PreDiabetes Clinical Trials

53 studies are recruiting for prediabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

   Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The propose…

   Stage

   Not phased

   Ages

   25 to 65

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06424106 on ClinicalTrials.gov

2. Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being

   The goal of this pilot clinical trial is to learn if a community referral program can improve services for youth with mental health and chronic health conditions in a predominantly Native Hawaiian and Pacific Islander community. The main questions the trial aims to address are: * What is the best w…

   Stage

   Not phased

   Ages

   12 to 25

   Site

   Waianae Coast Comprehensive Health Center, Waianae, Hawaii

   Run by

   Waianae Coast Comprehensive Health Center

   See if you can join NCT07536256 on ClinicalTrials.gov

3. Dinner Time for Obesity and Prediabetes

   Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by whic…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Johns Hopkins Bayview Medical Center, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05745441 on ClinicalTrials.gov

4. Continuous Glucose Monitoring (CGM) in Prediabetes With Community Based Recruitment

   The objective of this project is to develop a behavioral intervention that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and educational video clips generated by artificial intelligence (AI) software to improve glycemic control among individuals with pre-diabetes. T…

   Stage

   Not phased

   Ages

   35 and older

   Site

   Southern California Center for Latino Health (SCCLH), Los Angeles, California

   Run by

   David S Black, PhD

   See if you can join NCT07477249 on ClinicalTrials.gov

5. Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

   This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss, cardiovascular risk reduction, and renal protecti…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   UTHealth Clinical Research Unit (CRU) at UT Brownsville, Brownsville, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT05119179 on ClinicalTrials.gov

6. Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes

   Adapt the Regulation of Cues (ROC) treatment program for Latinas to see if it can treat prediabetes and prevent developing of Type 2 Diabetes and reduce weight.

   Stage

   Not phased

   Ages

   18 to 55

   Site

   UCSD Center for Healthy Eating and Activity Research (CHEAR, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT07478263 on ClinicalTrials.gov

7. Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes

   This study will address the following aims: Aim 1 (primary): Conduct a pilot RCT to evaluate the feasibility, acceptability, enrollment, and retention rates of adult-child pairs after a 12-week family-centered, non-calorie restricted whole foods diet. Feasibility: ≥80% participant retention and com…

   Stage

   Not phased

   Ages

   6 to 59

   Site

   Vanderbilt University School of Nursing, Nashville, Tennessee

   Run by

   Vanderbilt University

   See if you can join NCT06482944 on ClinicalTrials.gov

8. Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans

   This nested pilot Randomized Clinical Trial will determine whether the Diabetes Prevention Program (DPP) enhanced with evidence-based sleep health and time restricted eating interventions ("DPP++") is more effective than the DPP alone for improving metabolic and cardiovascular metrics in 40 overwei…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Nutrition Clinic, University of Delaware, Newark, Delaware

   Run by

   University of Delaware

   See if you can join NCT07450118 on ClinicalTrials.gov

9. Rural Alliance for Diabetes Prevention

   The purpose of this randomized controlled trial is to compare the effectiveness of Cooperative Extension implementing two delivery methods (group video vs. self-directed) and participant recruitment strategies of the National Diabetes Prevention Program (NDPP) to adults in rural communities. Explor…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06252038 on ClinicalTrials.gov

10. WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time

    The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact that evening screen time may have on your health.

    Stage

    Not phased

    Ages

    26 and older

    Site

    Arizona State University, Tempe, Arizona

    Run by

    Arizona State University

    See if you can join NCT06963736 on ClinicalTrials.gov

11. Blood Markers of Early Pancreas Cancer

    Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an individual's chance of surviving the disease. The investigators propose…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Unversity of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT03568630 on ClinicalTrials.gov

12. Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes

    Objectives: This study aims to test whether a mobile app called PortionSize Ed can help adults who have had a recent stroke and also have prediabetes or type 2 diabetes improve their diet. Specifically, we want to see if the app can help people follow a Mediterranean-style diet, which may lower the…

    Stage

    Not phased

    Ages

    30 to 65

    Site

    University of Hawaii Cancer Center, Honolulu, Hawaii

    Run by

    University of Hawaii

    See if you can join NCT07120334 on ClinicalTrials.gov

13. Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center

    The purpose of the study is to assess the feasibility and acceptability of incorporating hands-on nutritional demonstrations to enhance the Diabetes Prevention Program (DPP) curriculum among patients who are at-risk for prediabetes

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06897982 on ClinicalTrials.gov

14. Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

    This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in people with obesity/overweight and diabetes/pre-diabetes who have a low income.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05799222 on ClinicalTrials.gov

15. The Role of Islet GLP-1 in the Pathogenesis of Prediabetes

    We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression of PC-1/3 and GL…

    Stage

    Phase 2

    Ages

    25 to 70

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06967558 on ClinicalTrials.gov

16. Post Prandial Individual Responses to Different Foods

    This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06989164 on ClinicalTrials.gov

17. How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes

    The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from differen…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Nevada Las Vegas, Las Vegas, Nevada

    Locations

    2 in total

    Run by

    University of Nevada, Las Vegas

    See if you can join NCT06817252 on ClinicalTrials.gov

18. New T-UP: Engaging Vulnerable Students in Diabetes Prevention

    The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tail…

    Stage

    Not phased

    Ages

    17 to 25

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT07225218 on ClinicalTrials.gov

19. Effects of Dihydroberberine (DHB) on GLP-1, Glycemic Control, Appetite, and Mood in Adults With Pre-Diabetes

    The goal of this clinical trial is to learn if Dihydroberberine (DHB) supplementation affects adults with pre-diabetes. The main questions it aims to answer are: Does DHB supplementation increase the concentration of GLP-1 in the blood? Does DHB supplementation affect appetite, mood, and energy lev…

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Merieux NutriSciences, Addison, Illinois

    Run by

    Nanjing Nutrabuilding Bio-tech Co., Ltd.

    See if you can join NCT07210684 on ClinicalTrials.gov

20. Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

    Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8 (LE8; LS7+sleep) metrics, is a major contributor to Black men having …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06055036 on ClinicalTrials.gov

21. Insulin and Insulin Pulses During Fasting

    Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The propose…

    Stage

    Not phased

    Ages

    25 to 65

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06424015 on ClinicalTrials.gov

22. Fresh Takes!: An Evaluation of the Impact of Receiving Fresh Food Boxes

    Fresh Takes! is a targeted food distribution and nutrition education program offered by Montefiore Bronx Health Collective, a Federally Qualified Health Center located in the South Bronx. The goal of Fresh Takes! is to help reduce food insecurity and prevent progressions to overt diabetes in patien…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Montefiore Bronx Health Collective, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT06019624 on ClinicalTrials.gov

23. Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.

    DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, current heal…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Clindove Research LLC, Brooklyn, New York

    Run by

    Clindove Research LLC

    See if you can join NCT07106879 on ClinicalTrials.gov

24. Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics

    The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs. a multifaceted technology-assisted health coach implementation strategy (12 in-perso…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT06116149 on ClinicalTrials.gov

25. Social Determinants and a Diabetes Prevention Program Tailored for African Americans

    African Americans (AAs) have rates of diabetes mellitus (DM) twice that of Whites and are disproportionately affected by leading risk factors for DM - obesity and low-income. A critical strategy in the battle against DM is the Diabetes Prevention Program (DPP), an evidence-based intervention that s…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Missouri-Kansas City, Kansas City, Missouri

    Locations

    2 in total

    Run by

    University of Missouri, Kansas City

    See if you can join NCT05301413 on ClinicalTrials.gov