Multiple System Atrophy Clinical Trials

15 studies are recruiting for multiple system atrophy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

   The primary objective of the trial is to describe the long-term safety and tolerability of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA). A secondary objective of the trial is to further describe the safety and tolerability of TEV-56286. Th…

   Stage

   Phase 2

   Ages

   30 and older

   Site

   Teva Investigational Site 15554, La Jolla, California

   Locations

   36 in total

   Run by

   Teva Branded Pharmaceutical Products R&D LLC

   See if you can join NCT07197866 on ClinicalTrials.gov

2. Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

   This phase I double-blind study focuses on the safety and feasibility of implanting autologous peripheral nerve tissue (PNT) into the substantia nigra area of the brain in persons who have been diagnosed with either Parkinson's disease (PD) or Multiple System Atrophy (MSA). 7 participants will be e…

   Stage

   Phase 1

   Ages

   40 to 75

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Craig van Horne, MD, PhD

   See if you can join NCT06683365 on ClinicalTrials.gov

3. A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

   The primary objective of the study is to evaluate the efficacy of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA). A secondary objective of the study is to evaluate specific efficacy parameters of TEV-56286. Another secondary objective is to …

   Stage

   Phase 2

   Ages

   30 to 75

   Site

   Teva Investigational Site 15554, La Jolla, California

   Locations

   61 in total

   Run by

   Teva Branded Pharmaceutical Products R&D LLC

   See if you can join NCT06568237 on ClinicalTrials.gov

4. Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

   The objective of this study is to find a more objective and accurate way to assess the efficacy of the treatment for neurogenic orthostatic hypotension. For this purpose, the investigators will use an activity monitor to determine the amount of time patients spend in the upright position (standing …

   Stage

   Not phased

   Ages

   40 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT04782830 on ClinicalTrials.gov

5. Natural History Study of Synucleinopathies

   Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of moveme…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Locations

   8 in total

   Run by

   NYU Langone Health

   See if you can join NCT01799915 on ClinicalTrials.gov

6. A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

   A Phase 2a Study of Foralumab Nasal in Patients with Multiple System Atrophy (MSA)

   Stage

   Phase 2

   Ages

   30 to 85

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Tiziana Life Sciences LTD

   See if you can join NCT06868628 on ClinicalTrials.gov

7. CPAP for the Treatment of Supine Hypertension

   This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment f…

   Stage

   Not phased

   Ages

   40 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05489575 on ClinicalTrials.gov

8. [18F]F-DOPA Imaging in Patients With Autonomic Failure

   Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-synuclein inclusions (Lewy Bodies) and the pattern of progressive neuronal death (e.g. caudal to rost…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Daniel Claassen

   See if you can join NCT04246437 on ClinicalTrials.gov

9. Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

   The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.

   Stage

   Not phased

   Ages

   Any age

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT03872102 on ClinicalTrials.gov

10. Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

    Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hyp…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT03042988 on ClinicalTrials.gov

11. The CurePSP Genetics Program

    This study is an observational, prospective genetic study. It aims to obtain DNA for research and testing from patients with PSP, CBS, MSA, and related neurological conditions and their families. Up to 1,000 adults who have been clinically diagnosed with PSP, CBS, MSA, or related neurological condi…

    Stage

    Not phased

    Ages

    35 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06647641 on ClinicalTrials.gov

12. PET Imaging Evaluation of [11C]SY08

    The overall goal of the proposed research is to evaluate the use of [11C]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with Lewy Bodies (DLB) and healthy controls. The purpose of this study is to e…

    Stage

    EARLY_Phase 1

    Ages

    50 to 80

    Site

    MGH, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06098612 on ClinicalTrials.gov

13. Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

    The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt Univ…

    Stage

    Phase 1

    Ages

    40 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT02897063 on ClinicalTrials.gov

14. Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

    CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help …

    Stage

    Not phased

    Ages

    Any age

    Site

    Sanford Health, Sioux Falls, South Dakota

    Locations

    2 in total

    Run by

    Sanford Health

    See if you can join NCT01793168 on ClinicalTrials.gov

15. NYSCF Scientific Discovery Biobank

    The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store th…

    Stage

    Not phased

    Ages

    0 and older

    Site

    New York Stem Cell Foundation Research Institute, New York, New York

    Run by

    New York Stem Cell Foundation Research Institute

    See if you can join NCT06203106 on ClinicalTrials.gov