Pain, Postoperative Clinical Trials

42 studies are recruiting for pain, postoperative in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

   The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas

   Locations

   24 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05991453 on ClinicalTrials.gov

2. Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

   This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal A…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   8 in total

   Run by

   University of Michigan

   See if you can join NCT05722002 on ClinicalTrials.gov

3. Oral Methadone in Cardiac Surgery

   The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07221617 on ClinicalTrials.gov

4. Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia

   The purpose of this study is to find out which pain medication is more effective in reducing pain after nose surgery (rhinoplasty). The investigators are looking to find the best treatment to reduce discomfort and improve the healing process for patients having nose surgery.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Washington University, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07689162 on ClinicalTrials.gov

5. Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia

   The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA). In this randomized controlled trial, three analgesic regimens followin…

   Stage

   Phase 4

   Ages

   4 to 6

   Site

   Franciscan Children's Hospital, Brighton, Massachusetts

   Run by

   Boston University

   See if you can join NCT06757075 on ClinicalTrials.gov

6. Maternal Mindfulness: Depression and Postpartum Pain

   This phase I clinical trial tests the feasibility and safety of a self-guided, mobile mindfulness-based intervention to reduce post-cesarean pain and prevent postpartum depression.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Illinois Urbana-Champaign, Champaign, Illinois

   Run by

   University of Illinois at Urbana-Champaign

   See if you can join NCT05400382 on ClinicalTrials.gov

7. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

   Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pa…

   Stage

   Not phased

   Ages

   22 to 80

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT04144972 on ClinicalTrials.gov

8. Autonomic Neural Blockade in Bariatric Surgery

   The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants wil…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Endeavor Health, Evanston, Illinois

   Run by

   Endeavor Health

   See if you can join NCT07104825 on ClinicalTrials.gov

9. iPAWS: Improving Pain Management After Wisdom Tooth Extraction Surgery

   This is a clinical trial that will evaluate the feasibility and acceptability of a virtual brief program for adolescents and young adults undergoing wisdom tooth extraction and their parents. The program aims to teach youth safe and effective ways to manage post-surgical pain as well as decrease ri…

   Stage

   Not phased

   Ages

   15 to 20

   Site

   Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island

   Run by

   Brown University

   See if you can join NCT07731295 on ClinicalTrials.gov

10. Methadone for Post-operative Spine Surgery

    The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes in adult patients undergoing elective spine surgery, with the goal of improving postoperative analgesia and enhancing r…

    Stage

    Phase 4

    Ages

    18 to 120

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Brandon Knopp

    See if you can join NCT07517679 on ClinicalTrials.gov

11. Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures

    To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05415384 on ClinicalTrials.gov

12. Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

    The purpose of this study is to assess pharmacokinetics of liposomal bupivacaine (Exparel) after multilevel intercostal injections of this local anesthetic for pain control during and after thoracoscopic surgeries. The specific aim of this study is to evaluate plasma concentration of bupivacaine af…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Milton S. Hershey Medical Center, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT03737292 on ClinicalTrials.gov

13. Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

    In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce…

    Stage

    Phase 2

    Ages

    45 and older

    Site

    Stanford Health Care, Redwood City, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT04676802 on ClinicalTrials.gov

14. Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

    VATS/RATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS/RATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investi…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    University of Chicago, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT05351229 on ClinicalTrials.gov

15. Anesthetic Optimization in Pediatric LeFort Surgeries

    This study will propose and evaluate a standardized LeFort osteotomy anesthetic protocol for pediatric patients at Johns Hopkins Hospital. There are two cohorts to this study: a prospective cohort who will receive the study anesthesia protocol and a historical cohort that received standard of care.…

    Stage

    Not phased

    Ages

    14 and older

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05260320 on ClinicalTrials.gov

16. The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

    The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.

    Stage

    Phase 4

    Ages

    18 to 75

    Site

    Keck Medical Center of USC, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT05746143 on ClinicalTrials.gov

17. Opioid-Free Orthopaedics

    The goal of this investigation is to compare effectiveness of this multimodal regimen at controlling postoperative pain with and without the use of opioid medications.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    The Emory Clinic, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT04659317 on ClinicalTrials.gov

18. Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

    Participants who have a surgical procedure called Posterior Cervical (neck) Spine Surgery will normally need pain medication to relieve post operative pain. This usually includes opioid medications. In this study, the consented participant may receive a nerve block procedure, in addition to the pai…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Stony Brook University Hospital, Stony Brook, New York

    Run by

    Stony Brook University

    See if you can join NCT06570577 on ClinicalTrials.gov

19. Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

    This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy. The study will examine post-operative opioid usage, length of stay, return to work, and patient reported outcomes following these procedures.

    Stage

    Phase 3

    Ages

    18 to 85

    Site

    Hospital for Special Surgery, New York, New York

    Run by

    Hospital for Special Surgery, New York

    See if you can join NCT05058287 on ClinicalTrials.gov

20. Latinx Children and Surgery

    Over 60 million persons in the United States (US) identify themselves as Latinx and 25.6% are children under the age of 16. Surgical disparities for adults and children have been identified as a major problem in the US and can be experienced at multiple points along a patient's health care trajecto…

    Stage

    Not phased

    Ages

    2 to 7

    Site

    Children's Hospital of Orange County, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT06020677 on ClinicalTrials.gov

21. Intraperitoneal Infusion of Analgesic for Postoperative Pain Management

    The study is a prospective, double-blinded, placebo-controlled multi-center trial to measure if postoperative pain and the amount of narcotics used are reduced by a clinically significant amount in women undergoing minimally invasive hysterectomy receiving a continuous infusion of intraperitoneal (…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    MedStar Washington Hospital Center, Washington D.C., District of Columbia

    Locations

    2 in total

    Run by

    Ying Liu

    See if you can join NCT04130464 on ClinicalTrials.gov

22. Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

    Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive. After ankle fracture surgery, about 1 in 5 patients that did not take opioids before surgery become addicted to opioids after surger…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Washington University in St. Louis/Barnes Jewish Hospital, St Louis, Missouri

    Run by

    Jenna-Leigh Wilson

    See if you can join NCT06949826 on ClinicalTrials.gov

23. Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

    The purpose of this study is to determine if the method for injecting local anesthesia affects patients' pain and opioid usage after surgery. The investigators will compare subcutaneous anesthesia, injections of anesthesia under the skin, to a method called erector spinae plane block (ESPB). An ESP…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UMass Chan Medical School/UMass Memorial Medical Center, Worcester, Massachusetts

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT06528288 on ClinicalTrials.gov

24. Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population

    The goal of this randomized clinical trial is to determine if administration of Exparel via local infiltration for medial patellofemoral ligament (MPFL) reconstruction procedures in pediatric orthopaedic sports medicine patients provides significant pain relief and decreased narcotic use. The main …

    Stage

    Phase 2

    Ages

    13 to 21

    Site

    Texas Scottish Rite Hospital for Children, Frisco, Texas

    Run by

    Texas Scottish Rite Hospital for Children

    See if you can join NCT06559215 on ClinicalTrials.gov

25. Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

    The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients unde…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Sanford Health, Fargo, North Dakota

    Run by

    Sanford Health

    See if you can join NCT03858231 on ClinicalTrials.gov