Multiple System Atrophy Clinical Trials in Nashville, Tennessee

7 studies are recruiting for multiple system atrophy in Nashville, Tennessee right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

   The primary objective of the study is to evaluate the efficacy of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA). A secondary objective of the study is to evaluate specific efficacy parameters of TEV-56286. Another secondary objective is to …

   Stage

   Phase 2

   Ages

   30 to 75

   Site

   Teva Investigational Site 15874, Nashville, Tennessee

   Locations

   61 in total

   Run by

   Teva Branded Pharmaceutical Products R&D LLC

   See if you can join NCT06568237 on ClinicalTrials.gov

2. Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

   The objective of this study is to find a more objective and accurate way to assess the efficacy of the treatment for neurogenic orthostatic hypotension. For this purpose, the investigators will use an activity monitor to determine the amount of time patients spend in the upright position (standing …

   Stage

   Not phased

   Ages

   40 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT04782830 on ClinicalTrials.gov

3. Natural History Study of Synucleinopathies

   Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of moveme…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Vanderbilt Univeristy, Nashville, Tennessee

   Locations

   8 in total

   Run by

   NYU Langone Health

   See if you can join NCT01799915 on ClinicalTrials.gov

4. CPAP for the Treatment of Supine Hypertension

   This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment f…

   Stage

   Not phased

   Ages

   40 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05489575 on ClinicalTrials.gov

5. [18F]F-DOPA Imaging in Patients With Autonomic Failure

   Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-synuclein inclusions (Lewy Bodies) and the pattern of progressive neuronal death (e.g. caudal to rost…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Daniel Claassen

   See if you can join NCT04246437 on ClinicalTrials.gov

6. Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

   Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hyp…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT03042988 on ClinicalTrials.gov

7. Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

   The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt Univ…

   Stage

   Phase 1

   Ages

   40 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT02897063 on ClinicalTrials.gov