Posttraumatic Stress Disorder Clinical Trials

40 studies are recruiting for posttraumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Written Exposure Therapy for Veterans With SUD and PTSD

   The proposed project will evaluate the efficacy of written exposure therapy (WET) among Veterans engaged in substance use disorder (SUD) treatment, who present with co-occurring posttraumatic stress disorder (PTSD). While SUD treatment programs traditionally do not address PTSD, effective trauma tr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut

   Run by

   VA Office of Research and Development

   See if you can join NCT05327504 on ClinicalTrials.gov

2. Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

   The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Baylor University Medical Center, Dallas, Texas

   Locations

   3 in total

   Run by

   Baylor Research Institute

   See if you can join NCT06210711 on ClinicalTrials.gov

3. Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

   The goal of this clinical trial is to compare two different intensive formats of delivering cognitive-behavioral treatment for people with PTSD and anxiety disorders. The main questions it aims to answer are: * Is iTCBT delivered in individual and group formats more effective than TAU in improving …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Michael E. DeBakey VA Medical Center, Houston, Texas

   Run by

   Baylor College of Medicine

   See if you can join NCT05843695 on ClinicalTrials.gov

4. Mitigating PTSD-CUD After Sexual Assault

   683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD). The current proposal will test the acceptability, initial efficacy, and mechanisms underlying …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Harbor Shelter, Smithfield, North Carolina

   Locations

   6 in total

   Run by

   University of Nevada, Las Vegas

   See if you can join NCT05989841 on ClinicalTrials.gov

5. Evaluation of the PE Coach Mobile Application Among Veterans With PTSD

   Thousands of mental health mobile applications (apps) are available but limited research has been conducted on their effectiveness. VA has been a leader in mental health mobile app development and must research whether these apps work, and if so, how? PE Coach is a well-designed treatment companion…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington

   Run by

   VA Office of Research and Development

   See if you can join NCT04959695 on ClinicalTrials.gov

6. Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

   Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expre…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   National Intrepid Center of Excellence, Bethesda, Maryland

   Locations

   2 in total

   Run by

   Walter Reed National Military Medical Center

   See if you can join NCT05414708 on ClinicalTrials.gov

7. Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

   By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly that might improve treatment response. The investigators also want to l…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Augusta VA, Augusta, Georgia

   Locations

   4 in total

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07176273 on ClinicalTrials.gov

8. A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

   This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reducti…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06234969 on ClinicalTrials.gov

9. Mobile Anger Reduction Intervention

   Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD). Problematic anger is associated with significant functional impairment. In the current project, the investigators will c…

   Stage

   Not phased

   Ages

   Any age

   Site

   Durham VA Medical Center, Durham, NC, Durham, North Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT06094933 on ClinicalTrials.gov

10. Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

    This is a pilot randomized controlled trial to assess the impact of a first-line treatment for posttraumatic stress disorder (PTSD) (Cognitive Processing Therapy; CPT) versus waitlist control on mechanisms of cardiovascular disease (CVD) risk. Further, this study will test the hypothesis that CPT r…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06429293 on ClinicalTrials.gov

11. Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

    Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05427708 on ClinicalTrials.gov

12. Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors

    Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes, including posttraumatic stress and depression (affecting between 19-4…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05086757 on ClinicalTrials.gov

13. Dose Optimization of MDMA-Assisted Therapy for PTSD

    This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S. veterans with PTSD. Participants will complete from one to five cycles of MDMA-AT.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    James J. Peters VA Medical Center, The Bronx, New York

    Run by

    Bronx VA Medical Center

    See if you can join NCT06418178 on ClinicalTrials.gov

14. Mechanisms Underlying the Efficacy of Prolonged Exposure

    The primary objective of this research is to collect pilot data that demonstrates that proposed neural, psychophysiological and subjective markers measured before, during, and after treatment change over the course of Prolonged Exposure therapy (PE) for posttraumatic stress disorder (PTSD). The aim…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    VA Boston Healthcare System, Boston, Massachusetts

    Run by

    VA Boston Healthcare System

    See if you can join NCT05663151 on ClinicalTrials.gov

15. Biomarkers in the Retina for Prognosticating Mental Health Treatments

    Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. Previous studies suggest that there is a connection between the brain and the retina, and that the electroretinogram (ERG) may b…

    Stage

    Not phased

    Ages

    21 to 75

    Site

    VA Puget Sound Health Care System, Seattle, Washington

    Run by

    VA Puget Sound Health Care System

    See if you can join NCT06363968 on ClinicalTrials.gov