Migraine Clinical Trials

42 studies are recruiting for migraine in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Endometriosis and Migraine

   This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples…

   Stage

   Not phased

   Ages

   12 to 45

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06785129 on ClinicalTrials.gov

2. BE WELL With Migraine: Brain Education and WELLness With Migraine

   The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Locations

   3 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT05987592 on ClinicalTrials.gov

3. Determining the Utility of a Behavioral Intervention in Chronic Migraine

   This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protoc…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Phoenix, Arizona

   Run by

   Mayo Clinic

   See if you can join NCT05415020 on ClinicalTrials.gov

4. A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine

   The goal of this clinical trial is to learn whether a home-based virtual reality (VR) neurofeedback program is feasible and acceptable for adolescents with migraine. The study will also explore whether the program may improve headache-related outcomes. The main questions it aims to answer are: Is i…

   Stage

   Not phased

   Ages

   10 to 16

   Site

   Children's Mercy, Kansas City, Missouri

   Run by

   Children's Mercy Hospital Kansas City

   See if you can join NCT07454798 on ClinicalTrials.gov

5. Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

   The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain receptors, potentially leading to improvements in chronic migraine intensity,…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Neuroscience Institute at Great Neck, Great Neck, New York

   Run by

   Northwell Health

   See if you can join NCT07061847 on ClinicalTrials.gov

6. Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

   For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standar…

   Stage

   EARLY_Phase 1

   Ages

   18 to 85

   Site

   University Medical Center of El Paso, El Paso, Texas

   Run by

   Texas Tech University Health Sciences Center, El Paso

   See if you can join NCT06016465 on ClinicalTrials.gov

7. Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

   Exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. The study aims to evaluate the effectiveness of endoscopically-guided injection of Exparel (Bupivacaine) for the treatment of craniofacial pain. This study would be conduct…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Peter H Hwang, Stanford, California

   Run by

   Stanford University

   See if you can join NCT04930887 on ClinicalTrials.gov

8. External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

   This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. …

   Stage

   Not phased

   Ages

   18 to 44

   Site

   https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut

   Run by

   Cefaly Technology

   See if you can join NCT06788977 on ClinicalTrials.gov

9. Stimulation of External Carotid Artery Circulation

   This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches. The goal of the study is to determine whether this appro…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Texas Medical Branch, Galveston, Texas

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07402954 on ClinicalTrials.gov

10. Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks

    Migraine is a neurological disease characterized by moderate or severe headaches, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will assess changes in migraine attack severity for adult participants treating with oral ubrogepant across migraine attacks. Ubrogep…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Neurology and Pain Specialty Center /ID# 278508, Aliso Viejo, California

    Locations

    3 in total

    Run by

    AbbVie

    See if you can join NCT07310290 on ClinicalTrials.gov

11. Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

    The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Advocate Christ Medical Center Emergency Department, Oak Lawn, Illinois

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06904287 on ClinicalTrials.gov

12. Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

    The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * …

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06961864 on ClinicalTrials.gov

13. Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

    Single-center, open label, prospective study conducted at Medstar Georgetown Headache Center. Men and woman ≥ 18 years old that are diagnosed with migraine with or without aura for at least 1 year, who report a reliable migraine trigger. Acceptable triggers for the study will include exercise, alco…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    MedStar Health: Neurology at McLean, McLean, Virginia

    Run by

    Medstar Health Research Institute

    See if you can join NCT07301008 on ClinicalTrials.gov

14. Observational Study to Assess Adverse Events When Adult Female Participants Are Treated With Ubrelvy (Ubrogepant) or Qulipta (Atogepant) During Pregnancy

    Migraine is a common neurological disorder typically characterized by attacks of throbbing or pulsating headache on one side of the head of moderate to severe pain intensity. The purpose of this study is to evaluate fetal, maternal, and infant outcomes through 12 months of age among women exposed t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Iqvia /Id# 266904, Durham, North Carolina

    Locations

    2 in total

    Run by

    AbbVie

    See if you can join NCT05158894 on ClinicalTrials.gov

15. Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

    This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI). The study will be conducted at the National Intrepid Center of Excellence (NICOE) i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National Intrepid Center of Excellence (NICOE), Bethesda, Maryland

    Run by

    Uniformed Services University of the Health Sciences

    See if you can join NCT07267819 on ClinicalTrials.gov

16. Aimovig Pregnancy Exposure Registry

    The primary objective of this study is to estimate the proportion of major congenital malformations in infants of women with migraine exposed to erenumab-aooe during pregnancy compared to infants of women with migraine unexposed to erenumeb-aooe.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    IQVIA Virtual Site, Durham, North Carolina

    Run by

    Amgen

    See if you can join NCT06150781 on ClinicalTrials.gov

17. Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

    The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies (erenumab, galcanezumab, fremanezumab, eptinezumab) or gepants (rimegepant, …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miller School of Medicine, Miami, Florida

    Locations

    26 in total

    Run by

    Hospital Universitari Vall d'Hebron Research Institute

    See if you can join NCT07159750 on ClinicalTrials.gov