Migraine Clinical Trials

40 studies are recruiting for migraine in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to Rimegepant

   The purpose of the study is to evaluate fetal, maternal, and infant outcomes through 12 months of age.

   Stage

   Not phased

   Ages

   0 and older

   Site

   Evidera, a PPD business unit, Wilmington, North Carolina

   Run by

   Pfizer

   See if you can join NCT05046613 on ClinicalTrials.gov

2. Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

   Exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. The study aims to evaluate the effectiveness of endoscopically-guided injection of Exparel (Bupivacaine) for the treatment of craniofacial pain. This study would be conduct…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Peter H Hwang, Stanford, California

   Run by

   Stanford University

   See if you can join NCT04930887 on ClinicalTrials.gov

3. External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

   This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. …

   Stage

   Not phased

   Ages

   18 to 44

   Site

   https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut

   Run by

   Cefaly Technology

   See if you can join NCT06788977 on ClinicalTrials.gov

4. Stimulation of External Carotid Artery Circulation

   This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches. The goal of the study is to determine whether this appro…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Texas Medical Branch, Galveston, Texas

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07402954 on ClinicalTrials.gov

5. Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks

   Migraine is a neurological disease characterized by moderate or severe headaches, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will assess changes in migraine attack severity for adult participants treating with oral ubrogepant across migraine attacks. Ubrogep…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Neurology and Pain Specialty Center /ID# 278508, Aliso Viejo, California

   Locations

   3 in total

   Run by

   AbbVie

   See if you can join NCT07310290 on ClinicalTrials.gov

6. Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

   The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Advocate Christ Medical Center Emergency Department, Oak Lawn, Illinois

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT06904287 on ClinicalTrials.gov

7. Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

   The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * …

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06961864 on ClinicalTrials.gov

8. Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

   Single-center, open label, prospective study conducted at Medstar Georgetown Headache Center. Men and woman ≥ 18 years old that are diagnosed with migraine with or without aura for at least 1 year, who report a reliable migraine trigger. Acceptable triggers for the study will include exercise, alco…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   MedStar Health: Neurology at McLean, McLean, Virginia

   Run by

   Medstar Health Research Institute

   See if you can join NCT07301008 on ClinicalTrials.gov

9. Observational Study to Assess Adverse Events When Adult Female Participants Are Treated With Ubrelvy (Ubrogepant) or Qulipta (Atogepant) During Pregnancy

   Migraine is a common neurological disorder typically characterized by attacks of throbbing or pulsating headache on one side of the head of moderate to severe pain intensity. The purpose of this study is to evaluate fetal, maternal, and infant outcomes through 12 months of age among women exposed t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Iqvia /Id# 266904, Durham, North Carolina

   Locations

   2 in total

   Run by

   AbbVie

   See if you can join NCT05158894 on ClinicalTrials.gov

10. Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

    This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI). The study will be conducted at the National Intrepid Center of Excellence (NICOE) i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National Intrepid Center of Excellence (NICOE), Bethesda, Maryland

    Run by

    Uniformed Services University of the Health Sciences

    See if you can join NCT07267819 on ClinicalTrials.gov

11. Aimovig Pregnancy Exposure Registry

    The primary objective of this study is to estimate the proportion of major congenital malformations in infants of women with migraine exposed to erenumab-aooe during pregnancy compared to infants of women with migraine unexposed to erenumeb-aooe.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    IQVIA Virtual Site, Durham, North Carolina

    Run by

    Amgen

    See if you can join NCT06150781 on ClinicalTrials.gov

12. RELAXaHEAD for Headache Patients (Phase III)

    This study is a fully powered, remote randomized control trial to evaluate RELAXaHEAD in people with migraine.

    Stage

    Not phased

    Ages

    16 to 80

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06077838 on ClinicalTrials.gov

13. A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache

    Rimegepant (Nurtec) is an orally administered small molecule CGRP receptor antagonist with efficacy in the acute treatment of migraine. Rizatriptan benzoate (MAXALT), is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Rizatriptan binds with high affinity to human cloned 5-HT1B an…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Maimonides Medical Center, Brooklyn, New York

    Run by

    Antonios Likourezos

    See if you can join NCT06473597 on ClinicalTrials.gov

14. Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

    The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies (erenumab, galcanezumab, fremanezumab, eptinezumab) or gepants (rimegepant, …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miller School of Medicine, Miami, Florida

    Locations

    26 in total

    Run by

    Hospital Universitari Vall d'Hebron Research Institute

    See if you can join NCT07159750 on ClinicalTrials.gov

15. Overlapping Pain Trajectory Study

    The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1. If spatial and temporal filtering of nociceptive information is disrupted in youth with COP…

    Stage

    Not phased

    Ages

    10 to 19

    Site

    Cincinnati Children's Hospital, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05752396 on ClinicalTrials.gov