Movement Disorders Clinical Trials

17 studies are recruiting for movement disorders in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Boston, Massachusetts 6 Philadelphia, Pennsylvania 3

Studies now recruiting

  1. Botulinum Toxin for the Treatment of Involuntary Movement Disorders

    BTX has been used since the 1980s in support of the research mission of NINDS. Initial studies were focused on expanding the applicability of BTX treatment to movement disorders and exploring new indications. We evaluated the efficacy of an alternative serotype, type F. Under other protocols, we co…

    Stage
    Not phased
    Ages
    2 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT00001208 on ClinicalTrials.gov

  2. Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

    Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investig…

    Stage
    Not phased
    Ages
    40 and older
    Site
    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia
    Run by
    VA Office of Research and Development

    See if you can join NCT06088355 on ClinicalTrials.gov

  3. Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

    The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement di…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Pennsylvania Hospital, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT06848530 on ClinicalTrials.gov

  4. Cognitive Decline Following Deep Brain Stimulation

    This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will b…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT05822388 on ClinicalTrials.gov

  5. Validating a New Machine-Learned Accelerometer Algorithm Using Doubly Labeled Water

    The purpose of this study is to validate previously developed physical function-clustered specific machine-learned accelerometer algorithms to estimate total daily energy expenditure (TDEE) in individuals with general movement and functional limitations.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
    Run by
    University of Wisconsin, Milwaukee

    See if you can join NCT05736302 on ClinicalTrials.gov

  6. Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    The University of Texas at Austin, Austin, Texas
    Run by
    University of Texas at Austin

    See if you can join NCT05183152 on ClinicalTrials.gov

  7. A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

    This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.

    Stage
    Not phased
    Ages
    30 to 99
    Site
    University of Maryland, Baltimore, Baltimore, Maryland
    Locations
    5 in total
    Run by
    InSightec

    See if you can join NCT05539196 on ClinicalTrials.gov

  8. Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

    The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80 inherited neurological diseases that share the common feature of progressive spasticity. Collectively, the HSP…

    Stage
    Not phased
    Ages
    0 to 30
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT05354622 on ClinicalTrials.gov

  9. A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

    The Epilepsy-Dyskinesia Study aims to advance the understanding of the clinical and molecular spectrum of epilepsy-dyskinesia syndromes, monogenic diseases that cause both movement disorders and epilepsy. Addressing challenges in rare disease research -such as small, geographically dispersed patien…

    Stage
    Not phased
    Ages
    0 to 18
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06585605 on ClinicalTrials.gov

  10. A Multicenter Pediatric Deep Brain Stimulation Registry

    There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies adequately. This study aims to develop a multicenter pediatric DBS registry tha…

    Stage
    Not phased
    Ages
    0 to 18
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06585618 on ClinicalTrials.gov

  11. Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

    The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These movement disorders commonly have significant non-motor features, such as depression, cognitive and memory…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT04061135 on ClinicalTrials.gov

  12. Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

    The purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders. The study investigates the effects of wearing the device during a set of experiments including leg stretching…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Syracuse VA Medical Center, Syracuse, NY, Syracuse, New York
    Run by
    VA Office of Research and Development

    See if you can join NCT05926596 on ClinicalTrials.gov

  13. Abbott DBS Post-Market Study of Outcomes for Indications Over Time

    The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

    Stage
    Not phased
    Ages
    Any age
    Site
    University of South Florida - Department of Neurology, Tampa, Florida
    Locations
    48 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT04071847 on ClinicalTrials.gov

  14. Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants

    Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG), electromyography (EMG), functional near infrared spectroscopy (fNIRS), inertial meas…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UCLA Neural Engineering and Computation Lab, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT07236892 on ClinicalTrials.gov

  15. Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

    The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information that are made available to the research community. To accomplish these goals, we will enroll 800 Am…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Barrow Neurological Institute, Phoenix, Arizona
    Locations
    12 in total
    Run by
    Target ALS Foundation, Inc.

    See if you can join NCT05137665 on ClinicalTrials.gov

  16. Registry and Natural History of Epilepsy-Dyskinesia Syndromes

    The Registry and Natural History of Epilepsy-Dyskinesia Syndromes is focused on gathering longitudinal clinical data as well as biological samples (blood, urine, and/or skin/tissue) from male and female patients, of all ages, who have a genetic diagnosis of epilepsy-dyskinesia syndromes. Through pr…

    Stage
    Not phased
    Ages
    0 to 30
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06967727 on ClinicalTrials.gov

  17. Analysis of Human Movement With Assistive Devices

    The purpose of this research is to evaluate how people move about in different settings with different assistive devices or components, and to understand how people interact with different assistive technologies. Individuals that have limb weakness, limb paralysis, limb loss, and movement disorders…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    Orthocare Innovations, LLC, Edmonds, Washington
    Run by
    Orthocare Innovations, LLC

    See if you can join NCT05729061 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.