Mild Traumatic Brain Injury Clinical Trials

30 studies are recruiting for mild traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

   This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

   Stage

   Not phased

   Ages

   30 to 90

   Site

   VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

   Run by

   VA Office of Research and Development

   See if you can join NCT04124029 on ClinicalTrials.gov

2. Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

   This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mi…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07246993 on ClinicalTrials.gov

3. Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

   This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those…

   Stage

   Phase 2

   Ages

   55 and older

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT05446584 on ClinicalTrials.gov

4. Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

   The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI).

   Stage

   Phase 3

   Ages

   21 to 55

   Site

   Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

   Locations

   16 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04867317 on ClinicalTrials.gov

5. Risk Stratification in Children With Concussion

   This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children at higher risk for persistent postconcussive symptoms. Findings will pr…

   Stage

   Not phased

   Ages

   11 to 17

   Site

   Duke University Health System, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT05825027 on ClinicalTrials.gov

6. Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

   The purpose of the study is to test two different training programs to find out which is better at helping people with a concussion or mild TBI (mTBI) improve their emotional health and well-being. Study participation is completely remote and will last approximately 8 months total, involving 4 asse…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Indiana University, Indianapolis, Indiana

   Locations

   3 in total

   Run by

   Hackensack Meridian Health

   See if you can join NCT07436754 on ClinicalTrials.gov

7. Facilitating Access to Specialty Treatment

   The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention, designed to reduce disparities in access to specialty care through the u…

   Stage

   Not phased

   Ages

   13 to 18

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT05741411 on ClinicalTrials.gov

8. Neuromodulation and Neurorehabilitation for mTBI

   This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) dete…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Northwestern University, Chicago, Illinois

   Locations

   2 in total

   Run by

   Northwestern University

   See if you can join NCT03819608 on ClinicalTrials.gov

9. Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

   The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent…

   Stage

   Not phased

   Ages

   20 to 85

   Site

   University of Wisconsin - Madison, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07044596 on ClinicalTrials.gov

10. Recovery Among Older Adults Following Mild TBI

    Among fall related injuries in older adults, head injuries are the most common, yet almost nothing is known about recovery from head injury, also known as traumatic brain injury or TBI, in this population. The RETRO-TBI study is a prospective cohort study of 250 adults aged 65 and older with mild T…

    Stage

    Not phased

    Ages

    65 and older

    Site

    University of Maryland, Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT07569354 on ClinicalTrials.gov

11. Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

    The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    UCSD, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT05682677 on ClinicalTrials.gov

12. Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)

    This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances. The research aims to evaluate the effects of CBT-I on sleep, mTBI symptoms, and, in particular, the ability of individuals with mTBI …

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Missouri-Columbia, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07385105 on ClinicalTrials.gov

13. rTMS for Military TBI-related Depression

    The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a his…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Locations

    3 in total

    Run by

    Henry M. Jackson Foundation for the Advancement of Military Medicine

    See if you can join NCT05426967 on ClinicalTrials.gov

14. Improving Cognitive Rehabilitation Outcomes

    Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality of life, and treatment response than either condition alone. Addition…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07055633 on ClinicalTrials.gov

15. Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury

    The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI). These conditions have been shown to be linked. The investigators are using a hig…

    Stage

    Phase 1

    Ages

    22 to 65

    Site

    Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois

    Run by

    VA Office of Research and Development

    See if you can join NCT05647044 on ClinicalTrials.gov

16. Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

    The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that oc…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    UCLA, Westwood, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06073886 on ClinicalTrials.gov

17. Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury

    Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations. We are testing a brain stimulation method along with evaluating objective tools to help record and restore communication among affected brain areas, which will fa…

    Stage

    Not phased

    Ages

    10 to 15

    Site

    Ghazala Saleem, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT05762796 on ClinicalTrials.gov

18. Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury

    Mild traumatic brain injury (mTBI) poses a substantial clinical and public health burden, often leading to persistent neurosensory and cognitive symptoms for which diagnostic and therapeutic solutions remain limited. This study proposes a multimodal diagnostic framework that integrates established …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami Miller School of Medicine - Don Soffer Clinical Research Building, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT07356167 on ClinicalTrials.gov

19. Behavioral Insomnia Treatment in Mild Traumatic Brain Injury

    This is a single site, two-armed random controlled trials (RCT) comparing six sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) with four sessions of Brief Behavioral Therapy for Insomnia (BBT-I) in service members with comorbid insomnia and prolonged postconcussive symptoms present for…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Carl R. Darnall Army Medical Center, Fort Cavazos, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06551987 on ClinicalTrials.gov

20. Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI

    The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury (mTBI). The main question is whether participants who use the digital format…

    Stage

    Not phased

    Ages

    18 and older

    Site

    James A Haley VA Hospital, Tampa, Florida

    Locations

    3 in total

    Run by

    Mountain Home Research & Education Corporation

    See if you can join NCT06222450 on ClinicalTrials.gov

21. Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

    The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

    Run by

    VA Office of Research and Development

    See if you can join NCT06109909 on ClinicalTrials.gov

22. Auditory Plasticity Training

    The investigators are working on a project to help people who have had mild brain injuries hear better. Sometimes, these injuries can make it hard for people to hear clearly, especially in noisy places or when trying to tell where sounds are coming from. The project is testing special training exer…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    The University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06628505 on ClinicalTrials.gov

23. Concussion Recovery and Support Program

    Pilot randomized controlled trial (RCT) comparing a novel intervention Concussion Recovery and Support Program (CRISP) for adolescents and young adults (AYA) 18-29 yo with concussion/ mild TBI.

    Stage

    Not phased

    Ages

    18 to 29

    Site

    Seattle Children's Research Institute, Seattle, Washington

    Locations

    2 in total

    Run by

    Seattle Children's Hospital

    See if you can join NCT07097792 on ClinicalTrials.gov

24. Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)

    The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training" (RS-tDCS+) which has shown promise for improving complex attention in both he…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Naval Medical Center San Diego, San Diego, California

    Locations

    2 in total

    Run by

    United States Naval Medical Center, San Diego

    See if you can join NCT06413173 on ClinicalTrials.gov

25. Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

    This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effec…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    SUNY Upstate Medical University, Syracuse, New York

    Run by

    State University of New York - Upstate Medical University

    See if you can join NCT06112093 on ClinicalTrials.gov