Pulmonary Hypertension Clinical Trials

43 studies are recruiting for pulmonary hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Feasibility of Semaglutide in Advanced Lung Disease

   The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide …

   Stage

   Phase 1

   Ages

   18 to 80

   Site

   University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT05746039 on ClinicalTrials.gov

2. Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

   The objective of this observational pilot study is to collect HemoCept device data from subjects undergoing diagnostic right heart catheterization (RHC) procedures.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boulder Heart, Boulder, Colorado

   Run by

   HemoCept Inc.

   See if you can join NCT07224906 on ClinicalTrials.gov

3. Real World Observational Study of Sotatercept for Pulmonary Hypertension

   The purpose of this study seeks to describe the real world initial experience with sotatercept in the treatment of pulmonary hypertension.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06751082 on ClinicalTrials.gov

4. Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related Disorders

   A repository of biospecimens and detailed phenotypic information collected longitudinally from adults with congenital heart disease and related conditions, with an aim to facilitate future research on biologic mechanisms of underlying disease, compensation and deterioration; biologic correlates of …

   Stage

   Not phased

   Ages

   16 and older

   Site

   Children's Hospital Medical Center, Cincinnati, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT07477197 on ClinicalTrials.gov

5. Pulmonary Hypertension in Left Heart Disease

   The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and blood sampling.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT05935605 on ClinicalTrials.gov

6. 129 Xenon Imaging in Patients Treated With Sotatercept

   Determine the ability of 129Xe MRI/MRS biomarker signatures to non-invasively monitor pulmonary vascular reverse remodeling induced by sotatercept in pulmonary arterial hypertension (PAH).

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Bastiaan Driehuys

   See if you can join NCT06351345 on ClinicalTrials.gov

7. Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

   Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best c…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT06299436 on ClinicalTrials.gov

8. CVD/PH and Voice Characteristics

   The purpose of this study is to determine the association between patient voice signal characteristics and the presence and severity of pulmonary hypertension in patients referred for elective clinically indicated echocardiography for at Mayo Clinic MN.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07311044 on ClinicalTrials.gov

9. Pulmonary Hypertension Association Registry

   The PHA Registry (PHAR) is a national study about people who have pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). PHAR collects information from people with PAH and CTEPH who are cared for in participating PHA-accredited Pulmonary Hypertension Care C…

   Stage

   Not phased

   Ages

   0 and older

   Site

   Arizona Pulmonary Specialists, Ltd., Phoenix, Arizona

   Locations

   52 in total

   Run by

   Pulmonary Hypertension Association, Inc.

   See if you can join NCT04071327 on ClinicalTrials.gov

10. Rutgers University Study of the Genetics of Pulmonary Hypertension

    The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and reques…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rutgers University, Piscataway, New Jersey 08854, Piscataway, New Jersey

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT07217522 on ClinicalTrials.gov

11. Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

    This prospective study is a multi-center early feasibility study assessing the safety and performance of the Aria CV Pulmonary Hypertension System in patients with pulmonary hypertension and right heart dysfunction.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California-Los Angeles, Los Angeles, California

    Locations

    12 in total

    Run by

    Aria CV, Inc

    See if you can join NCT04555161 on ClinicalTrials.gov

12. Safety and Efficacy of FETO in CDH Phase III

    Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses and standard of care control group

    Stage

    Phase 3

    Ages

    18 to 50

    Site

    Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT07187206 on ClinicalTrials.gov

13. Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension

    Prospective observational study to determine if the PVD-B65 risk score for one-year mortality in patients with chronic lung disease and pulmonary hypertension (CLD-PH) can accurately risk stratify these patients and successfully predict one-year mortality from time of pulmonary hypertension diagnos…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Temple University Hospital, Philadelphia, Pennsylvania

    Run by

    Temple University

    See if you can join NCT07151768 on ClinicalTrials.gov

14. Pulmonary Hypertension Biorepository and Registry

    Establish a pulmonary hypertension registry and biorepository to lead towards a further understanding of the disease.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT04808596 on ClinicalTrials.gov

15. Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients

    Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls. PAH patients are evaluated at least every 6 months by the PAH Clinic and blood/urine samples will be…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Louisville Health, Louisville, Kentucky

    Run by

    Jiapeng Huang

    See if you can join NCT04756076 on ClinicalTrials.gov

16. Feto-Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia

    Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT02986087 on ClinicalTrials.gov

17. A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)

    Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 US live births, similar to the incidence seen within the Utah Birth Defects cohort. The diaphragmatic defect compromises lung growth and alters pulmonary vascular development. This is reflected postnatally as respiratory failur…

    Stage

    Phase 2

    Ages

    Any age

    Site

    Primary Children's Hospital, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05201144 on ClinicalTrials.gov

18. New Orleans Pulmonary Hypertension Biobank

    Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of bi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Medical Center-New Orleans, New Orleans, Louisiana

    Run by

    Louisiana State University Health Sciences Center in New Orleans

    See if you can join NCT03269630 on ClinicalTrials.gov