Rheumatoid Arthritis Clinical Trials

35 studies are recruiting for rheumatoid arthritis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

   This open-label, Phase I study will assess the safety and tolerability of surovatamig and characterise its PK and PD following subcutaneous administration to participants with RA or SLE.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Research Site, Fullerton, California

   Locations

   35 in total

   Run by

   AstraZeneca

   See if you can join NCT07201558 on ClinicalTrials.gov

2. An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

   The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis (RA) who have an inadequate response or intolerance to tumor necrosis factor (TNF) and/or Janus kinase (JAK) inhibitors, and who were previo…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   West Broward Rheumatology Associates, Inc., Tamarac, Florida

   Locations

   10 in total

   Run by

   Hoffmann-La Roche

   See if you can join NCT07620392 on ClinicalTrials.gov

3. Exactech Shoulder Post Market Clinical Follow-up Study

   The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restri…

   Stage

   Not phased

   Ages

   21 and older

   Site

   South County Orthopedic Specialists, Laguna Woods, California

   Locations

   40 in total

   Run by

   Exactech

   See if you can join NCT05603728 on ClinicalTrials.gov

4. Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

   This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California Davis Comprehensive Cancer Center, Sacramento, California

   Locations

   52 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03816345 on ClinicalTrials.gov

5. A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

   The purpose of this study is to measure the safety, tolerability, PK, and PD of AZD5492 administered subcutaneously in adult participants with SLE or IIM or RA Study details include: • The study duration will be a minimum of 180 days in addition to the screening period. Additional follow-up visits …

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Research Site, Anniston, Alabama

   Locations

   37 in total

   Run by

   AstraZeneca

   See if you can join NCT06916806 on ClinicalTrials.gov

6. A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

   Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by B cell hyperactivity. Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. The purpose of this study is to assess the pharmacokinetics, …

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Pinnacle Research Group /ID# 278677, Anniston, Alabama

   Locations

   10 in total

   Run by

   AbbVie

   See if you can join NCT07607964 on ClinicalTrials.gov

7. EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

   The purpose of this research is to gather clinical and radiographic (X-ray) information about EMPHASYS™ acetabular shell (also called a hip 'cup') placement in total hip replacement surgery using a non-invasive surgical navigation system called VELYS™ hip navigation system with CUPTIMIZE™ Advanced …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Florida Orthopaedic Institute, Gainesville, Florida

   Locations

   2 in total

   Run by

   DePuy Orthopaedics

   See if you can join NCT06631638 on ClinicalTrials.gov

8. A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

   This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   SunValley Arthritis Center Ltd., Peoria, Arizona

   Locations

   63 in total

   Run by

   Hoffmann-La Roche

   See if you can join NCT07137598 on ClinicalTrials.gov

9. Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

   Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characteriz…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05277025 on ClinicalTrials.gov

10. Phase 1b/2 Study of IV Sarilumab in Adult With RA

    This is a Phase 1/Phase 2 study with: * 5-arms design for Part A; * and a single arm for Part B. The purpose of this study is to measure PK parameters and safety with sarilumab intravenous (IV) with or without concomitant oral conventional synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Encore Medical Research - Hollywood- Site Number : 8400010, Hollywood, Florida

    Locations

    4 in total

    Run by

    Sanofi

    See if you can join NCT07704580 on ClinicalTrials.gov

11. Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

    The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), mixed connective tis…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Univeristy of Iowa, Iowa City, Iowa

    Run by

    Terry L. Wahls

    See if you can join NCT07180537 on ClinicalTrials.gov

12. A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)

    This is a Phase 1/2, open-label, multi-center, multi-cohort, non-randomized dose escalation and dose expansion basket study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with autoimmune diseases.

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Nkarta Investigational Site, Orange, California

    Locations

    18 in total

    Run by

    Nkarta, Inc.

    See if you can join NCT06733935 on ClinicalTrials.gov

13. A Study of AZD0120 in Autoimmune Diseases

    This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), or difficult-to-treat rheumatoid arth…

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Research Site, Ann Arbor, Michigan

    Locations

    22 in total

    Run by

    AstraZeneca

    See if you can join NCT07295847 on ClinicalTrials.gov

14. RA-PRO PRAGMATIC TRIAL

    The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    East Alabama Arthritis Center PC, Auburn, Alabama

    Locations

    49 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04692493 on ClinicalTrials.gov

15. A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

    Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Sun Valley Arthritis Center /ID# 278331, Peoria, Arizona

    Locations

    104 in total

    Run by

    AbbVie

    See if you can join NCT06972446 on ClinicalTrials.gov

16. Early Rheumatoid Arthritis Lung Disease Study

    Extra-articular (outside of joints) disease occurs in approximately 50% of rheumatoid arthritis (RA) patients, with the lung being a common site of involvement. The goals of this study are to investigate and characterize lung disease and its prevalence in early RA participants. This will be done th…

    Stage

    Not phased

    Ages

    19 to 90

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT03192267 on ClinicalTrials.gov

17. Ultrasound Neuroimmune Modulation in Adults With Rheumatoid Arthritis

    This two-stage, multicenter clinical trial is designed to evaluate the feasibility, safety, and preliminary efficacy of splenic ultrasound stimulation to activate immune-neuromodulation (SUSTAIN) in patients with rheumatoid arthritis (RA) and at least moderate disease activity. The findings from th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Precision Comprehensive Clinical Research Solutions, Colleyville, Texas

    Locations

    3 in total

    Run by

    Surf Therapeutics

    See if you can join NCT07293871 on ClinicalTrials.gov

18. Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

    This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown. Following completion of the …

    Stage

    Phase 1

    Ages

    18 to 70

    Site

    Mayo Clinic, Scottsdale, Arizona

    Locations

    9 in total

    Run by

    Sonoma Biotherapeutics, Inc.

    See if you can join NCT06201416 on ClinicalTrials.gov

19. A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

    Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Research Site, Willowbrook, Illinois

    Locations

    144 in total

    Run by

    AstraZeneca

    See if you can join NCT07276581 on ClinicalTrials.gov

20. Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

    Rheumatoid arthritis (RA) is a common disease with approximately 1% prevalence. RA is also a chronic, progressive disease with no cure. Current treatment goals are to minimize pain, limit joint damage, and prevent loss of function. Drugs used to treat RA include non-steroidal anti-inflammatory drug…

    Stage

    Phase 3

    Ages

    19 and older

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT03414502 on ClinicalTrials.gov

21. Imaging of Lymphatic Vessels in People With Rheumatoid Arthritis (RA)

    Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities. They established reliable and reproducible methodologies in RA patients. The purpose of this phase 2 pilot is to study RA disease progres…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT05197530 on ClinicalTrials.gov

22. Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

    This study learn how easily patients can use an educational tool that will be created for patients with melanoma and pre-existing autoimmune diseases who receive or will receive immune checkpoint inhibitor drugs. Patients will be asked their opinions about the design, accessibility, and content of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT04751396 on ClinicalTrials.gov

23. Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

    The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g…

    Stage

    Not phased

    Ages

    45 to 90

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03297775 on ClinicalTrials.gov

24. Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

    The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to support power calculations for a larger research study.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06841562 on ClinicalTrials.gov

25. Rheumatology Patient Registry and Biorepository

    To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Yale New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04402086 on ClinicalTrials.gov