Parkinson's Disease Clinical Trials

40 studies are recruiting for parkinson's disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. At-home taVNS for Neurorehabilitation in Parkinson's Disease

   The goal of this clinical trial is to learn if taVNS works to treat symptoms of Parkinson's Disease in adults. It will also learn about the feasibility and preliminary efficacy of taVNS administered at home by the participant. The main questions it aims to answer are: 1. Is at-home taVNS feasible a…

   Stage

   Not phased

   Ages

   40 to 85

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT07536022 on ClinicalTrials.gov

2. rTMS to Improve Cognition in Parkinson's

   The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis i…

   Stage

   Phase 1

   Ages

   50 and older

   Site

   Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT03836950 on ClinicalTrials.gov

3. Ketamine for Veterans With Parkinson's Disease

   Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a lack of effective treatments for depression in PD…

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06231563 on ClinicalTrials.gov

4. Imaging Depression in Parkinson's Disease

   The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of depression.

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06402955 on ClinicalTrials.gov

5. Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners

   The goal of this feasibility study and clinical trial is to learn if an evidenced-based breathwork and meditation intervention (SKY Breath) will improve the mental and physical well-being of individuals with Parkinson's Disease (iPD) in stages 1, 2, and 3, under the age of 75 and their care partner…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Raw Kickboxing and Fitness, Coral Springs, Florida

   Locations

   3 in total

   Run by

   Nova Southeastern University

   See if you can join NCT06581523 on ClinicalTrials.gov

6. Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

   The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon ti…

   Stage

   Not phased

   Ages

   40 to 99

   Site

   Digestive Disease Associates, Branford, Connecticut

   Run by

   CND Life Sciences

   See if you can join NCT07217054 on ClinicalTrials.gov

7. Retinal Imaging in Neurodegenerative Disease

   This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT03233646 on ClinicalTrials.gov

8. Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

   This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targete…

   Stage

   Not phased

   Ages

   21 to 89

   Site

   University Of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05557864 on ClinicalTrials.gov

9. Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease

   Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease. Our study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence by …

   Stage

   Not phased

   Ages

   Any age

   Site

   Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio

   Run by

   VA Office of Research and Development

   See if you can join NCT05400499 on ClinicalTrials.gov

10. PET Imaging Evaluation of [11C]SY08

    The overall goal of the proposed research is to evaluate the use of [11C]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with Lewy Bodies (DLB) and healthy controls. The purpose of this study is to e…

    Stage

    EARLY_Phase 1

    Ages

    50 to 80

    Site

    MGH, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06098612 on ClinicalTrials.gov

11. Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

    Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US. The prevalence of sleep dysfunction in PD is estimated at nearly 80-90% which includes sleep fragmentation, insomnia, rapid eye mo…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Locations

    2 in total

    Run by

    University of Nebraska

    See if you can join NCT05070013 on ClinicalTrials.gov

12. Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

    The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor symptoms in individuals with Parkinson's disease. The main question it aims…

    Stage

    Not phased

    Ages

    21 to 80

    Site

    Stanford Neuroscience Health Center, Stanford, California

    Run by

    Helen M. Bronte-Stewart

    See if you can join NCT05968703 on ClinicalTrials.gov

13. Tenapanor in Synucleinopathy-Related Constipation

    Investigation of tenapanor as a potential treatment for synucleinopathy-associated constipation

    Stage

    Phase 2

    Ages

    50 to 89

    Site

    Cedar Valley Digestive Health Center, Waterloo, Iowa

    Run by

    Cedar Valley Digestive Health Center

    See if you can join NCT06460038 on ClinicalTrials.gov

14. The Parkinson's Genetic Research Study

    The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the Nati…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Emory University/ Wesley Woods Health Center, Atlanta, Georgia

    Locations

    5 in total

    Run by

    University of Washington

    See if you can join NCT01558479 on ClinicalTrials.gov

15. Modifiable Variables in Parkinsonism (MVP)

    We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD symptoms, and reduced rates of progression. After agreeing to participat…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Bastyr University, Kenmore, Washington

    Run by

    Bastyr University

    See if you can join NCT02194816 on ClinicalTrials.gov