Prediabetes Clinical Trials

51 studies are recruiting for prediabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes

   This study will address the following aims: Aim 1 (primary): Conduct a pilot RCT to evaluate the feasibility, acceptability, enrollment, and retention rates of adult-offspring pairs or adult-spouse/significant other pairs after a 12-week family-centered, non-calorie restricted whole foods diet. Aim…

   Stage

   Not phased

   Ages

   6 to 59

   Site

   Vanderbilt University School of Nursing, Nashville, Tennessee

   Run by

   Vanderbilt University

   See if you can join NCT06482944 on ClinicalTrials.gov

2. New T-UP: Engaging Vulnerable Students in Diabetes Prevention

   The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tail…

   Stage

   Not phased

   Ages

   17 to 25

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07225218 on ClinicalTrials.gov

3. SMART GOALS for Youth With Prediabetes

   The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical activity frequency in obese children with prediabetes in the outpatient…

   Stage

   Not phased

   Ages

   10 to 18

   Site

   Northwell Health, New York, New York

   Locations

   2 in total

   Run by

   Northwell Health

   See if you can join NCT06067451 on ClinicalTrials.gov

4. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

   This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

   Stage

   Not phased

   Ages

   14 to 18

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06007404 on ClinicalTrials.gov

5. Insulin and Insulin Pulses During Fasting

   Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The propose…

   Stage

   Not phased

   Ages

   25 to 65

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06424015 on ClinicalTrials.gov

6. How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes

   The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from differen…

   Stage

   Not phased

   Ages

   45 to 80

   Site

   University of Nevada Las Vegas, Las Vegas, Nevada

   Locations

   2 in total

   Run by

   University of Nevada, Las Vegas

   See if you can join NCT06817252 on ClinicalTrials.gov

7. Pharmacist-Led Continuous Glucose Monitoring for Prediabetes

   The goal of this observational study is to determine if a pharmacist-led program involving continuous glucose monitoring (CGM) improves glucose control and health behavior in people with prediabetes. The main questions it aims to answer are: 1. Determine impact of pharmacist-led CGM on glycemic con…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   USF Health Department of Family Medicine - Morsani Center for Advanced Health Care, Tampa, Florida

   Locations

   2 in total

   Run by

   University of South Florida

   See if you can join NCT07529366 on ClinicalTrials.gov

8. Mediterranean Diet and Blood Sugar Study

   The purpose of this research study is to determine if a healthy Mediterranean diet containing one medium potato/day has equivalent or non-different effects on risk factors for type 2 diabetes and heart disease compared to a healthy Mediterranean diet without potatoes in adults with prediabetes. Par…

   Stage

   Not phased

   Ages

   25 to 65

   Site

   The Pennsylvania State University, University Park, Pennsylvania

   Run by

   Penn State University

   See if you can join NCT07229781 on ClinicalTrials.gov

9. Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes

   This study will examine whether very short bouts of stair climbing performed throughout the day can improve blood sugar control and cardiovascular health in adults with prediabetes. Participants will complete three separate study visits in random order: uninterrupted sitting, sitting interrupted by…

   Stage

   Not phased

   Ages

   18 to 69

   Site

   Saint Louis University, St Louis, Missouri

   Run by

   St. Louis University

   See if you can join NCT07847684 on ClinicalTrials.gov

10. A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

    TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease …

    Stage

    Not phased

    Ages

    55 and older

    Site

    Chandler Clinical Trials, Chandler, Arizona

    Locations

    125 in total

    Run by

    Cleerly, Inc.

    See if you can join NCT06112418 on ClinicalTrials.gov

11. Georgia CEAL RESTORES Family Diabetes Study

    The goal of this clinical trial is to determine whether a family-based lifestyle intervention reduces the risk of type 2 diabetes (T2D) among parents and their children. The intervention will also evaluate how well the program supports healthy lifestyle behaviors and family engagement. The primary …

    Stage

    Not phased

    Ages

    12 and older

    Site

    Morehouse School of Medicine, Atlanta, Georgia

    Run by

    Morehouse School of Medicine

    See if you can join NCT07808723 on ClinicalTrials.gov

12. Integrating a Prescription Produce Program Within a Diabetes Prevention Program

    Type 2 Diabetes remains a major chronic disease among adults in the United States. A way to prevent Type 2 Diabetes is to engage in a diabetes prevention program. In the diabetes prevention program, individuals at risk of Type 2 Diabetes meet with a health coach to learn effective ways to build hea…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Virginia Commonwealth University, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT07472712 on ClinicalTrials.gov

13. This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder

    The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body composition, and cardiometabolic health. The main questions it aims to ans…

    Stage

    Not phased

    Ages

    6 to 18

    Site

    UVA Health, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT07804680 on ClinicalTrials.gov

14. Ketogenic Diet and Diabetes Demonstration Project

    KDDP is a prospective, 12-month pilot study comparing the effects of a novel lifestyle program, the Ketogenic Diet and Diabetes Demonstration Project (KDDP) to those of the National Diabetes Prevention Program (NDDP). KDDP is modeled to mimic the delivery platform of NDPP with the exception that pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT06115265 on ClinicalTrials.gov

15. Peanuts for Cardiometabolic, Brain, and Intestinal Health

    The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.

    Stage

    Not phased

    Ages

    20 to 59

    Site

    Georgia State University, Atlanta, Georgia

    Run by

    Georgia State University

    See if you can join NCT06867198 on ClinicalTrials.gov

16. Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes

    The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes. The main questions it aims to answer are: * Does a shared-decision making visit with a health care team member to talk about the participant…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Johns Hopkins Community Physicians Frederick, Frederick, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07553325 on ClinicalTrials.gov

17. Vitamin D and Type 2 Diabetes - Treat-To-Target

    This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels in adults at high risk of developing type 2 diabetes (prediabetes). Research suggests that vitamin D may play a role in blood sugar control…

    Stage

    Phase 3

    Ages

    30 to 74

    Site

    Tufts Medical Center, Boston, Massachusetts

    Run by

    Tufts Medical Center

    See if you can join NCT07448974 on ClinicalTrials.gov

18. Human Immunodeficiency Virus (HIV) Food Insecurities

    The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed to reduce these comorbidities among food insecure PWH. The PI and staff…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Wake Forest Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04943861 on ClinicalTrials.gov

19. Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

    This pilot study aims to explore the potential benefits of consuming Greek bottarga (grey mullet fish roe) in individuals with at least one metabolic abnormality (low HDL cholesterol, high LDL cholesterol, high triglycerides, obesity, or HbA1c ≥ 5.7%) or a diagnosis of diabetes. Before initiating t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Cambridge Health Alliance, Sommerville, Massachusetts

    Run by

    Cambridge Health Alliance

    See if you can join NCT06988462 on ClinicalTrials.gov

20. Study EHR Risk Stratification Tools

    This study evaluates whether adding machine learning-based risk information to electronic health record (EHR) lab result messages helps older adults better understand their risk of developing diabetes and influences their emotional responses, quality of life, and healthcare use. Eligible participan…

    Stage

    Not phased

    Ages

    65 and older

    Site

    UCLA Health System, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06995378 on ClinicalTrials.gov

21. Mechanisms for Activation of Beige Adipose Tissue in Humans

    Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients

    Stage

    Phase 2

    Ages

    35 to 65

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Philip Kern

    See if you can join NCT04666636 on ClinicalTrials.gov

22. Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

    Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with normal blood sugar levels. The study will also test whether a single dose o…

    Stage

    Not phased

    Ages

    60 to 75

    Site

    UAB Comprehensive Cancer Center, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07546409 on ClinicalTrials.gov

23. Food and Metabolism Study

    In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.

    Stage

    Not phased

    Ages

    40 to 70

    Site

    Clinical Nutrition Research Center at IIT, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT07624500 on ClinicalTrials.gov

24. Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial

    The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs. urban/suburban nature areas/preserves) in adults with prediabetes. The main questions it …

    Stage

    Not phased

    Ages

    25 to 64

    Site

    Lake Forest Hospital, Lake Forest, Illinois

    Locations

    3 in total

    Run by

    University of Minnesota

    See if you can join NCT06365723 on ClinicalTrials.gov

25. Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

    We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

    Stage

    Not phased

    Ages

    40 to 65

    Site

    University of Arkansas for Medical Sciences, Little Rock, Arkansas

    Run by

    University of Arkansas

    See if you can join NCT06025292 on ClinicalTrials.gov