Opioid Use Clinical Trials

42 studies are recruiting for opioid use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

   This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, ha…

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Emory University Clinical Research Network, Atlanta, Georgia

   Locations

   6 in total

   Run by

   Emory University

   See if you can join NCT05834478 on ClinicalTrials.gov

2. Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

   The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic …

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas

   Locations

   2 in total

   Run by

   Texas Tech University Health Sciences Center

   See if you can join NCT06903819 on ClinicalTrials.gov

3. Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

   The purpose of this study is to determine if the method for injecting local anesthesia affects patients' pain and opioid usage after surgery. The investigators will compare subcutaneous anesthesia, injections of anesthesia under the skin, to a method called erector spinae plane block (ESPB). An ESP…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UMass Chan Medical School/UMass Memorial Medical Center, Worcester, Massachusetts

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT06528288 on ClinicalTrials.gov

4. Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

   Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benzodiazepines, which can have severe side effects and can be ineffective. Interventions combining vir…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT04912531 on ClinicalTrials.gov

5. Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal

   A placebo-controlled trial in which male and female outpatients with an opioid use disorder who express interest in extended-release injectable naltrexone (XR-NTX) are randomized 1:1 to lofexidine/pregabalin or lofexidine/pregabalin placebo for withdrawal management and offered XR-NTX if after comp…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Pennsylvania, Treatment Research Center, Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pennsylvania

   See if you can join NCT05995535 on ClinicalTrials.gov

6. Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

   Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "conti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rogers Behavioral Health, Oconomowoc, Wisconsin

   Locations

   2 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04927143 on ClinicalTrials.gov

7. Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

   The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients unde…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   Sanford Health, Fargo, North Dakota

   Run by

   Sanford Health

   See if you can join NCT03858231 on ClinicalTrials.gov

8. Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage

   The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH). It will also study the safety of this treatment.

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   University of Texas Medical Branch, Galveston, Galveston, Texas

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07294118 on ClinicalTrials.gov

9. VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

   The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and thus residual opioids in circulation.

   Stage

   Not phased

   Ages

   Any age

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06456268 on ClinicalTrials.gov

10. Transcutaneous Auricular Neurostimulation After Lumbar Surgery

    The purpose of this study, entitled "Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Non-Opioid Pain Management Therapy for Patients Undergoing Lumbar Surgery", is to demonstrate whether transcutaneous auricular neurostimulation (tAN) can non-invasively reduce the perception of p…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06100172 on ClinicalTrials.gov

11. Opioid Dispenser for Microdiscectomy/Laminectomy

    The opioid crisis continues to plague the United States. While great strides have been made nationwide to decrease overprescribing, improvements are still needed to appropriately educate patients on the safe and responsible use, storage and disposal of opioids. Pain after surgery is often treated w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hospital for Special Surgery, New York, New York

    Run by

    Hospital for Special Surgery, New York

    See if you can join NCT06358040 on ClinicalTrials.gov

12. Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

    The goal of this clinical trial is to evaluate the effectiveness of a social network intervention to recruit people who inject drugs and their networks for HIV testing and linkage to HIV prevention and treatment services in Maryland. Study aims are to determine the effectiveness of a social network…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Frederick County Health Department, Street Safe Program, Frederick, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06103370 on ClinicalTrials.gov

13. Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment

    The overarching goal of this project is to increase the availability of OUD treatment in rural counties in the state of Georgia by using Emergency Department (ED)-based telehealth strategies to initiate MOUD and connect patients to treatment. The investigators will implement a novel collaboration b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Georgia Poison Center, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT05711056 on ClinicalTrials.gov

14. Young Houston Emergency Opioid Engagement System

    The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare difference…

    Stage

    Phase 4

    Ages

    13 to 17

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04811014 on ClinicalTrials.gov

15. Mindfulness in Endometrial and Cervical Cancer

    Patients with endometrial cancer who will be undergoing surgery or patients with cervical cancer who will be treated with chemoradiation will be randomized to utilize the Headspace smartphone application or not prior to their anticipated treatment.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Saint Louis University, St Louis, Missouri

    Run by

    St. Louis University

    See if you can join NCT04512144 on ClinicalTrials.gov

16. Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment

    This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT). The investigators will also assess barriers and facilitators to integrating MORE into methadone treatment, and eval…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT06032559 on ClinicalTrials.gov

17. rTMS as Add on Treatment for Substance Use Disorders

    This pilot study is designed to test feasibility and superiority of rTMS types and target locations for the optimal rTMS intervention for individuals seeking treatment for Alcohol Use Disorder (AUD) or Opioid Use Disorder (OUD). The critical questions this study seeks to answer are: which rTMS type…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Hartford Healthcare, Hartford, Connecticut

    Run by

    Yale University

    See if you can join NCT06963476 on ClinicalTrials.gov