Prostate Cancer Clinical Trials

287 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. A Single-arm, Multicenter Prospective Study to Evaluate the Diagnostic Performance of PROSTest in Men With PSA ≥ 3ng/ml Using Biopsy as the Sole Ground Truth

   This prospective observational study will enroll men referred for prostate biopsy due to elevated PSA and/or abnormal digital rectal examination, with or without pre-biopsy MRI. Peripheral blood will be collected prior to biopsy for PROSTest analysis. Biopsy histopathology will serve as the referen…

   Stage

   Not phased

   Ages

   45 to 80

   Site

   Wren Laboratories, Branford, Connecticut

   Run by

   Wren Laboratories LLC

   See if you can join NCT07454603 on ClinicalTrials.gov

2. A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

   This is a dose-finding study to assess the safety and preliminary antitumor activity of Pocenbrodib alone or with darolutamide in patients with metastatic castration-resistant prostate cancer (mCRPC)

   Stage

   Phase 1

   Ages

   18 and older

   Site

   MemorialCare Orange Coast Medical Center, Fountain Valley, California

   Locations

   19 in total

   Run by

   Pathos AI, Inc.

   See if you can join NCT06785636 on ClinicalTrials.gov

3. Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial

   The purpose of this study is to assess the best time to deliver a message to increase physical activity and how often participants will experience a pain episode in the 24 hours following their receipt of a message to increase physical activity.

   Stage

   Not phased

   Ages

   65 and older

   Site

   Froedtert Hospital, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT07227077 on ClinicalTrials.gov

4. MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer

   The goal of this clinical trial is to determine the safety of stereotactic body radiation therapy (SBRT) microboost technique in patients with low to intermediate risk prostate cancer. The main question it aims to answer is: Is microboost SBRT with whole gland de-escalation both safe and effective …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT07644598 on ClinicalTrials.gov

5. Impact of an Electronic Health Record Maintenance Alert on PSA Screening Rates in a 10-Hospital Integrated Health System

   - The investigators propose a clinical trial to evaluate the impact of annual shared decision making for PSA screening, supported by system-level enhancements to promote evidence-based care: * Defined referral thresholds within the health maintenance reminder, aligned with clinical risk stratificat…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07109427 on ClinicalTrials.gov

6. AI Algorithm-Informed Biopsy for Prostate Cancer Detection With Indeterminate and Low-Risk Prostate MRI Lesions

   Use of AI algorithm for PCa detection is feasible, and AI-informed biopsies (AI-targeted and perilesional biopsy) improves csPCa detection in patients with indeterminate MRI lesions and in patients with low-risk MRI lesions and high-risk clinical features.

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Arkansas for Medical Sciences, Little Rock, Arkansas

   Run by

   University of Arkansas

   See if you can join NCT07231627 on ClinicalTrials.gov

7. Water Vapor Ablation for Prostate Cancer: Long-Term Registry

   The purpose of the registry is to evaluate real-world safety, efficacy, and patient reported outcomes among participants receiving Vanquish Water Vapor Ablation System therapy (Vanquish Therapy). This includes longitudinal assessment of patients who have received or will receive the therapy one or …

   Stage

   Not phased

   Ages

   Any age

   Site

   WK Advanced Urology Specialists, Bossier City, Louisiana

   Locations

   4 in total

   Run by

   Francis Medical Inc.

   See if you can join NCT07455058 on ClinicalTrials.gov

8. Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone Therapy

   This study is evaluating whether acupuncture may help reduce hot flashes in men receiving hormone therapy for prostate cancer. Hot flashes are a common side effect of androgen deprivation therapy (ADT) and may negatively affect sleep, mood, concentration, daily activities, and overall quality of li…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   University of Kentucky

   See if you can join NCT07594002 on ClinicalTrials.gov

9. EDRN Prostate MRI Biomarker Study

   The commercialization of MRI fusion biopsies has resulted in a dramatic increase in the use of MRI imaging for prostate cancer. How best to use MRI in the initial prostate biopsy setting given the availability of validated prostate cancer early detection markers is uncertain.This study will allow i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT03784924 on ClinicalTrials.gov

10. Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

    The goal of this clinical trial is to learn if fezolinetant can treat hot flashes (vasomotor symptoms) in men with prostate cancer undergoing androgen deprivation therapy. The main questions it aims to answer are: * Does fezolinetant improve the frequency and severity of hot flashes? * Does fezolin…

    Stage

    Phase 2

    Ages

    40 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Shehzad Basaria, M.D.

    See if you can join NCT06957691 on ClinicalTrials.gov

11. Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

    The objective of this study is to see if providing an appropriate therapy based on the genomic testing of prostate tumour tissue will result in an improved clinical response. Each participant will be treated with 8 weeks of a luteinizing hormone-releasing hormone agonist (LHRHa) plus apalutamide (A…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California Davis, Sacramento, California

    Locations

    9 in total

    Run by

    University of British Columbia

    See if you can join NCT04812366 on ClinicalTrials.gov

12. Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)

    Multiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary biopsies and reduce the incidence of over-diagnosis of non-csPCa. Furt…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Texas MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05043012 on ClinicalTrials.gov

13. A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

    A single-center phase Ib/II dose escalation and dose-expansion clinical trial of REGN5678 plus cemiplimab

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The University of Texas M. D. Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06826768 on ClinicalTrials.gov

14. NLP-Based Feedback to Improve Risk Comms and Informed Shared Decision Making

    In this pilot study, the investigators will show feasibility of the NLP-based feedback system in 20 consultations of men with newly diagnosed prostate cancer. The investigators will recruit from the practices of up to 10 physicians who typically see these patients. The investigators will report the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT05923684 on ClinicalTrials.gov

15. Comprehensive Monitoring of Men With Prostate Cancer Cared for by "Active Surveillance

    Prostate cancer is the most commonly diagnosed cancer in men. However, there is a wide range in prognosis determined by a host of factors. This study will evaluate the feasibility of guiding therapeutic intervention electronically facilitated symptom and disease monitoring in patients being followe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05840484 on ClinicalTrials.gov

16. Prospective Database of Clinical Outcomes Following Cryotherapy for Ablation of Clinically Localized Prostate Cancer

    This will be a prospectively maintained research database. The purpose is to record baseline parameters and treatment outcomes following of Cryotherapy for ablation of clinically localized prostate cancer.

    Stage

    Not phased

    Ages

    40 to 85

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07184957 on ClinicalTrials.gov

17. Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

    This study aims to compare the novel single-port robotic partial prostatectomy to High-intensity focused ultrasound (HIFU) in patients with low to intermediate risk localized prostate cancer. These interventions have become acceptable focal therapies prevalent with beneficial oncologic outcomes and…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Case Comprehensive Cancer Center, Cleveland, Ohio

    Run by

    Case Comprehensive Cancer Center

    See if you can join NCT05610852 on ClinicalTrials.gov

18. Comparison of New SUREcore Biopsy of Needle to Standard of Care During Transperineal Prostate Biopsies

    To study a novel biopsy needle system for performing transperineal prostate biopsy. Prostate biopsy remains the standard approach for prostate cancer detection. While pre-biopsy MRI allows for targeting of visible lesions, systemic or 'off target' samples are recommended due to the well-recognized …

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Departments of Urologic Oncology, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT06907446 on ClinicalTrials.gov

19. Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT

    The purpose of this research study is to test the efficacy of ADT on prostate-specific membrane antigen (PSMA), a marker of prostate cancer, before and after scheduled ADT. Follow up will be 48 months your prostate removal to do a blood test and log if any new or worsening symptoms have occurred as…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Miami Cancer Institute at Baptist Health, Inc., Miami, Florida

    Run by

    Baptist Health South Florida

    See if you can join NCT07455903 on ClinicalTrials.gov

20. IDOV-Immune for Advanced Solid Tumors

    This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cells and have the potent…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Locations

    5 in total

    Run by

    ViroMissile, Inc.

    See if you can join NCT06910657 on ClinicalTrials.gov

21. A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer

    The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    2 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07225309 on ClinicalTrials.gov

22. Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

    The primary objectives of this study are to evaluate the safety and tolerability of xaluritamig administered as monotherapy or in combination with an oral Gonadotropin-releasing Hormone (GnRH) antagonist in the neoadjuvant setting followed by radical prostatectomy, and to evaluate the feasibility a…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California San Francisco, San Francisco, California

    Locations

    9 in total

    Run by

    Amgen

    See if you can join NCT06613100 on ClinicalTrials.gov

23. RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

    This study is testing the way that approved androgen deprivation therapy treatments, Leuprolide and Relugolix, for prostate cancer affect quality of life, blood levels, cholesterol, and blood sugar. The drugs are already standard treatment for people with prostate cancer, and the drugs will be used…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Dana-Farber Cancer Institute, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT05765500 on ClinicalTrials.gov

24. Clinical Outcomes in Prostate Cancer Patients Undergoing HIFU Ablation

    Many reports of clinical outcomes following treatment of localized prostate cancer suffer from lack of prospective long-term data using objective and validated outcome instruments. The purpose of this research database is to prospectively collect data to assess treatment related complications, onco…

    Stage

    Not phased

    Ages

    40 to 95

    Site

    NYU Langone Health - Cobble Hill, Brooklyn, New York

    Locations

    2 in total

    Run by

    NYU Langone Health

    See if you can join NCT07203482 on ClinicalTrials.gov

25. Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

    The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer and are undergoing androgen deprivation therapy (ADT), and whether it w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT05327465 on ClinicalTrials.gov