Multiple Sclerosis Clinical Trials

109 studies are recruiting for multiple sclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 13 Chicago, Illinois 13 New York, New York 13 Bethesda, Maryland 9 Cleveland, Ohio 7 Baltimore, Maryland 6 St Louis, Missouri 6 Aurora, Colorado 5 Birmingham, Alabama 5 Houston, Texas 5 Kansas City, Kansas 5 San Francisco, California 5 Atlanta, Georgia 4 Austin, Texas 4 Dallas, Texas 4 Seattle, Washington 4 Columbus, Ohio 3 East Hanover, New Jersey 3 Miami, Florida 3 Milwaukee, Wisconsin 3 Palo Alto, California 3 Pittsburgh, Pennsylvania 3 Salt Lake City, Utah 3 Urbana, Illinois 3 Washington D.C., District of Columbia 3

Studies, page 4

  1. Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

    In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neur…

    Stage
    Not phased
    Ages
    7 and older
    Site
    University of Pittsburgh, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT02994121 on ClinicalTrials.gov

  2. Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS

    The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton device (Ekso-GT), to improve learning and memory, and gait therapy in persons with walking disability due to Multiple Sclerosis. The study will evaluate the mobility, learning and memory, and walking …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Kessler Foundation, West Orange, New Jersey
    Run by
    Kessler Foundation

    See if you can join NCT04855825 on ClinicalTrials.gov

  3. Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)

    The goal of the study is to learn about treating older people with multiple sclerosis (MS) with metformin. Metformin may be used as a single therapy or as an add-on therapy. The investigators want to learn: * The safety and tolerability of metformin extended release (1500 mg/day) as a single therap…

    Stage
    Phase 2
    Ages
    55 to 75
    Site
    UBMD Neurolgy, Buffalo, New York
    Run by
    State University of New York at Buffalo

    See if you can join NCT06463743 on ClinicalTrials.gov

  4. A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring

    The purpose of this study is to provide information on maternal, fetal, and infant outcomes following exposure of ozanimod during pregnancy so that participants and physicians can weigh the benefits and risks of exposure to the pharmaceutical during pregnancy and make informed treatment decisions.

    Stage
    Not phased
    Ages
    Any age
    Site
    Evidera INC., Bethesda, Maryland
    Locations
    3 in total
    Run by
    Bristol-Myers Squibb

    See if you can join NCT05170126 on ClinicalTrials.gov

  5. NARCOMS Registry: A Multiple Sclerosis Registry

    This project is based on the idea that we can learn about the complexities of MS by following disease and treatment patterns in a large group of people over several years. The information gathered is used for research only. Results are presented in summary form only. All details submitted by regist…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UT Southwestern Medical Center, Dallas, Texas
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT01018537 on ClinicalTrials.gov

  6. Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?

    People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has show…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Health, Medical and Neuropsychology, Institute of Psychology, Faculty of Behvavioural and Social Siences, Leiden University, Leiden,
    Locations
    3 in total
    Run by
    Universiteit Leiden

    See if you can join NCT07225868 on ClinicalTrials.gov

  7. "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS

    The goal of this observational study is to validate a novel, cost-effective method for real-world assessment using patient-acquired "selfie" videos in people with multiple sclerosis. The investigators aim to prove the feasibility and validity of monitoring walking changes remotely through a truly p…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California, San Francisco, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07222618 on ClinicalTrials.gov

  8. HOBSCOTCH-MS-Efficacy Trial

    The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also ass…

    Stage
    Not phased
    Ages
    20 to 75
    Site
    Dartmouth-Health Lebanon, Lebanon, New Hampshire
    Run by
    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06951919 on ClinicalTrials.gov

  9. A Study of the MIND Diet for Persons With Multiple Sclerosis

    This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Mount Sinai Hospital, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06992115 on ClinicalTrials.gov

  10. Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

    The objective of this RCT is to assess the efficacy of one-on-one telehealth CBT-I (tCBT-I) compared to web-based CBT-I (wCBT-I) and treatment as usual (TAU) to improve sleep outcomes (Aim 1), fatigue and quality of life (Aim 2), and promote neuroprotection (Exploratory Aim 3), and to explore the c…

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    University of Kansas Medical Center- Sleep, Health and Wellness Laboratory, Kansas City, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT06434571 on ClinicalTrials.gov

  11. Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

    The purpose of this research is to support the clinical value of the Cionic Neural Sleeve for individuals diagnosed with multiple sclerosis (MS).

    Stage
    Not phased
    Ages
    22 to 75
    Site
    Cleveland State University, Cleveland, Ohio
    Run by
    Cionic, Inc.

    See if you can join NCT05964829 on ClinicalTrials.gov

  12. Vancomycin Study in Multiple Sclerosis (MS)

    The overall goal of this study is to elucidate a mechanism by which vancomycin modulates the gut-brain axis in multiple sclerosis (MS). The gut microbiome plays an important role in autoimmunity, including MS. However, the identity of gut microbes modulating neuroinflammation in MS and their mechan…

    Stage
    Phase 1
    Ages
    18 to 50
    Site
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05539729 on ClinicalTrials.gov

  13. An Individualized-health eLibrary App for People With Multiple Sclerosis

    The purpose of this study is to assess the effectiveness after using a new individualized-health e-library app named SavvyHealth among people with multiple sclerosis.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Illinois Urbana-Champaign, Champaign, Illinois
    Run by
    University of Illinois at Urbana-Champaign

    See if you can join NCT05124600 on ClinicalTrials.gov

  14. Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

    The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UMass Boston, Boston, Massachusetts
    Run by
    University of Massachusetts, Boston

    See if you can join NCT06554340 on ClinicalTrials.gov

  15. AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis

    The UAB Institute for Arts In Medicine (AIM) is currently implementing an expressive emotional writing pilot project for adults with paralysis caused by neurological conditions such as traumatic head or spinal cord injury.

    Stage
    Not phased
    Ages
    18 and older
    Site
    354 School of Health Professions Building, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT04721717 on ClinicalTrials.gov

  16. Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis

    The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosi…

    Stage
    Not phased
    Ages
    18 to 89
    Site
    Emory Univeristy, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT06495138 on ClinicalTrials.gov

  17. Dry Needling in Multiple Sclerosis

    The investigators are doing this study to see if a treatment called dry needling improves muscle spasticity (muscle tightness) in people who have Multiple Sclerosis. Dry needling involves using tiny needles, like those in acupuncture, to target some muscles, like calf muscles. It differs from tradi…

    Stage
    Not phased
    Ages
    18 to 64
    Site
    Mobility and Falls Lab, Kansas City, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT06394310 on ClinicalTrials.gov

  18. Effects of Torso Weighting on Muscle Activation During Balance Tests in Individuals With and Without Multiple Sclerosis

    Rationale: The Balance-Based Torso-Weighting (BBTW) is a patented evaluation system that uses strategic placement of small or lightweight weights on the trunk to improve balance and stability. BBTW has been found to improve the upright mobility of people with multiple sclerosis, however the mechani…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    University of St. Augustine for Health Sciences, Saint Augustine, Florida
    Run by
    University of St. Augustine for Health Sciences

    See if you can join NCT06981013 on ClinicalTrials.gov

  19. NYSCF Scientific Discovery Biobank

    The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store th…

    Stage
    Not phased
    Ages
    0 and older
    Site
    New York Stem Cell Foundation Research Institute, New York, New York
    Run by
    New York Stem Cell Foundation Research Institute

    See if you can join NCT06203106 on ClinicalTrials.gov

  20. Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

    Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: * Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administration o…

    Stage
    Phase 1
    Ages
    18 to 65
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT04699747 on ClinicalTrials.gov

  21. Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community

    Cognitive impairments are common in multiple sclerosis (MS) diagnosed both at the onset and throughout the disease course. Poor cognitive abilities have been associated with poor outcomes such as higher levels of unemployment, poor quality of life, driving difficulties among others. Learning and me…

    Stage
    Not phased
    Ages
    19 to 65
    Site
    Kessler Foundation, East Hanover, New Jersey
    Run by
    Kessler Foundation

    See if you can join NCT06608797 on ClinicalTrials.gov

  22. IConquerMS™ - a Patient-Powered Research Network for Multiple Sclerosis

    iConquerMS™ is a research initiative developed by and for people with multiple sclerosis (MS) to contribute their health data and ideas to advance and accelerate research into MS. iConquerMS welcomes adults with MS and others interested in advancing MS research, children and teens with MS and their…

    Stage
    Not phased
    Ages
    Any age
    Site
    Accelerated Cure Project, Waltham, Massachusetts
    Run by
    Accelerated Cure Project for Multiple Sclerosis

    See if you can join NCT02486562 on ClinicalTrials.gov

  23. Kesimpta (Ofatumumab) Pregnancy Registry

    The Kesimpta Pregnancy Registry is an observational, exposure cohort designed study to examine pregnancy and infant outcomes in women and infants who are exposed to Kesimpta (ofatumumab) during pregnancy to treat MS.

    Stage
    Not phased
    Ages
    18 to 100
    Site
    University of California San Diego OTIS, La Jolla, California
    Run by
    Novartis Pharmaceuticals

    See if you can join NCT05634967 on ClinicalTrials.gov

  24. Entire-body PET Scans for Multiple Sclerosis

    To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.

    Stage
    EARLY_Phase 1
    Ages
    25 to 55
    Site
    Brain Health Alliance, Ladera Ranch, California
    Run by
    Brain Health Alliance

    See if you can join NCT04390009 on ClinicalTrials.gov

  25. Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS

    The objective of the randomized, sham-controlled trial will be to evaluate the effectiveness of treatment with transcutaneous electrical nerve stimulation (TENS) at reducing the level of fatigue experienced by people with MS.

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of Colorado, Boulder, Colorado
    Run by
    University of Colorado, Boulder

    See if you can join NCT05500963 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.