    Locations

    4 in total

    Run by

    University of Southern California

    See if you can join NCT07602699 on ClinicalTrials.gov