Pulmonary Hypertension Clinical Trials

43 studies are recruiting for pulmonary hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

   Background: - High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause. Researchers want to follow the natural history of all PAH patients to understand how PAH progresses in…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institutes of Health Clinical Center (CC)

   See if you can join NCT01730092 on ClinicalTrials.gov

2. A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

   A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Clinical Research Site, Kissimmee, Florida

   Locations

   3 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07816185 on ClinicalTrials.gov

3. Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

   MOMENTOUS is a multi-center, randomized study to prospectively evaluate the performance of an ECG-based AI device to predict whether participants with interstitial lung disease (ILD) are at high risk of undiagnosed pulmonary hypertension.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   37 in total

   Run by

   Tempus AI

   See if you can join NCT06911632 on ClinicalTrials.gov

4. A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

   This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Clinical Research Site, Santa Barbara, California

   Locations

   13 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07333183 on ClinicalTrials.gov

5. Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

   Patients with pulmonary arterial hypertension (PAH) are at increased risk of muscle loss and decreased physical activity. This study will aim to (1) understand the way in which muscle loss occurs in PAH, particularly the role of fat surrounding the heart, and (2) look at the impact muscle loss has …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pennsylvania Hospital, Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pennsylvania

   See if you can join NCT07132788 on ClinicalTrials.gov

6. Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

   Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their ability to select the most …

   Stage

   Not phased

   Ages

   0 to 0

   Site

   The University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   2 in total

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06373289 on ClinicalTrials.gov

7. DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

   This is a prospective, real world, multicenter, registry of patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD) and interstitial lung disease (ILD).

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   71 in total

   Run by

   United Therapeutics

   See if you can join NCT06388421 on ClinicalTrials.gov

8. Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope

   The major goal of the study is to determine whether phonocardiography (using the Eko DUO stethoscope which can capture a three lead ECG reading) can present features that relate to the presence of PH diagnosed by echocardiography or right heart catheterization (RHC), and therefore have a potential …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Providence VA Medical Center, Providence, Rhode Island

   Locations

   3 in total

   Run by

   Eko Devices, Inc.

   See if you can join NCT05873387 on ClinicalTrials.gov

9. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

   The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Banner - University Medical Center Tucson, Tucson, Arizona

   Locations

   6 in total

   Run by

   Pulnovo Medical, Inc.

   See if you can join NCT07214376 on ClinicalTrials.gov

10. HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

    Study of HS235 in Obese Participants with Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Investigational Site-101, Greenville, South Carolina

    Run by

    35Pharma Inc

    See if you can join NCT07123779 on ClinicalTrials.gov

11. Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

    The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect.

    Stage

    Phase 2

    Ages

    8 to 60

    Site

    Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

    Locations

    3 in total

    Run by

    Paul Szabolcs

    See if you can join NCT03630211 on ClinicalTrials.gov

12. Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

    The primary objective of this study is to evaluate the effect of 24-weeks of once daily treatment with TPIP versus placebo on exercise capacity in adults with PH-ILD.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    USA001, Santa Barbara, California

    Locations

    145 in total

    Run by

    Insmed Incorporated

    See if you can join NCT07179380 on ClinicalTrials.gov

13. An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

    The primary objective of this study is to evaluate the safety and tolerability of the long-term use of TPIP in participants with PH-ILD from Study INS1009-311 (NCT07179380).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    USA006, Naples, Florida

    Locations

    9 in total

    Run by

    Insmed Incorporated

    See if you can join NCT07234032 on ClinicalTrials.gov

14. Xenon MRI Pulm Hypertension

    The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with 129Xe MRI/MRS) and how these signals change with disease progression or t…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Bastiaan Driehuys

    See if you can join NCT04991454 on ClinicalTrials.gov

15. Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

    The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-RVF) patients to lung transplant safely.

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT06770023 on ClinicalTrials.gov

16. The Benefits of Home Exercise in Pulmonary Hypertension Interstitial Lung Disease

    This study evaluates the effects of a structured home exercise program in participants with pulmonary hypertension associated with interstitial lung disease. Participants will complete a defined exercise regimen over a 16-week period, and functional capacity and patient reported outcomes will be as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07561034 on ClinicalTrials.gov

17. Bioenergetic Effect of Pioglitazone in CLD-PH

    The goal of this clinical trial is to learn about the safety and efficacy of Pioglitazone in people with Pulmonary Hypertension (PH) due to Chronic Lung Disease (CLD). The main question it aims to answer is: • Whether pioglitazone affects mitochondrial oxygen utilization in patients with PH due to …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Emory Healthcare System, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06336798 on ClinicalTrials.gov

18. An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

    Study LTI-401 is an open-label, multicenter study which will evaluate the safety and tolerability of LIQ861 in subjects who have WHO Group 1 \& 3 PH.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Arizona Pulmonary Specialists, Phoenix, Arizona

    Locations

    23 in total

    Run by

    Liquidia Technologies, Inc.

    See if you can join NCT06129240 on ClinicalTrials.gov

19. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner-University Medical Center Phoenix, Phoenix, Arizona

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

20. Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

    The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, e…

    Stage

    Phase 2

    Ages

    35 to 89

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Locations

    5 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05937854 on ClinicalTrials.gov

21. Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease

    This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns …

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05896579 on ClinicalTrials.gov

22. Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease

    This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patt…

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07576894 on ClinicalTrials.gov

23. Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

    The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

    Stage

    Phase 1

    Ages

    3 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    Mario Castro, MD, MPH

    See if you can join NCT04624490 on ClinicalTrials.gov

24. Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension

    Pulmonary hypertension (PH) is a serious condition that puts strain on the heart and lungs and often leads to frequent hospital stays and shortened life expectancy. The most common cause is heart disease affecting the left side of the heart. A particularly high-risk form, called combined pre- and p…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT07563322 on ClinicalTrials.gov

25. iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

    Children with pulmonary hypertension (PH) engage in less physical activity than their peers. This is a concern since adult data support exercise as a non-pharmacologic treatment for PH. Despite adult data, therapeutic exercise has not been widely adopted in pediatric PH. Investigators have previous…

    Stage

    Not phased

    Ages

    8 to 18

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT05442671 on ClinicalTrials.gov