Parkinson's Disease Clinical Trials

40 studies are recruiting for parkinson's disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Cleveland, Ohio 7 Chicago, Illinois 5 New Haven, Connecticut 5 Philadelphia, Pennsylvania 5 Atlanta, Georgia 4 Bethesda, Maryland 4 Boston, Massachusetts 4 Los Angeles, California 4 Miami, Florida 4 Nashville, Tennessee 4 New York, New York 4 San Francisco, California 4 Charlottesville, Virginia 3 Farmington Hills, Michigan 3 Houston, Texas 3 La Jolla, California 3 Lexington, Kentucky 3 Phoenix, Arizona 3 Portland, Oregon 3 Seattle, Washington 3 Tampa, Florida 3

Studies now recruiting

  1. Deep Brain Stimulation Surgery for Movement Disorders

    Background: - Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments. DBS uses a battery-powered device called a neurostimulator (like a pacemaker) that is placed under the skin in the chest. It is u…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT01581580 on ClinicalTrials.gov

  2. PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

    Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective: To learn wh…

    Stage
    Phase 1
    Ages
    18 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Mental Health (NIMH)

    See if you can join NCT04396873 on ClinicalTrials.gov

  3. Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

    This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressi…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT07442747 on ClinicalTrials.gov

  4. A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease

    The Goal of this study is to evaluate the safety, tolerability, and clinical responses following implantation of DSP-1083. Study enrolls both male and female patients in 2 cohorts. This study will be held in approximately 5-8 study sites in United States

    Stage
    Phase 1
    Ages
    40 to 72
    Site
    UCSD Medical Center, La Jolla, California
    Locations
    3 in total
    Run by
    Sumitomo Pharma America, Inc.

    See if you can join NCT06753331 on ClinicalTrials.gov

  5. Deep Brain Stimulation Therapy in Movement Disorders

    Background: - In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement. DBS might help people with movement disorders like Parkinson s disease (PD), dystonia, and essential tremor (ET). Objective: -…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02119611 on ClinicalTrials.gov

  6. A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease

    The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of LY3962681 in healthy volunteers and patients with Parkinson's disease. The study consists of two parts, the Single Ascending Dose (SAD) study and the Multiple Ascending Dose (MAD) stu…

    Stage
    Phase 1
    Ages
    30 to 80
    Site
    Aqualane Clinical Research, Naples, Florida
    Locations
    16 in total
    Run by
    Prevail Therapeutics

    See if you can join NCT06565195 on ClinicalTrials.gov

  7. Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease

    The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.

    Stage
    Not phased
    Ages
    18 and older
    Site
    The Ohio State University, Columbus, Ohio
    Run by
    Douglas Scharre

    See if you can join NCT03019757 on ClinicalTrials.gov

  8. Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

    The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming fea…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cedars Sinai Medical Center, Los Angeles, California
    Locations
    87 in total
    Run by
    Boston Scientific Corporation

    See if you can join NCT02071134 on ClinicalTrials.gov

  9. Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses

    The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device compared with the standard Alpha Omega device with either a tungsten standa…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT07868614 on ClinicalTrials.gov

  10. Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease

    Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor. This study uses wearable sensors to measure balance and uses deep brain stimulation elect…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
    Run by
    VA Office of Research and Development

    See if you can join NCT06405334 on ClinicalTrials.gov

  11. A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

    The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.

    Stage
    Phase 3
    Ages
    50 to 85
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    192 in total
    Run by
    Hoffmann-La Roche

    See if you can join NCT07174310 on ClinicalTrials.gov

  12. Speech Learning and Speech Production in Parkinson's Disease

    Parkinson's disease, a common movement disorder that results from a breakdown in the brain, often leads to challenges with talking, but less is known about the relationship between difficulties with talking and difficulties with learning to understand speech. By linking these two abilities in indiv…

    Stage
    Not phased
    Ages
    45 and older
    Site
    State University of New York at Buffalo, Buffalo, New York
    Run by
    State University of New York at Buffalo

    See if you can join NCT07403539 on ClinicalTrials.gov

  13. Natural History Protocol for Movement Disorders

    Background: A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking. Some cause reduced or slow movements. Movement disorders can cause disability in p…

    Stage
    Not phased
    Ages
    2 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT05413291 on ClinicalTrials.gov

  14. RESvEraTrol in Parkinson's Disease (RESET)

    This is an exploratory phase 2a study to investigate two doses of resveratrol (JotrolTM) vs placebo in individuals diagnosed with Parkinson's Disease (PD). Participants (n=30) will be randomized 1:1:1 into 3 groups and will receive oral JotrolTM vs placebo. Study drug will be titrated to reach a fi…

    Stage
    Phase 2
    Ages
    55 to 85
    Site
    Georgetown University Hospital, Washington D.C., District of Columbia
    Run by
    Georgetown University

    See if you can join NCT07592767 on ClinicalTrials.gov

  15. Parkinson's Foundation PD GENEration Genetic Registry

    Development of a central repository for PD-related genomic data for future research.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Barrow Neurological Institute, Phoenix, Arizona
    Locations
    70 in total
    Run by
    Parkinson's Foundation

    See if you can join NCT04994015 on ClinicalTrials.gov

  16. A Trial Investigating Lu AF28996 in Adults With Parkinson's Disease Who Have Motor Fluctuations

    This trial will evaluate the effects of Lu AF28996 in adults with Parkinson's disease (PD) experiencing motor fluctuations despite optimized non-invasive symptomatic treatment. These are individuals with PD who take medications to control movement symptoms, such as slowness, stiffness, and tremor, …

    Stage
    Phase 2
    Ages
    40 to 85
    Site
    Quest Research Institute - Alcanza - HyperCore - PPDS, Farmington Hills, Michigan
    Locations
    2 in total
    Run by
    H. Lundbeck A/S

    See if you can join NCT07514858 on ClinicalTrials.gov

  17. A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications

    This is an observational study in which data are collected and studied from Parkinson's disease patients who have movement symptoms despite taking standard Parkinson's medications. In observational studies, observations are made without any changes to the participant's healthcare or treatment plan.…

    Stage
    Not phased
    Ages
    45 to 75
    Site
    Banner Alzheimer's Institute (BAI)-Phoenix, Phoenix, Arizona
    Locations
    27 in total
    Run by
    Bayer

    See if you can join NCT07330258 on ClinicalTrials.gov

  18. Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease

    Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. This study will assess how effective Foslevodopa/Foscarbido…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Texas Movement Disorder Specialists /ID# 278565, Georgetown, Texas
    Locations
    10 in total
    Run by
    AbbVie

    See if you can join NCT07227896 on ClinicalTrials.gov

  19. A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery

    The investigators propose a Phase I single surgical-center, double-blinded randomized parallel clinical trial involving bilateral autologous peripheral nerve tissue (PNT) delivery into the NBM or the alternate target also affecting cognition in this population, the substantia nigra (SN), to address…

    Stage
    Phase 1
    Ages
    45 to 75
    Site
    University of Kentucky, Lexington, Kentucky
    Run by
    Craig van Horne, MD, PhD

    See if you can join NCT06683378 on ClinicalTrials.gov

  20. Physiological Brain Atlas Development

    The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

    Stage
    Not phased
    Ages
    6 to 90
    Site
    Vanderbilt Univeristy, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT00575081 on ClinicalTrials.gov

  21. Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease

    The study aims to evaluate the burden of tau pathology in people with Sporadic and LRRK2 PD via in vivo imaging using the tau tracer, [18F]PI-2620, and a high resolution PET camera, NeuroEXPLORER.

    Stage
    Phase 2
    Ages
    45 to 85
    Site
    Institute for Neurodegenerative Disorders / XingImaging, LLC, New Haven, Connecticut
    Run by
    Michael J. Fox Foundation for Parkinson's Research

    See if you can join NCT07020026 on ClinicalTrials.gov

  22. Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease

    This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patt…

    Stage
    Not phased
    Ages
    19 to 80
    Site
    Unversity of Nebraska Medical Center, Omaha, Nebraska
    Run by
    University of Nebraska

    See if you can join NCT04799470 on ClinicalTrials.gov

  23. Non-invasive VNS for Parkinson's Gait

    More than 110,000 US Veterans living with Parkinson's disease (PD) currently receive PD-related care and services from the VA. Fall prevention is a priority for Veterans living PD. Gait disturbances are a major cause for functional dependence and the largest risk factor for falls, institutionalizat…

    Stage
    Not phased
    Ages
    50 to 88
    Site
    Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois
    Run by
    VA Office of Research and Development

    See if you can join NCT06562569 on ClinicalTrials.gov

  24. Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease

    Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment and strabismus, frequently affects the quality of life in patients with Parkinson's disease. The investigators study aims to understand the location-specific effects of subthalamic region deep brai…

    Stage
    Not phased
    Ages
    Any age
    Site
    Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
    Run by
    VA Office of Research and Development

    See if you can join NCT06857851 on ClinicalTrials.gov

  25. Effects of Accelerated rTMS On Motor and Cognitive Function in Parkinson's Disease

    Parkinson's disease (PD) is a brain disorder that causes progressive problems with movement, such as slowness, stiffness, tremor, and difficulty walking. Many people with PD also develop problems with thinking and memory. Current medications can help control movement symptoms but often become less …

    Stage
    Not phased
    Ages
    50 to 90
    Site
    San Francisco Neurology and Sleep Center, San Francisco, California
    Run by
    San Francisco Neurology and Sleep Center

    See if you can join NCT07554833 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.