Overweight Clinical Trials

58 studies are recruiting for overweight in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Houston, Texas 20 San Antonio, Texas 19 Austin, Texas 14 Las Vegas, Nevada 14 Miami, Florida 14 Cincinnati, Ohio 13 Morehead City, North Carolina 13 Chicago, Illinois 12 Dallas, Texas 12 Jacksonville, Florida 12 Birmingham, Alabama 10 Escondido, California 10 Louisville, Kentucky 10 Tucson, Arizona 10 Atlanta, Georgia 9 Walnut Creek, California 9 Greensboro, North Carolina 8 Lawrenceville, Georgia 8 Phoenix, Arizona 8 St Louis, Missouri 8 Baltimore, Maryland 7 Columbus, Ohio 7 Honolulu, Hawaii 7 Los Angeles, California 7 Nashville, Tennessee 7 New York, New York 7 Orlando, Florida 7 Rochester, New York 7 Tustin, California 7 Weslaco, Texas 7 Wilmington, North Carolina 7 Baton Rouge, Louisiana 6 City of Saint Peters, Missouri 6 DeSoto, Texas 6 Indianapolis, Indiana 6 Monroe, North Carolina 6 Pittsburgh, Pennsylvania 6 Rolling Hills Estates, California 6 San Diego, California 6 Southfield, Michigan 6 Sugar Land, Texas 6 Topeka, Kansas 6 Union City, Georgia 6 Boston, Massachusetts 5 Charlotte, North Carolina 5 Durham, North Carolina 5 El Paso, Texas 5 Fleming Island, Florida 5 Greenville, South Carolina 5 Gulfport, Mississippi 5 Meridian, Idaho 5 Mesquite, Texas 5 Miami Lakes, Florida 5 Minneapolis, Minnesota 5 Omaha, Nebraska 5 Pembroke Pines, Florida 5 Philadelphia, Pennsylvania 5 Renton, Washington 5 Richmond, Virginia 5 Salt Lake City, Utah 5

Studies now recruiting

  1. Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

    Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem. Objective: To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) aff…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT06044935 on ClinicalTrials.gov

  2. Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

    Obesity is a condition where a person has excessive body fat, defined by a body mass index (BMI) of 30 kg/m2 or higher. The goal of this study is to evaluate the effect of various doses of ABBV-295 compared to placebo on reducing body weight at Week 32 in participants with obesity or overweight wit…

    Stage
    Phase 2
    Ages
    18 to 75
    Site
    Cahaba Research - Pelham /ID# 282381, Pelham, Alabama
    Locations
    45 in total
    Run by
    AbbVie

    See if you can join NCT07752979 on ClinicalTrials.gov

  3. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

    Study ASC30-302 (AURORA-2) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight and…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    AURORA-2 Clinical Site, Phoenix, Arizona
    Locations
    135 in total
    Run by
    Ascletis Pharma (China) Co., Limited

    See if you can join NCT07743450 on ClinicalTrials.gov

  4. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

    Study ASC30-301 (AURORA-1) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight wit…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    AURORA-1 Clinical Site, Phoenix, Arizona
    Locations
    122 in total
    Run by
    Ascletis Pharma (China) Co., Limited

    See if you can join NCT07743463 on ClinicalTrials.gov

  5. AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the s…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Artemis Insitute for Clin Res, San Diego, California
    Locations
    80 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07571005 on ClinicalTrials.gov

  6. A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

    This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatmen…

    Stage
    Phase 3
    Ages
    18 to 79
    Site
    ACCOMPLISH-2 Research Site, Birmingham, Alabama
    Locations
    74 in total
    Run by
    Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

    See if you can join NCT07654374 on ClinicalTrials.gov

  7. A Research Study Investigating How a New Medicine NNC0113-5840 Works in People With Overweight or Obesity

    The purpose of this clinical study is to find out if NNC0113-5840 is safe for treating people with excess body weight. There are 2 study treatments in this study, participants will get either NNC0113-5840 (the product being tested) or Placebo (treatment that has no active medicine in it), Which tre…

    Stage
    Phase 1
    Ages
    18 to 55
    Site
    PAREXEL Glendale/LA EPCU, Glendale, California
    Locations
    2 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07566390 on ClinicalTrials.gov

  8. AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will ei…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Dignity Health, Mercy Gilbert, Gilbert, Arizona
    Locations
    92 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07571109 on ClinicalTrials.gov

  9. Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

    The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be u…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Uni of Alabama at Birmingham, Birmingham, Alabama
    Locations
    62 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07770841 on ClinicalTrials.gov

  10. A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

    The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newl…

    Stage
    Phase 2
    Ages
    18 to 75
    Site
    The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona
    Locations
    56 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT06143956 on ClinicalTrials.gov

  11. A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

    The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

    Stage
    Phase 2
    Ages
    18 to 75
    Site
    Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC, Gilbert, Arizona
    Locations
    42 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07215559 on ClinicalTrials.gov

  12. A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

    The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Birmingham Clinical Research, Birmingham, Alabama
    Locations
    157 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07282600 on ClinicalTrials.gov

  13. A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

    The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight. YDAO is a master protocol designed to support two independent studies: YSA1 and YSA2. Study YSA1 will include participants who…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Cullman Clinical Trials, Cullman, Alabama
    Locations
    115 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07369011 on ClinicalTrials.gov

  14. A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

    The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Birmingham Clinical Research, Birmingham, Alabama
    Locations
    187 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07392190 on ClinicalTrials.gov

  15. AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

    The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the trea…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Univ of Alabama Birmingham, Birmingham, Alabama
    Locations
    74 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07533175 on ClinicalTrials.gov

  16. A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

    The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a plac…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    San Fernando Valley Health Institute, Canoga Park, California
    Locations
    50 in total
    Run by
    Pfizer

    See if you can join NCT07595549 on ClinicalTrials.gov

  17. A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight

    The purpose of this clinical study is to look at how well a study medicine called cagrilintide helps people living with excess body weight to lose weight. Participants will either get cagrilintide, the active study medicine being tested or placebo, a medicine that has no active medicine in it. Whic…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Hope Clin Res & Wellness, Conyers, Georgia
    Locations
    36 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07745504 on ClinicalTrials.gov

  18. A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity

    The purpose of the study is to find out if NNC0721-8060 is safe and how it works in people living with overweight or obesity.

    Stage
    Phase 1
    Ages
    18 to 55
    Site
    ICON Early Phase Services, LLC, Lenexa, Kansas
    Locations
    2 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07767175 on ClinicalTrials.gov

  19. Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

    The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

    Stage
    Phase 3
    Ages
    45 to 99
    Site
    Alliance For Multispecialty Research - Daphne, Daphne, Alabama
    Locations
    783 in total
    Run by
    Amgen

    See if you can join NCT07037433 on ClinicalTrials.gov

  20. Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

    The primary objective of the study is to determine the effects of ribupatide (KAI-9531) subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Kailera Clinical Site, Anniston, Alabama
    Locations
    104 in total
    Run by
    Kailera

    See if you can join NCT07284875 on ClinicalTrials.gov

  21. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

    The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity and type 2 diabetes mellitus. Trial 20210182 is extension of trial 20210184 (NCT06858878).

    Stage
    Phase 3
    Ages
    18 to 99
    Site
    Gilbert Center for Family Medicine, Gilbert, Arizona
    Locations
    37 in total
    Run by
    Amgen

    See if you can join NCT07684144 on ClinicalTrials.gov

  22. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

    The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).

    Stage
    Phase 3
    Ages
    18 to 99
    Site
    Pinnacle Research Group LLC, Anniston, Alabama
    Locations
    87 in total
    Run by
    Amgen

    See if you can join NCT07684235 on ClinicalTrials.gov

  23. Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

    The researchers will conduct 'Taxi ROADmAP (Realizing Optimization Around Diet And Physical activity)', which also utilizes MOST, and the same 4 obesity intervention components as in SANOS, but targets the overweight/obesity crisis in another at-risk, low socioeconomic status (SES) population, taxi…

    Stage
    Phase 2
    Ages
    21 and older
    Site
    Mexican Consulate's Ventanilla de Salud (VDS), New York, New York
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT05770570 on ClinicalTrials.gov

  24. Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

    The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.

    Stage
    Not phased
    Ages
    45 to 65
    Site
    Georgia State University, Atlanta, Georgia
    Run by
    Georgia State University

    See if you can join NCT06735599 on ClinicalTrials.gov

  25. Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

    The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.

    Stage
    Not phased
    Ages
    20 to 65
    Site
    Georgia State University, Atlanta, Georgia
    Run by
    Georgia State University

    See if you can join NCT06735651 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.