Opioid Use Clinical Trials

42 studies are recruiting for opioid use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

   The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding moth…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Riley Children's Hospital- Clinics / Labor and Delivery Unit, Indianapolis, Indiana

   Locations

   4 in total

   Run by

   Senthil Sadhasivam

   See if you can join NCT05380531 on ClinicalTrials.gov

2. PRIDE III Prison Interventions and HIV Prevention Collaboration

   The primary objective of this research project is to identify barriers to scale-up of Opioid Agonist Therapy (OAT) in the justice systems (prisons and probation) in Tajikistan, Kyrgyzstan, Moldova, and Georgia, and establish a NIATx learning collaborative to scale-up OAT, and analyze scale-up utili…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Alternative Georgia, Tbilisi,

   Locations

   5 in total

   Run by

   Yale University

   See if you can join NCT06962033 on ClinicalTrials.gov

3. Hip Arthroscopy Postoperative Opioid Demands

   This study will be a prospective, single-blinded, randomized controlled trial (RCT), investigating the influence of the number of opioid pills prescribed following primary hip arthroscopy. All patients who sign the consent form will be enrolled in the suited and randomized to one of the two treatme…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT04094701 on ClinicalTrials.gov

4. fMRI and Opioid Abstinence

   This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Hartford Healthcare, Hartford, Connecticut

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT06651333 on ClinicalTrials.gov

5. Autonomic Neural Blockade in Bariatric Surgery

   The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants wil…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Endeavor Health, Evanston, Illinois

   Run by

   Endeavor Health

   See if you can join NCT07104825 on ClinicalTrials.gov

6. Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

   The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT04798469 on ClinicalTrials.gov

7. Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain

   The purpose of this research study is to see how a mindfulness meditation-based intervention affects pain. Specifically, we are interested in understanding the pain-relieving brain mechanisms of mindfulness meditation-based therapy for patients with opioid-treated chronic low back pain.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of California, San Diego, La Jolla, California

   Locations

   2 in total

   Run by

   University of Utah

   See if you can join NCT05607381 on ClinicalTrials.gov

8. Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

   The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco,…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06033599 on ClinicalTrials.gov

9. Sex Hormones, Postoperative Pain and Opioid Use

   Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors

   Stage

   Not phased

   Ages

   11 to 16

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06023225 on ClinicalTrials.gov

10. Opioid Dispensing Device for Post-Operative Pain in Cancer Patients

    This research study will evaluate the use of, and participants experience with, a new device called Addinex that safely stores and dispenses opioid medication. The purpose of this study is to evaluate the use of the Addinex device in cancer patients undergoing cancer-related surgery that require pa…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05585788 on ClinicalTrials.gov

11. QL vs LAI for Palatoplasty

    This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting). The patients will be randomized to receive either a unilateral QL block by an ane…

    Stage

    Not phased

    Ages

    6 to 18

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06420336 on ClinicalTrials.gov

12. Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects

    The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed buprenorphine. The main questions it aims to answer are: 1. What is the effect of…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VCU Institute for Drug and Alcohol Studies, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT06981195 on ClinicalTrials.gov

13. Sleep Disordered Breathing With Opioid Use

    There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to ide…

    Stage

    Phase 1

    Ages

    18 to 89

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT05589753 on ClinicalTrials.gov

14. Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City

    The sequential trial compares recovery and mHealth engagement outcomes among Black participants who participated in the mHealth intervention uMAT-R or uMAT-R + enhanced community engagement. The mHealth intervention seeks to support people in various stages of recovery who are also seeking other fo…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07673380 on ClinicalTrials.gov

15. Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention

    The goal of this treatment development project is to develop and pilot an adaptive mobile health (mHealth) intervention that targets the co-use of alcohol and opioids in young adults.

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT07663448 on ClinicalTrials.gov

16. Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

    The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction model as having an elevated risk for an opioid overdose. The clinical tr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT06806163 on ClinicalTrials.gov

17. Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

    This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Notre Dame, Notre Dame, Indiana

    Run by

    University of Notre Dame

    See if you can join NCT07342504 on ClinicalTrials.gov

18. Neuroimaging of Opioid Phase (OPAL)

    The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05905419 on ClinicalTrials.gov

19. Opioid Use After Laparoscopic Salpingectomy

    The purpose of this study is to evaluate patient-reported post-operative pain scores following minimally invasive tubal sterilization procedures to determine if a multimodal, non-opioid pain control regimen is non-inferior to a pain control regimen including opioids. The study team hypothesizes tha…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06434233 on ClinicalTrials.gov

20. Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

    The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery. The main questions are: 1. Do psycho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06466941 on ClinicalTrials.gov

21. Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

    The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical services (EMS) in Seattle, WA. Those transported to the SASC are the i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Downtown Emergency Service Center's Overdose Recovery and Care Access Centers, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06768814 on ClinicalTrials.gov

22. Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

    This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy. The study will examine post-operative opioid usage, length of stay, return to work, and patient reported outcomes following these procedures.

    Stage

    Phase 3

    Ages

    18 to 85

    Site

    Hospital for Special Surgery, New York, New York

    Run by

    Hospital for Special Surgery, New York

    See if you can join NCT05058287 on ClinicalTrials.gov

23. Post-Op Pain Control for Prophylactic Intramedullary Nailing.

    Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a uni…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Saint Louis University, St Louis, Missouri

    Run by

    St. Louis University

    See if you can join NCT03823534 on ClinicalTrials.gov

24. Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

    The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06345872 on ClinicalTrials.gov

25. Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

    An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Henry Ford Hospital System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT06113211 on ClinicalTrials.gov