Schizophrenia Clinical Trials

83 studies are recruiting for schizophrenia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Ocrelizumab for Psychosis by Autoimmunity

   Some people who have what doctors currently call schizophrenia or bipolar disease may actually have a brain disease caused by auto-antibodies. Auto-antibodies are produced when the normal defense mechanism of the body goes wrong and begins to attack the body, similar to "friendly fire." Auto-antibo…

   Stage

   Phase 1

   Ages

   18 to 35

   Site

   Houston Methodist Research Institute, Houston, Texas

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT03971487 on ClinicalTrials.gov

2. Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia

   People with schizophrenia often have problems with attention, learning and memory and other cognitive abilities that interfere with their work and school performance. Unfortunately, even our best treatments often do not significantly reduce these cognitive problems. The current study investigates w…

   Stage

   Not phased

   Ages

   18 to 47

   Site

   Imaging Research Center, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT04267003 on ClinicalTrials.gov

3. Cerebellar Stimulation and Cognitive Control

   The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Krystal Parker, PhD

   See if you can join NCT03217110 on ClinicalTrials.gov

4. Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia

   This is a double blind adjunctive randomized controlled trial for schizophrenia using cromoglicate.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Vishwajit Nimgaonkar, MD PhD

   See if you can join NCT03794076 on ClinicalTrials.gov

5. Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

   The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during d…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Center for Advanced Human Brain Imaging Research, Piscataway, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06745479 on ClinicalTrials.gov

6. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

   The Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS) study aims to understand the early stages of psychotic disorders like Schizophrenia, Schizoaffective Disorder, and Bipolar I Disorder. It involves gathering mental health information, brain scans (MRI), eye movement …

   Stage

   Not phased

   Ages

   18 to 40

   Site

   Hartford Hospital, Hartford, Connecticut

   Locations

   6 in total

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06740383 on ClinicalTrials.gov

7. NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

   The primary objective for this study is to evaluate the efficacy of NBI-1117568 compared with placebo on improving behavioral and psychological symptoms of schizophrenia in adults.

   Stage

   Phase 3

   Ages

   18 to 65

   Site

   Neurocrine Clinical Site, Bryant, Arkansas

   Locations

   21 in total

   Run by

   Neurocrine Biosciences

   See if you can join NCT06963034 on ClinicalTrials.gov

8. Enhanced Coordinated Specialty Care for Early Psychosis

   The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatm…

   Stage

   Not phased

   Ages

   Any age

   Site

   McLean Hospital OnTrack Clinic, Belmont, Massachusetts

   Locations

   5 in total

   Run by

   Mclean Hospital

   See if you can join NCT06071858 on ClinicalTrials.gov

9. Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

   Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.

   Stage

   Not phased

   Ages

   15 to 35

   Site

   Harding Hospital, Columbus, Ohio

   Run by

   Nicholas Breitborde

   See if you can join NCT04368039 on ClinicalTrials.gov

10. TMS for Inhibition Enhancement in Schizophrenia

    This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decrea…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Maryland Psychiatric Research Center, Catonsville, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06155682 on ClinicalTrials.gov

11. Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility

    The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions a…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    The University of Iowa, Iowa City, Iowa

    Run by

    Kai Hwang

    See if you can join NCT07217652 on ClinicalTrials.gov

12. CBT-CP for Veterans With SMI

    Chronic musculoskeletal pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic musculoskeletal pain leads to poorer mental and physical health-related functioning, representing a critical obstacle to rehabilitation and recovery for SMI Veterans. D…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland

    Run by

    VA Office of Research and Development

    See if you can join NCT06758414 on ClinicalTrials.gov

13. Enhancing Rehabilitation for Veterans With Serious Mental Illness

    This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chro…

    Stage

    Not phased

    Ages

    18 to 83

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06586164 on ClinicalTrials.gov

14. Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia

    This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held …

    Stage

    Not phased

    Ages

    18 to 55

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05343598 on ClinicalTrials.gov

15. Randomized Withdrawal Study in Patients With Schizophrenia

    The purpose of this research is to evaluate the efficacy of dosing iloperidone long-acting injection (LAI) compared to placebo in preventing the exacerbation of symptoms in patients with schizophrenia.

    Stage

    Phase 3

    Ages

    18 to 65

    Site

    Vanda Investigational Site, Rogers, Arkansas

    Locations

    22 in total

    Run by

    Vanda Pharmaceuticals

    See if you can join NCT06961968 on ClinicalTrials.gov

16. Taking Action for College Students

    The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses. Participants will be randomly assigned to either the experimental condition (Taking Action) or the control condition (in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Temple University, Philadelphia, Pennsylvania

    Run by

    Temple University

    See if you can join NCT06700902 on ClinicalTrials.gov

17. Study of ALTO-101 in Patients With Schizophrenia

    This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition. Additional goals are to assess pharmacokinetic (PK), safety, and tolerabil…

    Stage

    Phase 2

    Ages

    21 to 55

    Site

    Site 5038, Garden Grove, California

    Locations

    14 in total

    Run by

    Alto Neuroscience

    See if you can join NCT06502964 on ClinicalTrials.gov

18. Effectiveness of Motivation Skills Training (MST)

    This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from N=80 individuals with a Diagnostic and Statistical Manual of Mental Illnesses (DSM)-5 diagnosis of schizophrenia or schizoaffective disorder meeting inclusion/exc…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    The Bridge, Inc., New York, New York

    Locations

    2 in total

    Run by

    Columbia University

    See if you can join NCT05805397 on ClinicalTrials.gov

19. Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

    Many individuals with serious mental illness have difficulty accurately interpreting interpersonal cues and effectively engaging in social exchanges. Difficulties related to the interpersonal aspects of work can lead to isolation, poor productivity, and job loss. The goals of this study are to: 1) …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

    Run by

    VA Office of Research and Development

    See if you can join NCT05491538 on ClinicalTrials.gov

20. Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

    The purpose of this study is to evaluate the efficacy and safety of cariprazine in the treatment of schizophrenia in the adolescent population.

    Stage

    Phase 3

    Ages

    13 to 17

    Site

    Clinic of Child Psychiatry St. Nikolas, Sofia,

    Locations

    57 in total

    Run by

    Gedeon Richter Plc.

    See if you can join NCT03817502 on ClinicalTrials.gov

21. Impact of Cerebellar TMS on Brain and Cognitive Functions in Schizophrenia: a Pilot Study

    This is a single-site, sham-controlled, randomized trial in a total of 40 subjects between ages 18 and 60 years with schizophrenia. This study will investigate the effects of 4-week rTMS treatment on brain and cognitive functions in patients. Subjects will be randomized to one of the following arms…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Zucker Hillside Hospital, New York, New York

    Run by

    Northwell Health

    See if you can join NCT05389787 on ClinicalTrials.gov

22. Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

    Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Boston VA Healthcare System, Brockton, Brockton, Massachusetts

    Run by

    Boston VA Research Institute, Inc.

    See if you can join NCT05299749 on ClinicalTrials.gov

23. Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

    In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04296604 on ClinicalTrials.gov

24. Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

    This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the me…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    UCSF, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04807530 on ClinicalTrials.gov

25. iTBS to Enhance Social Cognition in People With Psychosis

    The goal of this clinical trial is to examine if iTBS applied to the DMPFC improves social cognitive performance compared to sham stimulation in people diagnosed with schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychotic disorder not otherwise specified. The main objectiv…

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Zucker Hillside Hospital, Glen Oaks, New York

    Run by

    Northwell Health

    See if you can join NCT06118268 on ClinicalTrials.gov