Mitral Regurgitation Clinical Trials

16 studies are recruiting for mitral regurgitation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Cephea Early Feasibility Study

   The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Banner-University Medical Center Phoenix, Phoenix, Arizona

   Locations

   22 in total

   Run by

   Abbott Medical Devices

   See if you can join NCT05061004 on ClinicalTrials.gov

2. Abbott Cephea Mitral Valve Disease Registry

   The objective of this registry is to gather clinical data on symptomatic patients with mitral valve disease, including patients with mitral regurgitation, mitral stenosis, and mixed mitral valve disease. Data collected from this registry are expected to improve our understanding of the impact of co…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama

   Locations

   24 in total

   Run by

   Abbott Medical Devices

   See if you can join NCT07069673 on ClinicalTrials.gov

3. EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States)

   The goal of this early feasibility clinical trial is to learn if the device MR-ace Implant and Delivery System works in patients with moderate or severe mitral valve regurgitation. It will also learn about the safety of the device MR-ace Implant and Delivery System. The main questions it aims to an…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Emory Midtown, Atlanta, Georgia

   Locations

   3 in total

   Run by

   Polares Medical SA

   See if you can join NCT07517588 on ClinicalTrials.gov

4. Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

   CASSINI-US is a prospective, single-arm, multicenter early feasibility study enrolling up to 15 patients at up to 5 sites in the United States (US). The purpose of the study is to evaluate the technical (implant) feasibility, and safety, and performance of the SATURN TS TMVR System for the treatmen…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Los Robles Regional Medical Center, Thousand Oaks, California

   Locations

   5 in total

   Run by

   InnovHeart

   See if you can join NCT07130994 on ClinicalTrials.gov

5. ATLAS (AltaValve) Pivotal Trial

   This is a prospective, single arm, multicenter, clinical trial designed to evaluate the safety and performance of the AltaValve System for the treatment of mitral regurgitation in a targeted patient population.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Banner University Medical Center, Phoenix, Arizona

   Locations

   58 in total

   Run by

   4C Medical Technologies, Inc.

   See if you can join NCT06465745 on ClinicalTrials.gov

6. The CardioClip Study

   The CardioClip study is exploring the use of a wireless sensor to monitor pressure in the pulmonary artery. This sensor is inserted much like the mTEER procedure, a non-surgical method through a vein in the groin. The investigators want to find out if the sensor, by constantly sending information a…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Columbia University Irving Medical Center / NewYork-Presbyterian Hospital, New York, New York

   Run by

   Columbia University

   See if you can join NCT06241430 on ClinicalTrials.gov

7. Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

   ARB-PMCF is a multicenter, observational study of the safety and performance of Abbott annuloplasty devices used in surgical repair of mitral and tricuspid valve regurgitation. The devices included in this study are the SJM™ Rigid Saddle Ring and SJM Séguin Annuloplasty Ring, indicated for mitral v…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tartu University Hospital, Tartu,

   Locations

   17 in total

   Run by

   Abbott Medical Devices

   See if you can join NCT04761120 on ClinicalTrials.gov

8. CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

   This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice. Patients evaluated for TMVR but not undergoin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tucson Medical Center, Tucson, Arizona

   Locations

   43 in total

   Run by

   Universitätsklinikum Hamburg-Eppendorf

   See if you can join NCT04688190 on ClinicalTrials.gov

9. Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

   Mitral regurgitation may be seen in the setting of cardiogenic shock. Transcatheter edge-to-edge repair (TEER) has been shown to improve outcomes in patients with chronic heart failure. Observational studies suggest improvements in clinical outcomes in patients with mitral regurgitation in the sett…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Locations

   4 in total

   Run by

   Ottawa Heart Institute Research Corporation

   See if you can join NCT05298124 on ClinicalTrials.gov

10. A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

    To confirm the effectiveness and safety of the GeminiOne Transcatheter Mitral Valve Repair System for the treatment of severe, symptomatic mitral regurgitation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Los Robles Regional Medical Centre, Thousand Oaks, California

    Run by

    Sierra Valve LLC

    See if you can join NCT07086534 on ClinicalTrials.gov

11. The ENCIRCLE Trial

    This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable. Following completion of enrollment, subjects will be …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Laval University, Québec, Quebec

    Locations

    68 in total

    Run by

    Edwards Lifesciences

    See if you can join NCT04153292 on ClinicalTrials.gov

12. EFS of the CardioMech MVRS

    Safety and performance evaluation of the CardioMech Mitral Valve Repair System (MVRS) in patients with degenerative mitral valve regurgitation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University, Evanston, Illinois

    Locations

    12 in total

    Run by

    CardioMech AS

    See if you can join NCT04820764 on ClinicalTrials.gov

13. The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

    A prospective multicenter study enrolling high surgical risk patients with severe mitral annular calcification (MAC) and symptomatic mitral valve dysfunction (severe stenosis, ≥ moderate to severe regurgitation, or mixed ≥ moderate stenosis and ≥ regurgitation). There are 2 Arms in this study: 1) "…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dignity Health Chandler Regional Medical Center, Gilbert, Arizona

    Locations

    17 in total

    Run by

    Mayra Guerrero

    See if you can join NCT04408430 on ClinicalTrials.gov

14. Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

    This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is t…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06780241 on ClinicalTrials.gov

15. Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

    The study proposes to develop a phenylephrine protocol to be used during transesophageal echocardiography, whereby intravenous phenylephrine would be used to increase afterload with the intent to mimic the awake hemodynamic profile and variation that occurs with normal physical activity. The expect…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Montefiore Medical Center, New York, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT04500899 on ClinicalTrials.gov

16. An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

    Study to evaluate the feasibility, safety and performance of the HighLife trans-septal Transcatheter Mitral Valve in patients with moderate-severe and severe mitral regurgitation who are at high risk for surgical treatment.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tucson Medical Center, Tucson, Arizona

    Locations

    10 in total

    Run by

    HighLife SAS

    See if you can join NCT04029337 on ClinicalTrials.gov