Myasthenia Gravis Clinical Trials

24 studies are recruiting for myasthenia gravis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

   This study is part of the ADAPT Forward platform study (NCT07294170). ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects a…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Profound Research LLC - Carlsbad, Carlsbad, California

   Locations

   32 in total

   Run by

   argenx

   See if you can join NCT07284420 on ClinicalTrials.gov

2. ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

   ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Profound Research LLC - Carlsbad, Carlsbad, California

   Locations

   35 in total

   Run by

   argenx

   See if you can join NCT07294170 on ClinicalTrials.gov

3. Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

   The purpose of this study is to assess how well nipocalimab works when compared to efgartigimod in participants with generalized myasthenia gravis (a condition in which body's immune system mistakenly attacks and damages the connection between nerves and muscles causing muscle weakness).

   Stage

   Phase 3

   Ages

   18 to 74

   Site

   Neurology Center of North Orange County, Fullerton, California

   Locations

   17 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT07217587 on ClinicalTrials.gov

4. Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

   This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID) for 21 days.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California Irvine Medical Center, Irvine, California

   Locations

   40 in total

   Run by

   NMD Pharma A/S

   See if you can join NCT06414954 on ClinicalTrials.gov

5. A Study to Evaluate the Efficacy and Safety of Maintenance Ublituximab Following Induction With Efgartigimod Administration in Participants With Myasthenia Gravis (MG)

   The primary purpose of this study is to evaluate the efficacy of ublituximab in adult participants with MG responding to treatment with efgartigimod.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   TG Therapeutics Investigational Trial Site, Colorado Springs, Colorado

   Locations

   5 in total

   Run by

   TG Therapeutics, Inc.

   See if you can join NCT07673744 on ClinicalTrials.gov

6. AXIS MG Patient Registry

   The goal of the AXIS Autoimmune Neurology Registry is to learn about the experiences of adults living with autoimmune neurological disorders, starting with myasthenia gravis (MG), over time. The main questions the registry aims to answer are: * How do symptoms, daily functioning, and quality of lif…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Alira Health - Virtual/Remote Site - Can Be Completed 100% Online - All US Residents Accepted, Framingham, Massachusetts

   Run by

   Autoimmune Neurology Alliance

   See if you can join NCT07761026 on ClinicalTrials.gov

7. A Study Evaluating the Safety and Efficacy of KITE-363 in Relapsed/Refractory Autoimmune Neurologic Diseases

   This study will have two Phases: Phase 1a and Phase 1b. The goals of this clinical study are to learn more about the study drug KITE-363, by evaluating its safety, tolerability and efficacy in participants with relapsed/refractory autoimmune neurologic diseases. The primary objectives of this study…

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Hoag Memorial Hospital Presbyterian, Newport Beach, California

   Locations

   8 in total

   Run by

   Kite, A Gilead Company

   See if you can join NCT07304154 on ClinicalTrials.gov

8. Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

   PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally. Depending on their specific condition (MS, CIS, NMOSD, or other) and their specific treatment, pa…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   University of California-San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06940323 on ClinicalTrials.gov

9. MuSK Myasthenia 1000 Study

   The MuSK myasthenia gravis 1000 study seeks to collect saliva samples from 1000 subjects with laboratory confirmed diagnosis of MuSK myasthenia to identify genetic variations associated with MuSK MG. The data collected may be used by researchers to gain a better understanding of the cause of MuSK M…

   Stage

   Not phased

   Ages

   7 to 99

   Site

   George Washington University, Washington D.C., District of Columbia

   Run by

   George Washington University

   See if you can join NCT06259071 on ClinicalTrials.gov

10. A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

    The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to less than (<) 18 years of age (globally) and 8 to <18 years of age (for Unites Stated (US) sites only), the safety and tolerability of treatment with nipocalimab …

    Stage

    Phase 2

    Ages

    2 to 17

    Site

    Phoenix Children's Hospital, Phoenix, Arizona

    Locations

    19 in total

    Run by

    Janssen Research & Development, LLC

    See if you can join NCT05265273 on ClinicalTrials.gov

11. KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

    A Study of the Anti-CD 19 Chimeric Antigen Receptor T Cell Therapy for Patients with Myasthenia Gravis

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Ronald Reagan UCLA Medical Center, Los Angeles, California

    Locations

    22 in total

    Run by

    Kyverna Therapeutics

    See if you can join NCT06193889 on ClinicalTrials.gov

12. A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

    The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravis (gMG). The purpose of the subcutaneous substudy is to evaluate how well it works in the body (pharmacodynamic [PD]) when given as an injection under…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Neuromuscular Research Center and Clinic, Paradise Valley, Arizona

    Locations

    112 in total

    Run by

    Janssen Research & Development, LLC

    See if you can join NCT04951622 on ClinicalTrials.gov

13. Light vs. Moderate Intensity Exercise in Individuals With Myasthenia Gravis

    The overall purpose of this pilot study is to examine the feasibility, acceptability, and tolerability of light and moderate intensity exercise in adults with MGeffect of light vs. moderate intensity exercise on health outcomes. Participants will be enrolled into the NeuroWell exercise program, whi…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    HealthPartners Neuroscience Center, Saint Paul, Minnesota

    Run by

    HealthPartners Institute

    See if you can join NCT06491238 on ClinicalTrials.gov

14. Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

    This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses …

    Stage

    Not phased

    Ages

    18 and older

    Site

    NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07478172 on ClinicalTrials.gov

15. A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

    A Phase 1 dose-escalation study designed to evaluate the safety, tolerability, and preliminary efficacy of anito-cel in subjects with generalized myasthenia gravis (GMG). Anitocabtagene autoleucel (anito-cel) is a BCMA-directed CAR-T cell therapy.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UCLA Medical Center, Los Angeles, California

    Locations

    13 in total

    Run by

    Arcellx, Inc.

    See if you can join NCT06626919 on ClinicalTrials.gov

16. A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

    This is a non-interventional, prospective, post authorization safety study. Patients with gMG who are expected to start treatment with efgartigimod at enrolment or are within their first cycle of efgartigimod at enrolment will be eligible to enroll into the efgartigimod cohort. Patients with gMG wh…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCSF Medical Center - Helen Diller Family Comprehensive Cancer Center - Brain Tumor Center,, San Francisco, California

    Locations

    35 in total

    Run by

    argenx

    See if you can join NCT06298565 on ClinicalTrials.gov

17. A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to Efgartigimod During Pregnancy and/or Breastfeeding.

    This is a multi-country, prospective safety study of pregnant women exposed to efgartigimod or efgartigimod PH20 SC any time within 25 days prior to conception or any time during pregnancy. Women exposed to efgartigimod or efgartigimod PH20 SC only during breastfeeding will also be eligible to enro…

    Stage

    Not phased

    Ages

    Any age

    Site

    United BioSource LLC, Morgantown, West Virginia

    Locations

    4 in total

    Run by

    argenx

    See if you can join NCT06299748 on ClinicalTrials.gov

18. A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis

    The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of IM-101 in adult participants with AChR antibody-positive gMG. Subsequently, the safety and efficacy of the selected IM-101 dose-regimen will be tested in pa…

    Stage

    Phase 1

    Ages

    18 to 74

    Site

    Neurology of Central Florida Research Center, LLC, Altamonte Springs, Florida

    Locations

    25 in total

    Run by

    ImmunAbs Inc.

    See if you can join NCT07250750 on ClinicalTrials.gov

19. The EXPLORE MG Registry for Myasthenia Gravis

    The purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale-New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT03792659 on ClinicalTrials.gov

20. Vitaccess Real MG Registry

    Vitaccess Real MG (VRMG) is a patient registry designed to capture longitudinal observational data on myasthenia gravis (MG), its treatment, and impact on symptoms, daily activities, and quality of life (QoL). The duration of the registry is 10 years from launch, and approximately 600 patients will…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCI Health, Orange, California

    Locations

    8 in total

    Run by

    Vitaccess Ltd

    See if you can join NCT06064461 on ClinicalTrials.gov

21. Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

    CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help …

    Stage

    Not phased

    Ages

    Any age

    Site

    Sanford Health, Sioux Falls, South Dakota

    Locations

    2 in total

    Run by

    Sanford Health

    See if you can join NCT01793168 on ClinicalTrials.gov

22. The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

    ME\&MG is a standalone software (digital solution) running on patients smartphones, connected to a web portal for physicians. It is intended to be used as an unsupervised digital self-assessment tool for the monitoring of disabilities in patients living with MG. ME\&MG contains digital active tests…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Colorado Denver, Aurora, Colorado

    Locations

    19 in total

    Run by

    Ad scientiam

    See if you can join NCT05564936 on ClinicalTrials.gov

23. Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment

    This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The primary objective is to determine the validity of a self-as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    ZS Associates, Evanston, Illinois

    Run by

    ZS Associates

    See if you can join NCT06866483 on ClinicalTrials.gov

24. Myasthenia Gravis Foundation of America Global MG Patient Registry

    The goal of this observational study is to learn about the experiences of people living with Myasthenia Gravis (MG) in the United States. The main questions it aims to answer are: * How and when are people with MG diagnosed? * What are the most common symptoms associated with MG? * What treatments …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Myasthenia Gravis Foundation of America, Westborough, Massachusetts

    Run by

    Myasthenia Gravis Foundation of America

    See if you can join NCT06617741 on ClinicalTrials.gov