Pediatric Cancer Clinical Trials

32 studies are recruiting for pediatric cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Digital Art Therapy for Young Cancer Survivors

   This is a single-site, single-arm, interventional study assessing the feasibility of the ARTCan Therapy Application (App) and whether it is an acceptable means of administering art therapy to young adult cancer survivors. The ARTCan Therapy App guides participants through a 6-week digital art thera…

   Stage

   Not phased

   Ages

   18 to 25

   Site

   Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT06789666 on ClinicalTrials.gov

2. Biomarkers of Resiliency In Childhood Cancer Surgery

   This observational study is to better understand how children and their families recover after the stress of major surgery for cancer so that investigators can create ways to improve resilience during recovery. The main questions it aims to answer are: 1. Can information obtained from patients and …

   Stage

   Not phased

   Ages

   3 to 25

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06674811 on ClinicalTrials.gov

3. Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)

   The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.

   Stage

   Not phased

   Ages

   Up to 30

   Site

   Ann &Robert H Lurie Children's Hospital, Chicago, Illinois

   Run by

   Erin Rowell

   See if you can join NCT05309746 on ClinicalTrials.gov

4. Generating Novel Translational and Therapeutic Strategies Based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board (pedsETB)

   To evaluate the ability of a multidisciplinary and multisite group, the Pediatric Evolutionary Tumor Board (pedsETB), to develop additional therapeutic strategies in patients without curative options or with suboptimal outcomes.

   Stage

   Not phased

   Ages

   Any age

   Site

   Connecticut Children's Medical Center, Hartford, Connecticut

   Locations

   3 in total

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT06423950 on ClinicalTrials.gov

5. Lurbinectedin in FET-Fused Tumors

   The purpose of this study is to find out if a drug called lurbinectedin (the "study drug") is safe and effective at treating people with recurrent or relapsed solid tumors, including Ewing sarcoma.

   Stage

   Phase 1

   Ages

   10 and older

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   6 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT05918640 on ClinicalTrials.gov

6. Psychological Benefits of a Normalized Camping Experience for Children With Cancer

   Background: * Cancer has an enormous impact on the psychological and social well-being of the family unit. The life-threatening connotations of cancer single out the ill child from his peer/family group as one who is different, and often unable to maintain a normal lifestyle. Physical sequelae of c…

   Stage

   Not phased

   Ages

   7 to 25

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT00001186 on ClinicalTrials.gov

7. Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

   This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse intrinsic pontine glioma (DIPG). DIPG is a rare and aggressive brain tumor with limited treatment options. CAR T cell therapy uses a patient'…

   Stage

   Phase 2

   Ages

   1 to 26

   Site

   Seattle Children's Hospital, Seattle, Washington

   Locations

   6 in total

   Run by

   BrainChild Bio, Inc

   See if you can join NCT07680439 on ClinicalTrials.gov

8. Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)

   Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less than a quarter of patients with lung metastases will achieve…

   Stage

   Phase 2

   Ages

   2 to 25

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   5 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06458036 on ClinicalTrials.gov

9. Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients

   Pediatric cancer survivors have increased infection-related morbidity and mortality. This study will evaluate immune dysfunction following cancer directed systemic therapy completion, with attention to clinical relevance and infection rate in this population compared to healthy siblings, when appli…

   Stage

   Phase 2

   Ages

   2 to 21

   Site

   Levine Cancer Institute, Charlotte, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04948619 on ClinicalTrials.gov

10. LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients

    The purpose of this study is to see if there are physical and emotional benefits to participating in a structured exercise regimen for those who are ages 2-25, are newly diagnosed with a blood or solid tumor cancer, and are currently undergoing or will begin cancer treatment.

    Stage

    Not phased

    Ages

    2 to 25

    Site

    Levine Children's Hospital, Charlotte, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05058508 on ClinicalTrials.gov

11. Testing eSCCIP: An eHealth Psychosocial Intervention for English and Spanish Speaking Parents of Children With Cancer

    It is critical to provide accessible evidence-based psychosocial support to parents and caregivers of children with cancer (PCCC) in order to mitigate individual and family-level psychosocial risks. This effectiveness trial evaluates an eHealth intervention for English- and Spanish-speaking (PCCC) …

    Stage

    Not phased

    Ages

    Any age

    Site

    Nemours Children's Health, Delaware, Wilmington, Delaware

    Locations

    3 in total

    Run by

    Nemours Children's Clinic

    See if you can join NCT05294302 on ClinicalTrials.gov

12. Response to Influenza Vaccination in Pediatric Oncology Patients

    Influenza infection occurring during oncologic treatment or following hematopoietic cell transplantation (HCT) is associated with increased risk of morbidity in the form of lower respiratory tract infection (LRTI) and mortality relative to otherwise healthy patients. The study participants have bee…

    Stage

    Not phased

    Ages

    Up to 18

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT05384288 on ClinicalTrials.gov

13. LIFE Cancer Survivorship Database for Pediatric Cancer

    The purpose of this study is to develop a mechanism for utilizing the comprehensive clinical database of childhood cancer survivors at Childrens Hospital Los Angeles (CHLA) for research purposes. Using clinical information obtained from follow-up visits of childhood cancer survivors, the database w…

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT01518400 on ClinicalTrials.gov

14. Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

    The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples…

    Stage

    Not phased

    Ages

    Any age

    Site

    Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

    Run by

    Ann & Robert H Lurie Children's Hospital of Chicago

    See if you can join NCT05120518 on ClinicalTrials.gov

15. Multisite Implementation of COMPRENDO

    COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's of Alabama/University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    4 in total

    Run by

    University of California, San Diego

    See if you can join NCT06055296 on ClinicalTrials.gov

16. Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

    This is a phase I/II study to evaluate the safety of combining intravenous (IV) atezolizumab and bevacizumab every three weeks, with daily oral cyclophosphamide and pharmacokinetic (PK)-guided sorafenib in children and adolescent and young adults (AYA) with relapsed or refractory solid malignancies…

    Stage

    Phase 1

    Ages

    Up to 30

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Locations

    2 in total

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT05468359 on ClinicalTrials.gov

17. Video Inspired Discussions About Ethical Outcomes in Pediatrics

    The goal of this clinical trial is to learn if the VIDEO-PEDS intervention works to improve Goals of Care communication between clinicians and parents of children with cancer. The main questions it aims to answer are: Does the intervention improve Goals of Care documentation? Does it improve patien…

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's of Alabama at Birmingham, Birmingham, Alabama

    Locations

    4 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06786104 on ClinicalTrials.gov

18. UNC Childhood, Adolescent, and Young Adult Cancer Cohort

    Purpose: This study aims to create a registry of childhood, adolescent, and young adult patients with cancer (<40 years-old at cancer diagnosis), entitled the 'UNC Childhood, Adolescent, and Young Adult Cancer Cohort' (UNC-CAYACC). This resource will serve to support cancer outcomes research among …

    Stage

    Not phased

    Ages

    1 to 39

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT05096923 on ClinicalTrials.gov

19. Development and Evaluation of a Screening Approach for Sexual Dysfunction in AYA Patients With and Surviving Childhood Cancer

    Prior research determined adolescent and young adult-aged childhood cancer survivor (AYA-CCS) and medical provider acceptability of the SexFS Brief in a controlled research setting. Development of an acceptable, effective, and feasible screening approach will result in improved recognition of SD in…

    Stage

    Not phased

    Ages

    15 to 24

    Site

    Childrens Hospital Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT05524610 on ClinicalTrials.gov

20. Feasibility and Acceptability of Internet-based Parent-child Interaction Therapy (I-PCIT) in Pediatric Cancer

    This study is being done to learn whether a telehealth intervention called "Internet-Based Parent Child Interaction Therapy," or I-PCIT," can help parents improve the child's behavior if the child currently or previously went through cancer treatment. Parents who choose to be in this study will com…

    Stage

    Not phased

    Ages

    Any age

    Site

    Johns Hopkins All Children's Hospital, St. Petersburg, Florida

    Run by

    Johns Hopkins All Children's Hospital

    See if you can join NCT06346782 on ClinicalTrials.gov

21. Massage Impact on Sleep in Pediatric Oncology

    This study aims to determine the impact of massage therapy for pediatric patients receiving intensive chemotherapy or stem cell transplant (SCT).

    Stage

    Not phased

    Ages

    12 to 21

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06892158 on ClinicalTrials.gov

22. Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma

    This study aims to evaluate the efficacy of Laser Interstitial Thermal Therapy (LITT) in treating recurrent or progressive, low-grade gliomas (LGG) in pediatric, adolescent and young adult patients.

    Stage

    Not phased

    Ages

    2 to 25

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07506239 on ClinicalTrials.gov

23. Shareholder-driven Co-design and Piloting of Spanish Educational Videos About High Yield Pediatric Oncology Topics

    Families of children with cancer who speak languages other than English experience inequalities in healthcare, but little research has been done on solutions to improve care for these families. This study will partner parents with medical interpreters and clinicians to create educational videos abo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07288476 on ClinicalTrials.gov

24. PediRISE Feasibility

    The goal of this research study is to learn whether investigators can successfully give the PediRISE program to families-in other words, whether most families are interested in participating in a study about the PediRISE program, including a 50-50 chance of receiving standard usual care, and a 50-5…

    Stage

    Not phased

    Ages

    Up to 17

    Site

    University of California San Francisco, San Francisco, California

    Locations

    4 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT06283251 on ClinicalTrials.gov

25. Cancer Care Companion

    This study invites parents of children with cancer to use an electronic health record (EHR)-based communication tool, called the Cancer Care Companion, and assess the acceptability, appropriateness, and feasibility of the tool.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine/Saint Louis Children's Hospital, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07278778 on ClinicalTrials.gov