PreDiabetes Clinical Trials

53 studies are recruiting for prediabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Georgia CEAL RESTORES Family Diabetes Study

   The goal of this clinical trial is to determine whether a family-based lifestyle intervention reduces the risk of type 2 diabetes (T2D) among parents and their children. The intervention will also evaluate how well the program supports healthy lifestyle behaviors and family engagement. The primary …

   Stage

   Not phased

   Ages

   12 and older

   Site

   Morehouse School of Medicine, Atlanta, Georgia

   Run by

   Morehouse School of Medicine

   See if you can join NCT07808723 on ClinicalTrials.gov

2. Integrating a Prescription Produce Program Within a Diabetes Prevention Program

   Type 2 Diabetes remains a major chronic disease among adults in the United States. A way to prevent Type 2 Diabetes is to engage in a diabetes prevention program. In the diabetes prevention program, individuals at risk of Type 2 Diabetes meet with a health coach to learn effective ways to build hea…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Virginia Commonwealth University, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT07472712 on ClinicalTrials.gov

3. This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder

   The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body composition, and cardiometabolic health. The main questions it aims to ans…

   Stage

   Not phased

   Ages

   6 to 18

   Site

   UVA Health, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT07804680 on ClinicalTrials.gov

4. Ketogenic Diet and Diabetes Demonstration Project

   KDDP is a prospective, 12-month pilot study comparing the effects of a novel lifestyle program, the Ketogenic Diet and Diabetes Demonstration Project (KDDP) to those of the National Diabetes Prevention Program (NDDP). KDDP is modeled to mimic the delivery platform of NDPP with the exception that pa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of New Mexico, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT06115265 on ClinicalTrials.gov

5. Peanuts for Cardiometabolic, Brain, and Intestinal Health

   The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.

   Stage

   Not phased

   Ages

   20 to 59

   Site

   Georgia State University, Atlanta, Georgia

   Run by

   Georgia State University

   See if you can join NCT06867198 on ClinicalTrials.gov

6. Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes

   The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes. The main questions it aims to answer are: * Does a shared-decision making visit with a health care team member to talk about the participant…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Johns Hopkins Community Physicians Frederick, Frederick, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07553325 on ClinicalTrials.gov

7. A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

   TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease …

   Stage

   Not phased

   Ages

   55 and older

   Site

   Chandler Clinical Trials, Chandler, Arizona

   Locations

   125 in total

   Run by

   Cleerly, Inc.

   See if you can join NCT06112418 on ClinicalTrials.gov

8. Vitamin D and Type 2 Diabetes - Treat-To-Target

   This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels in adults at high risk of developing type 2 diabetes (prediabetes). Research suggests that vitamin D may play a role in blood sugar control…

   Stage

   Phase 3

   Ages

   30 to 74

   Site

   Tufts Medical Center, Boston, Massachusetts

   Run by

   Tufts Medical Center

   See if you can join NCT07448974 on ClinicalTrials.gov

9. Pharmacist-Led Continuous Glucose Monitoring for Prediabetes

   The goal of this observational study is to determine if a pharmacist-led program involving continuous glucose monitoring (CGM) improves glucose control and health behavior in people with prediabetes. The main questions it aims to answer are: 1. Determine impact of pharmacist-led CGM on glycemic con…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   USF Health Department of Family Medicine - Morsani Center for Advanced Health Care, Tampa, Florida

   Locations

   2 in total

   Run by

   University of South Florida

   See if you can join NCT07529366 on ClinicalTrials.gov

10. Human Immunodeficiency Virus (HIV) Food Insecurities

    The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed to reduce these comorbidities among food insecure PWH. The PI and staff…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Wake Forest Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04943861 on ClinicalTrials.gov

11. Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

    This pilot study aims to explore the potential benefits of consuming Greek bottarga (grey mullet fish roe) in individuals with at least one metabolic abnormality (low HDL cholesterol, high LDL cholesterol, high triglycerides, obesity, or HbA1c ≥ 5.7%) or a diagnosis of diabetes. Before initiating t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Cambridge Health Alliance, Sommerville, Massachusetts

    Run by

    Cambridge Health Alliance

    See if you can join NCT06988462 on ClinicalTrials.gov

12. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

    This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06007404 on ClinicalTrials.gov

13. Study EHR Risk Stratification Tools

    This study evaluates whether adding machine learning-based risk information to electronic health record (EHR) lab result messages helps older adults better understand their risk of developing diabetes and influences their emotional responses, quality of life, and healthcare use. Eligible participan…

    Stage

    Not phased

    Ages

    65 and older

    Site

    UCLA Health System, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06995378 on ClinicalTrials.gov

14. Mechanisms for Activation of Beige Adipose Tissue in Humans

    Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients

    Stage

    Phase 2

    Ages

    35 to 65

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Philip Kern

    See if you can join NCT04666636 on ClinicalTrials.gov

15. Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

    Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with normal blood sugar levels. The study will also test whether a single dose o…

    Stage

    Not phased

    Ages

    60 to 75

    Site

    UAB Comprehensive Cancer Center, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07546409 on ClinicalTrials.gov

16. Food and Metabolism Study

    In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.

    Stage

    Not phased

    Ages

    40 to 70

    Site

    Clinical Nutrition Research Center at IIT, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT07624500 on ClinicalTrials.gov

17. Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial

    The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs. urban/suburban nature areas/preserves) in adults with prediabetes. The main questions it …

    Stage

    Not phased

    Ages

    25 to 64

    Site

    Lake Forest Hospital, Lake Forest, Illinois

    Locations

    3 in total

    Run by

    University of Minnesota

    See if you can join NCT06365723 on ClinicalTrials.gov

18. Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

    We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

    Stage

    Not phased

    Ages

    40 to 65

    Site

    University of Arkansas for Medical Sciences, Little Rock, Arkansas

    Run by

    University of Arkansas

    See if you can join NCT06025292 on ClinicalTrials.gov

19. Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

    This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes. We will be comparing the responses in individuals who are taking metformin t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT07131384 on ClinicalTrials.gov

20. Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes

    Non-healthy eating habits and a lack of exercise contribute to prediabetes and type 2 diabetes (T2D). Evening snacking is linked to abnormal weight gain in adults and healthy adolescents. Most adolescents do not get enough exercise. This study aims to look at the benefits of more exercise and stopp…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Texas Children's Hospital / Children's Nutrition Research Center / Baylor College of Medicine, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT06782906 on ClinicalTrials.gov

21. Fiber mHealth Intervention for Prediabetes

    This is a single-arm feasibility trial to examine an mHealth intervention that combines high fiber education, home-delivered high fiber foods, and use of continuous glucose monitors.

    Stage

    Not phased

    Ages

    18 to 39

    Site

    University of Oklahoma Health Campus, Tulsa, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07491653 on ClinicalTrials.gov

22. Cardiometabolic Effects of Pecan Snacking in Prediabetes

    The purpose of this study is to investigate the effects of replacing snacks higher in saturated fats and added sugars with pecans on blood sugar control, heart health and diet quality in individuals with prediabetes. Participants will be randomized into one of two groups. Group 1 will consume 1.5 o…

    Stage

    Not phased

    Ages

    25 to 65

    Site

    The Pennsylvania State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT07235358 on ClinicalTrials.gov

23. Diabetes Clinical Decision Support

    The purpose of this study is to determine the impact of an electronic medical record clinical decision support tool on rates of dysglycemia in the hospital, and its clinical and economical outcomes. The study also evaluates the perspectives of providers regarding the tool's usefulness on disease ma…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Penn State Hershey Medical Center, Hershey, Pennsylvania

    Locations

    2 in total

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT05447806 on ClinicalTrials.gov

24. Night Owl Metabolism

    The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will und…

    Stage

    Not phased

    Ages

    18 to 23

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06507722 on ClinicalTrials.gov

25. CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes

    Prediabetes affects over one-third of adults in the United States, placing them at a higher risk for developing type 2 diabetes and heart disease, which can lead to serious health complications and increased medical costs. Although a program called the Diabetes Prevention Program (DPP) has been sho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Division of Population Health, Department of Medicine, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT07140848 on ClinicalTrials.gov