Overweight Clinical Trials

58 studies are recruiting for overweight in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

   Background: Artificial sweeteners like sucralose are found in many foods and drinks. Sucralose might affect hormones and cause health changes. Objective: To see if sucralose changes how medicines are absorbed and processed, how hormones are secreted, gut bacteria, and how fat cells are metabolized.…

   Stage

   Phase 2

   Ages

   18 to 60

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT03407079 on ClinicalTrials.gov

2. HealthyTogether: RCT of a Dyadic Weight Management Intervention

   Four in five Veterans have overweight or obesity. However, few eligible Veterans achieve meaningful weight loss in VA's national MOVE! Weight Management Program. Family and friends strongly influence a person's health behaviors and weight. Including a close family member or friend in weight managem…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06619041 on ClinicalTrials.gov

3. A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

   The main purpose of this study is to understand how safe and well-tolerated LY4174794 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4174794 gets into the bloodstream and how long it takes the body to eliminate it. Particip…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   ICON Early Phase Services, LLC, San Antonio, Texas

   Locations

   3 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07654972 on ClinicalTrials.gov

4. A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

   This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide …

   Stage

   Phase 3

   Ages

   8 to 18

   Site

   Neighborhood Healthcare, Escondido, California

   Locations

   121 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07253285 on ClinicalTrials.gov

5. A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

   The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.

   Stage

   Phase 3

   Ages

   6 to 17

   Site

   Lucas Research, Inc, Morehead City, North Carolina

   Locations

   117 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06672549 on ClinicalTrials.gov

6. A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

   The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the…

   Stage

   Phase 3

   Ages

   12 to 17

   Site

   Saitama Medical University Hospital, Iruma-Gun,

   Locations

   34 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06672939 on ClinicalTrials.gov

7. A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

   The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants w…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   MFA Clinical Research, Tuscaloosa, Alabama

   Locations

   162 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07321886 on ClinicalTrials.gov

8. A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight

   The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 …

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   ICON Early Phase Services, San Antonio, Texas

   Locations

   2 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07738614 on ClinicalTrials.gov

9. A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

   The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like midazolam, caffeine and warfarin in participants living with overweight or obesity.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Altasciences Clinical LA, Inc., Cypress, California

   Run by

   Novo Nordisk A/S

   See if you can join NCT07710768 on ClinicalTrials.gov

10. AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the tr…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Neighborhood Healthcare, Escondido, California

    Locations

    81 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07509307 on ClinicalTrials.gov

11. Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

    Study GSBR-1290-12 is a Phase 3 pivotal, multicenter, global, randomized, placebo-controlled, double-blind study to investigate the long-term efficacy, safety, and tolerability of 3 maintenance doses of aleniglipron once daily (QD) compared with placebo, when used in combination with a reduced-calo…

    Stage

    Phase 3

    Ages

    18 to 79

    Site

    ACCOMPLISH-1 Research Site, Clearwater, Florida

    Locations

    71 in total

    Run by

    Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

    See if you can join NCT07654361 on ClinicalTrials.gov

12. A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

    The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will …

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona

    Locations

    40 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07589608 on ClinicalTrials.gov

13. Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

    Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the stud…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT06325722 on ClinicalTrials.gov

14. A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity

    This study is testing a new medicine, NNC6989-0001, to test it is safe and tolerable for healthy people living with overweight or obesity. NNC6989-0001 is still being tested in studies and is not yet available for prescription by doctors. In this study, participants will receive either NNC6989-0001…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    ICON Early Phase Services, LLC, Lenexa, Kansas

    Run by

    Novo Nordisk A/S

    See if you can join NCT07437079 on ClinicalTrials.gov

15. Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

    The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Diablo Clinical Research, Inc., Walnut Creek, California

    Locations

    11 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07607587 on ClinicalTrials.gov

16. Night Owl Metabolism

    The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will und…

    Stage

    Not phased

    Ages

    18 to 23

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06507722 on ClinicalTrials.gov

17. Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer

    This trial studies how well nutrition and exercise interventions work in reducing androgen deprivation therapy-induced obese frailty in prostate cancer survivors. Individualized nutrition and exercise advice for prostate cancer patients on androgen deprivation therapy may help to reduce obese frail…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Roswell Park Cancer Institute, Buffalo, New York

    Run by

    Roswell Park Cancer Institute

    See if you can join NCT03880422 on ClinicalTrials.gov

18. Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes

    The purpose of this study is: * To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program. * To see if…

    Stage

    Not phased

    Ages

    21 to 50

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT07573228 on ClinicalTrials.gov

19. A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight

    The purpose of this clinical study is to find out if NNC0662-0419 is safe and effective to be taken together with other medicines, like birth control pills, and emptying of the stomach in women not able to become pregnant living with overweight or obesity. There are 3 study treatments in this study…

    Stage

    Phase 1

    Ages

    18 to 64

    Site

    Altasciences Clinical Kansas, Inc., Overland Park, Kansas

    Run by

    Novo Nordisk A/S

    See if you can join NCT07525791 on ClinicalTrials.gov

20. A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity

    The purpose of this clinical study is to find out if UBT251 is safe and effective for treating people who are living with overweight or obesity. Participants will get either UBT251 (the treatment being tested) or Placebo (a treatment that has no active medicine in it), which treatment participants …

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Altasciences Clinical LA, Inc., Cypress, California

    Locations

    3 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07395687 on ClinicalTrials.gov

21. A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

    The specific aim of this study is to examine the Safety, Tolerability and Pharmacokinetic of Semaglutide Nasal Spray compared with placebo and positive control in Adult Overweight or Obese Participants.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Frontage Clinical Services, Inc., Secaucus, New Jersey

    Run by

    Shanghai World Leader Pharmaceutical Co., Ltd.

    See if you can join NCT07465965 on ClinicalTrials.gov

22. Avoid and Resist Strategies for Weight Management

    The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an impulse control training strategy (RESIST).

    Stage

    Not phased

    Ages

    14 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT05143931 on ClinicalTrials.gov

23. Semaglutide for Post-Smoking Cessation Weight Management

    This trial will examine the effect of semaglutide 2.4mg on changes in body weight, body composition, and peripheral and central mechanisms that control appetite, satiety, and food intake in the context of smoking cessation.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    The University of Texas at Austin, Austin, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06173778 on ClinicalTrials.gov

24. The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

    A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with microbial derived metabolites (SCFAs, BAs, ellagitan…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    University of California, Davis; Department of Nutrition, Davis, California

    Run by

    University of California, Davis

    See if you can join NCT04248127 on ClinicalTrials.gov

25. Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

    evaluation of the EndoZip system procedure compared to the Apollo ESG procedure in obese patients.

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Lenox Hill Hospital | Northwell Health, New York, New York

    Locations

    2 in total

    Run by

    Nitinotes Surgical Ltd.

    See if you can join NCT07090005 on ClinicalTrials.gov