Posttraumatic Stress Disorder Clinical Trials

38 studies are recruiting for posttraumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

   The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Baylor University Medical Center, Dallas, Texas

   Locations

   3 in total

   Run by

   Baylor Research Institute

   See if you can join NCT06210711 on ClinicalTrials.gov

2. Dose Optimization of MDMA-Assisted Therapy for PTSD

   This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S. veterans with PTSD. Participants will complete from one to five cycles of MDMA-AT.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   James J. Peters VA Medical Center, The Bronx, New York

   Run by

   Bronx VA Medical Center

   See if you can join NCT06418178 on ClinicalTrials.gov

3. Mobile Anger Reduction Intervention

   Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD). Problematic anger is associated with significant functional impairment. In the current project, the investigators will c…

   Stage

   Not phased

   Ages

   Any age

   Site

   Durham VA Medical Center, Durham, NC, Durham, North Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT06094933 on ClinicalTrials.gov

4. Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples

   The goal of this clinical trial is to test an abbreviated, intensive, multi-couple group version of cognitive-behavioral conjoint therapy for PTSD (AIM-CBCT for PTSD) in an active military and veteran population. The main questions it aims to answer are: * Does AIM-CBCT for PTSD improve PTSD sympto…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Texas Health Science Center at San Antonio, San Antonio, Texas

   Run by

   Penn State University

   See if you can join NCT06047691 on ClinicalTrials.gov

5. Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers

   Healthcare workers and COVID-19 patients may experience psychological distress consequent to the pandemic, and are at particularly elevated risk for experiencing posttraumatic stress disorder (PTSD), based on evidence from previous infectious disease outbreaks. The best-validated treatment for PTSD…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04887116 on ClinicalTrials.gov

6. Focused Ultrasound for PTSD in Veterans

   The goal of this study is to develop a new, non-invasive brain stimulation modality called low intensity focused ultrasound (FUS) as a psychiatric rehabilitation treatment for posttraumatic stress disorder (PTSD). FUS delivers energy comparable to that involved in diagnostic ultrasound but in a mil…

   Stage

   Phase 2

   Ages

   22 to 70

   Site

   Providence VA Medical Center, Providence, RI, Providence, Rhode Island

   Run by

   VA Office of Research and Development

   See if you can join NCT06820138 on ClinicalTrials.gov

7. Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

   The purpose of this study to learn about patients' experience with the Trauma Resilience and Recovery program (TRRP) and/or the enhanced care group.

   Stage

   Not phased

   Ages

   16 and older

   Site

   George Washington University Hospital, Washington, Virginia

   Run by

   Medical University of South Carolina

   See if you can join NCT05497115 on ClinicalTrials.gov

8. Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

   The purpose of this study is to assess the safety and effectiveness of co-administered MDMA and psilocybin in military Veterans with a diagnosis of Posttraumatic Stress Disorder (PTSD). To apply or learn more, please view our website: https://hopkinspsychedelic.org/pamvet

   Stage

   Phase 1

   Ages

   21 and older

   Site

   Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT06989957 on ClinicalTrials.gov

9. Resilient Roots: Supporting Youth and Families

   Resilient Roots is integrated into the TRANSFORM Center to promote translation of research findings into clinical interventions, to inform the next generation of research on child abuse and neglect (CAN), and to facilitate dissemination of research and practice knowledge/skills to varied stakeholde…

   Stage

   Not phased

   Ages

   10 to 15

   Site

   Mt. Hope Family Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06535516 on ClinicalTrials.gov

10. Positive Processes and Transition to Health (PATH)

    The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stre…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Delaware, Newark, Delaware

    Locations

    3 in total

    Run by

    Case Western Reserve University

    See if you can join NCT06093906 on ClinicalTrials.gov

11. A Randomized Controlled Trial of a Web-Based Moral Elevation Intervention for Veterans With PTSD

    Despite the availability of evidence-based treatments for post-traumatic stress disorder (PTSD), there are many challenges to successful trauma recovery for Veterans including difficulties starting and completing these treatments and gaps in fully addressing additional important treatment targets i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Central Texas Veterans Health Care System, Temple, TX, Temple, Texas

    Run by

    VA Office of Research and Development

    See if you can join NCT06788678 on ClinicalTrials.gov

12. Investigating Cardiac Health of Adults With Trauma

    This project examines the impact of a healthy lifestyle intervention, specifically designed for adults with posttraumatic stress and identified cardiovascular risks.

    Stage

    Not phased

    Ages

    18 and older

    Site

    College of Psychology, Nova Southeastern University, Fort Lauderdale, Florida

    Run by

    Nova Southeastern University

    See if you can join NCT05700201 on ClinicalTrials.gov

13. Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

    Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stress (associated with intimate partner violence and/or other traumas) and depression negatively impact…

    Stage

    Not phased

    Ages

    15 and older

    Site

    Gugulethu Midwife Obstetric Unit (MOU), Cape Town, Western Cape

    Locations

    2 in total

    Run by

    Boston University Charles River Campus

    See if you can join NCT05624931 on ClinicalTrials.gov

14. Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

    MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress diso…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    UNM Center for Psychiatric Research, Albuquerque, New Mexico

    Locations

    2 in total

    Run by

    University of New Mexico

    See if you can join NCT06449326 on ClinicalTrials.gov

15. Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

    Posttraumatic stress disorder (PTSD) can have significant impairment on aspects of mental well-being (MWB) including functioning, loneliness, physical health, and quality of life. There are several evidence-based treatments (EBPs) effective in treating PTSD such as Cognitive Processing Therapy (CPT…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fully online study, Boston, Massachusetts

    Run by

    Boston University

    See if you can join NCT07250061 on ClinicalTrials.gov

16. Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

    Among individuals with opioid use disorder (OUD), posttraumatic stress disorder (PTSD) presents a significant clinical challenge. The prevalence of PTSD is substantially higher in individuals with OUD than in the general population, with nearly 90% reporting lifetime trauma exposure and 33% meeting…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Vemont, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT06288711 on ClinicalTrials.gov

17. Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients

    The goal of this clinical trial is to learn if a treatment for adults with PTSD called prolonged exposure + incentives (PE+) works to treat pregnant patients. The main question it aims to answer is: Does PE+ decrease PTSD symptoms? All participants will receive PE+ to see if their PTSD symptoms at …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Vermont, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT06670079 on ClinicalTrials.gov

18. A Precision Medicine Approach to Target Engagement for Emotion Regulation

    The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ohio State University, Columbus, Ohio

    Run by

    Matthew Southward, PhD

    See if you can join NCT05651295 on ClinicalTrials.gov

19. Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

    Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well as in more recent conflicts in Eastern Europe and the Middle East. This study aims to determine whet…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Anesthesiology Pain Medicine Center, Chicago, Illinois

    Locations

    3 in total

    Run by

    Northwestern University

    See if you can join NCT06608277 on ClinicalTrials.gov

20. Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

    The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequen…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Texas A&M University

    See if you can join NCT05959434 on ClinicalTrials.gov

21. Improving Cognitive Rehabilitation Outcomes

    Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality of life, and treatment response than either condition alone. Addition…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07055633 on ClinicalTrials.gov

22. Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder

    This study will investigate treatments for insomnia in Veterans who have posttraumatic stress disorder (PTSD). The purpose of this study is to compare a brief behavioral treatment for insomnia (BBTI) to a treatment that helps promote relaxation (progressive muscle relaxation training or PMRT). The …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

    Run by

    VA Office of Research and Development

    See if you can join NCT05780177 on ClinicalTrials.gov

23. Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

    This pilot pre-post trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia, sleep difficulties that remain after successful treatment of another condition, in the context of PTSD in understudied older adults…

    Stage

    Not phased

    Ages

    50 and older

    Site

    VA Greater Los Angeles Healthcare System, North Hills, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05516277 on ClinicalTrials.gov

24. Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

    Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes. A well-developed field of research suggests that alcohol misuse and posttraumatic stress disorder (PTSD) can lead t…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05786157 on ClinicalTrials.gov

25. Repurposing Low-Dose Clonidine for PTSD in Veterans

    Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Aurora Psychiatric Hospital, Wauwatosa, Wisconsin

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04877093 on ClinicalTrials.gov