Overweight and Obesity Clinical Trials

34 studies are recruiting for overweight and obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cottonseed Oil Versus Matched PUFA Effects

   Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporati…

   Stage

   Not phased

   Ages

   25 to 75

   Site

   University of Georgia, Athens, Georgia

   Run by

   University of Georgia

   See if you can join NCT06382298 on ClinicalTrials.gov

2. Intermittent Cottonseed Oil Consumption

   Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporati…

   Stage

   Not phased

   Ages

   25 to 75

   Site

   University of Georgia, Athens, Georgia

   Run by

   University of Georgia

   See if you can join NCT07246408 on ClinicalTrials.gov

3. Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

   The researchers will conduct 'Taxi ROADmAP (Realizing Optimization Around Diet And Physical activity)', which also utilizes MOST, and the same 4 obesity intervention components as in SANOS, but targets the overweight/obesity crisis in another at-risk, low socioeconomic status (SES) population, taxi…

   Stage

   Phase 2

   Ages

   21 and older

   Site

   Mexican Consulate's Ventanilla de Salud (VDS), New York, New York

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT05770570 on ClinicalTrials.gov

4. Effects of Watermelon or Low-fat Cookie Consumption on Wellness

   The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.

   Stage

   Not phased

   Ages

   18 to 50

   Site

   School of Exercise and Nutritional Sciences, San Diego, California

   Run by

   San Diego State University

   See if you can join NCT06323070 on ClinicalTrials.gov

5. Human Models of Selective Insulin Resistance: Alpelisib, Part I

   The goal of this clinical trial is to understand how the blood sugar-lowering hormone insulin works in healthy adults versus those who are at risk for type 2 diabetes. The study will use a drug called alpelisib, which interferes with insulin's actions in the body, to answer the study's main questio…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06354088 on ClinicalTrials.gov

6. Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual Disabilities

   The goal of this study is to see if adding hands-on cooking classes to a weight management program (called Chef-ID) helps young adults with intellectual disabilities lose more weight and keep it off compared to a standard weight loss program. The study will last 24 months and include three phases: …

   Stage

   Not phased

   Ages

   18 to 35

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06961591 on ClinicalTrials.gov

7. Circadian Intervention to Improve Cardiometabolic Health

   The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian interven…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   College of Health Research Complex--University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT05943626 on ClinicalTrials.gov

8. Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

   The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (interve…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   College of Health Research Complex--University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT06180837 on ClinicalTrials.gov

9. Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

   The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible partic…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boise VA Medical Center, Boise, Idaho

   Locations

   5 in total

   Run by

   Seattle Institute for Biomedical and Clinical Research

   See if you can join NCT06390345 on ClinicalTrials.gov

10. An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents

    The goal of this clinical trial is to learn about cardiovascular disease risk among adolescent girls with overweight/obesity. The main questions this trial aims to answer are: 1. Does an acceptance-based healthy lifestyle intervention demonstrate more weight loss than a health education interventio…

    Stage

    Not phased

    Ages

    14 to 19

    Site

    Drexel University, Philadelphia, Pennsylvania

    Run by

    Nemours Children's Clinic

    See if you can join NCT06147973 on ClinicalTrials.gov

11. Time-restricted Eating for Postpartum Weight Loss

    This study is being done to assess the feasibility and acceptability of a time-restricted eating intervention among postpartum women with overweight/obesity.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06491537 on ClinicalTrials.gov

12. Breathing & Blood Pressure

    The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT05632406 on ClinicalTrials.gov

13. Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes

    This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    5 in total

    Run by

    Indiana University

    See if you can join NCT05124808 on ClinicalTrials.gov

14. Healthy for Two-Home Visiting (H42-HV): Health Coaching for Pregnant Women

    The purpose of this study is to compare the effectiveness of H42-HV integrated into home visiting compared with usual home visiting services in reducing postpartum weight retention (difference between pre-pregnancy weight and weight at 6 months postpartum) among pregnant and postpartum participants…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins School of Nursing, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05619705 on ClinicalTrials.gov

15. Pregnancy Exercise Mode Effect on Childhood Obesity

    The overall objective of this proposal is to conduct a longitudinal prospective study of overweight/obese (OW/OB) pregnant women and their offspring to determine which prenatal exercise mode will have the greatest impact on maternal and infant cardiometabolic health. This information may lead to cl…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    East Carolina University, Greenville, North Carolina

    Run by

    East Carolina University

    See if you can join NCT04805502 on ClinicalTrials.gov

16. A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity

    The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending doses of WVE-007 when administered subcutaneously (SC) . Part A is a single ascending dose study in adults living with overweight and obesity. The Part B of the study is a repeat dose…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    Parexel International-EPCU Baltimore, Baltimore, Maryland

    Locations

    6 in total

    Run by

    Wave Life Sciences USA, Inc.

    See if you can join NCT06842186 on ClinicalTrials.gov

17. Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

    Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaire…

    Stage

    Not phased

    Ages

    18 to 42

    Site

    Pennington Biomedical Research Center, Baton Rouge, Louisiana

    Run by

    Pennington Biomedical Research Center

    See if you can join NCT04583514 on ClinicalTrials.gov

18. Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

    The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal…

    Stage

    Not phased

    Ages

    30 to 55

    Site

    University of Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT04791371 on ClinicalTrials.gov

19. PILI 'Āina Household

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no nā Po'e Hawai'i, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526273 on ClinicalTrials.gov

20. 'Ai Pono Cooking Demonstrations

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no na Poe Hawaii, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526650 on ClinicalTrials.gov

21. Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

    The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05107908 on ClinicalTrials.gov

22. Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0

    The goal of this clinical trial is to see if the enhanced HMZ 2.0 intervention with new control system/digital platform to regulate gestational weight gain (GWG) and impact maternal-infant outcomes while collecting implementation data works and can be given to other pregnant women in various settin…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Pennsylvania State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT05807594 on ClinicalTrials.gov

23. Metformin IN Asthma for Overweight and Obese Individuals (MINA)

    This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06273072 on ClinicalTrials.gov

24. Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

    The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UVA Student Health and Wellness Building, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06009276 on ClinicalTrials.gov

25. Optimal Digital Weight Loss Treatment for Rural Individuals

    Over 130 million adults in the US experience overweight and obesity, and rural communities experience significantly higher rates of obesity and related chronic diseases. Although lifestyle interventions successfully produce clinically significant weight losses, the availability of weight management…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Carolina, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT06105957 on ClinicalTrials.gov