Peripheral Arterial Disease Clinical Trials

35 studies are recruiting for peripheral arterial disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Chicago, Illinois 6 Cleveland, Ohio 6 Gainesville, Florida 6 Boston, Massachusetts 5 Dallas, Texas 5 Houston, Texas 5 Nashville, Tennessee 5 New Haven, Connecticut 5 Miami, Florida 4 New York, New York 4 Omaha, Nebraska 4 Detroit, Michigan 3 Little Rock, Arkansas 3 Norfolk, Virginia 3 Philadelphia, Pennsylvania 3 Rochester, Minnesota 3 San Antonio, Texas 3

Studies now recruiting

  1. EVERO Drug-coated Balloon (DCB) Randomized Trial

    The primary objective of the study is to evaluate the long-term safety and effectiveness of the Advance Evero™ 18 Everolimus-coated Percutaneous Transluminal Angioplasty Balloon Catheter (hereafter referred to as the Evero drug-coated balloon [DCB]) in the treatment of the femoropopliteal artery le…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale New Haven Hospital, New Haven, Connecticut
    Locations
    10 in total
    Run by
    Cook Research Incorporated

    See if you can join NCT07144150 on ClinicalTrials.gov

  2. Advanta VXT and Flixene PMCF Registry

    The purpose of the registry is to evaluate the long-term safety and performance of Advanta VXT and Flixene vascular grafts for repair or replacement of peripheral arteries. This registry is also intended to provide further data on the clinical usefulness of the Advanta VXT and Flixene vascular graf…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Atrium Medical Corporation

    See if you can join NCT07161583 on ClinicalTrials.gov

  3. Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

    The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    St. Vincent's Birmingham Hospital, Birmingham, Alabama
    Locations
    161 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07223593 on ClinicalTrials.gov

  4. The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

    The objective of this study is to establish reasonable assurance of safety and effectiveness of the Golazo® Peripheral Atherectomy System when used as indicated in 159 subjects with symptomatic infrainguinal peripheral arterial disease (PAD) in up to 20 investigational sites in the U.S.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Pulse Cardiovascular Institute, Scottsdale, Arizona
    Locations
    20 in total
    Run by
    Nipro Vascular Innovations Americas, Inc

    See if you can join NCT06321575 on ClinicalTrials.gov

  5. CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

    The primary goal of the study is to obtain effect size data on the use of Shockwave Intravascular Lithotripsy (IVL) technology in calcified common femoral lesions in patients with peripheral artery disease for a series of endpoints, including target lesion revascularization and health status, to en…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale New Haven Health, New Haven, Connecticut
    Locations
    2 in total
    Run by
    Yale University

    See if you can join NCT05145478 on ClinicalTrials.gov

  6. Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System

    The purpose of Case-Specific Health Care Professional (HCP) Clinical Survey of Liberant™ Thrombectomy System, also known as the Liberant Clinical Assessment, is to collect first-in-human clinical data to confirm the safety and performance of the Medtronic Liberant™ thrombectomy system when used for…

    Stage
    Not phased
    Ages
    22 and older
    Site
    MedStar Health, Washington D.C., District of Columbia
    Locations
    4 in total
    Run by
    Medtronic Endovascular

    See if you can join NCT07335341 on ClinicalTrials.gov

  7. Vascular Trial Associated Registry Pilot

    The purpose of this investigator-initiated, multicenter, open label, randomized trial is to evaluate 1 month vs. 6 months of dual antiplatelet therapy (DAPT) in patients undergoing lower extremity endovascular revascularization. We hypothesize that extending dual antiplatelet therapy (DAPT) to six …

    Stage
    Phase 4
    Ages
    45 and older
    Site
    Henry Ford Hospital, Detroit, Michigan
    Locations
    2 in total
    Run by
    Corewell Health West

    See if you can join NCT07076082 on ClinicalTrials.gov

  8. Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries

    This study will test whether using ultrasound imaging within blood vessels during minimally invasive treatment of leg arteries in patients with peripheral artery disease leads to better clinical outcomes.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Baylor Scott & White The Heart Hospital - Dallas, Dallas, Texas
    Locations
    6 in total
    Run by
    Baylor Research Institute

    See if you can join NCT07353905 on ClinicalTrials.gov

  9. Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention

    This is a preliminary prospective observational study measuring change in lower extremity temperature in response to revascularization procedure. The main question this study aims to answer is: - Are temperature measurements from a forward looking infrared (FLIR) camera of the lower extremity usefu…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    University Hospitals Ahuja Medical Center, Beachwood, Ohio
    Locations
    3 in total
    Run by
    University Hospitals Cleveland Medical Center

    See if you can join NCT06544135 on ClinicalTrials.gov

  10. The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants

    CG-0255 is a novel investigational prodrug of the active metabolite of Plavix®， but with different active metabolite conversion routes. This is a randomized, open-label and Plavix®-controlled study to compare the PK and PD of CG-0255 Besylate and Plavix® in healthy participants.

    Stage
    Phase 1
    Ages
    18 to 55
    Site
    Syneos Health, Miami, Florida
    Run by
    Shanghai CureGene Pharmaceutical Co., Ltd.

    See if you can join NCT07619885 on ClinicalTrials.gov

  11. Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

    Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD. Endothelial function is important because the endothelium contributes to the dilation of arteries during exe…

    Stage
    EARLY_Phase 1
    Ages
    50 to 75
    Site
    University of Nebraska - Omaha, Omaha, Nebraska
    Run by
    University of Nebraska

    See if you can join NCT06319339 on ClinicalTrials.gov

  12. The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

    The objective of this prospective, multicenter, randomized, controlled clinical trial is to demonstrate the superiority of the VBX Device for primary patency when compared to bare metal stenting in complex iliac occlusive disease.

    Stage
    Not phased
    Ages
    18 and older
    Site
    VA Long Beach Healthcare System, Long Beach, California
    Locations
    43 in total
    Run by
    W.L.Gore & Associates

    See if you can join NCT05811364 on ClinicalTrials.gov

  13. Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

    The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06952543 on ClinicalTrials.gov

  14. REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center

    The purpose of this study is to evaluate the effects of Blood Flow Restriction (BFR) training on walking function, health-related quality of life, and safety among adults with Peripheral Arterial Disease (PAD). The main aims of the study are: 1. Evaluate change in walking function among patients wi…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Tennessee Medical Center, Knoxville, Tennessee
    Run by
    University of Tennessee Graduate School of Medicine

    See if you can join NCT07223437 on ClinicalTrials.gov

  15. SELUTION4BTK Trial

    This study aims to demonstrate superior efficacy and equivalent safety of the SELUTION SLR™ DEB 014 compared to plain (uncoated) balloon angioplasty in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Chandler Regional Medical Center, Chandler, Arizona
    Locations
    48 in total
    Run by
    M.A. Med Alliance S.A.

    See if you can join NCT05055297 on ClinicalTrials.gov

  16. PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

    A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.

    Stage
    Not phased
    Ages
    18 to 95
    Site
    The Cardiac and Vascular Institute, Gainesville, Florida
    Locations
    30 in total
    Run by
    LimFlow, Inc.

    See if you can join NCT05313165 on ClinicalTrials.gov

  17. SMART Exercise for PAD

    Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lower extremity peripheral artery disease (PAD). However, travelling three times/week to a center for S…

    Stage
    Phase 3
    Ages
    50 and older
    Site
    Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Locations
    3 in total
    Run by
    Northwestern University

    See if you can join NCT06032065 on ClinicalTrials.gov

  18. Fisetin to Reduce Senescence and Mobility Impairment in PAD

    The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular adipose tissue and improve 6-minute walk distance in 34 people with peripher…

    Stage
    Phase 2
    Ages
    50 and older
    Site
    Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT06399809 on ClinicalTrials.gov

  19. Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

    The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with symptomatic peripheral artery disease.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Yale School of Medicine, New Haven, Connecticut
    Locations
    70 in total
    Run by
    Population Health Research Institute

    See if you can join NCT04774159 on ClinicalTrials.gov

  20. MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

    In our research, we are delving into whether taking MitoQ for six months can improve the symptoms and function of people diagnosed with peripheral artery disease, especially those who suffer from leg pain while walking, known as intermittent claudication. We will be checking if MitoQ helps people w…

    Stage
    Not phased
    Ages
    21 and older
    Site
    VA Medical Center, Omaha, Nebraska
    Run by
    University of Nebraska

    See if you can join NCT06409949 on ClinicalTrials.gov

  21. Randomized Clinical Trial for Ewing Amputation in the VA

    This study follows the Pilot Investigation of Ewing Amputation for Veterans with PAD Undergoing a Below Knee Amputation. The 2 year pilot feasibility phase has concluded recruitment and enrollment. The current phase is a 5 year randomized study of Ewing Below Knee Amputation vs. Standard Below Knee…

    Stage
    Not phased
    Ages
    Any age
    Site
    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia
    Locations
    3 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT05437562 on ClinicalTrials.gov

  22. Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

    XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection software, REDCAP.Data av…

    Stage
    Not phased
    Ages
    Any age
    Site
    Detroit Medical Center, Detroit, Michigan
    Locations
    24 in total
    Run by
    Baylor Research Institute

    See if you can join NCT01904851 on ClinicalTrials.gov

  23. Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

    The objective of this study is to determine if using Fuzzy Wale compression stockinet can assist in reducing the healing time and decrease costs in transtibial amputation patients as compared to standard of care treatment compression stocking.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06308562 on ClinicalTrials.gov

  24. Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

    The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UVA Student Health and Wellness Building, Charlottesville, Virginia
    Run by
    University of Virginia

    See if you can join NCT06009276 on ClinicalTrials.gov

  25. SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

    Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition. Ischemic leg pain drives disability in PAD patients and results from oxygen supply-demand mismatch, autonomic dysfunction, and muscle breakdown. This leg pain, which …

    Stage
    Not phased
    Ages
    19 to 89
    Site
    University of Nebraska Medical Center, Omaha, Nebraska
    Run by
    University of Nebraska

    See if you can join NCT06480786 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.