Migraine Clinical Trials

40 studies are recruiting for migraine in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications

   Zavegepant (Zavzpret) is approved for the acute treatment of migraine with or without aura in the US. The purpose of this study is to investigate the effectiveness and tolerability of zavegepant for the acute treatment of migraine attacks amongst participants who are using calcitonin gene-related p…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Mayo Clinic in Arizona, Phoenix, Arizona

   Run by

   Mayo Clinic

   See if you can join NCT06401642 on ClinicalTrials.gov

2. Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

   This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerab…

   Stage

   Phase 4

   Ages

   18 to 70

   Site

   Northern Arizona Healthcare, Flagstaff, Arizona

   Locations

   36 in total

   Run by

   Mayo Clinic

   See if you can join NCT06972056 on ClinicalTrials.gov

3. Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

   Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and sound. Migraine is extremely common and disabling in children. The purpose of this study is to evaluate how s…

   Stage

   Phase 3

   Ages

   6 to 17

   Site

   Rehabilitation & Neurological Services /ID# 229969, Huntsville, Alabama

   Locations

   129 in total

   Run by

   AbbVie

   See if you can join NCT05125302 on ClinicalTrials.gov

4. Objectively Diagnose and Monitor Treatment of Light Sensitivity

   The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Iowa Health Care, Iowa City, Iowa

   Run by

   Randy Kardon

   See if you can join NCT03694626 on ClinicalTrials.gov

5. Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine

   This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Johns Hopkins Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07223008 on ClinicalTrials.gov

6. Study of EVO756 in Adults With Migraine

   This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.

   Stage

   Phase 2

   Ages

   18 to 64

   Site

   Trialsphere Corp, Chandler, Arizona

   Locations

   26 in total

   Run by

   Evommune, Inc.

   See if you can join NCT07616128 on ClinicalTrials.gov

7. Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients

   This study is testing an investigational inhaled migraine medication to see how well it works, how safe it is, and how well people tolerate it. Adults with migraine will receive both the study medication (ASY202) and a placebo (inactive treatment) at different times during the study. Neither partic…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Sunwise Clinical Research, Llc, Walnut Creek, California

   Locations

   6 in total

   Run by

   Aspeya, Inc.

   See if you can join NCT07646613 on ClinicalTrials.gov

8. Responding With Evidence and Access for Childhood Headaches

   This comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for yo…

   Stage

   Not phased

   Ages

   10 to 17

   Site

   University of Alabama at Birmingham Children's of Alabama, Birmingham, Alabama

   Locations

   15 in total

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT05889624 on ClinicalTrials.gov

9. Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

   The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to <18 years with episodic migraine.

   Stage

   Phase 3

   Ages

   6 to 17

   Site

   Advanced Investigative Medicine, Inc., Hawthorne, California

   Locations

   93 in total

   Run by

   Pfizer

   See if you can join NCT05156398 on ClinicalTrials.gov

10. A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

    This is a double-blind, randomized, multicenter, outpatient evaluation of the efficacy, safety, and tolerability of elismetrep, as compared with placebo, in the acute treatment of migraine.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Central Research Associates, LLC (CRA) dba Flourish Research, Birmingham, Alabama

    Locations

    113 in total

    Run by

    Kallyope Inc.

    See if you can join NCT07645924 on ClinicalTrials.gov

11. NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

    Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances. In this natural history study, researchers would like to learn more about the connection between exercise and m…

    Stage

    Not phased

    Ages

    8 to 70

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT05669703 on ClinicalTrials.gov

12. Emgality for Migraine in Breastmilk

    The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who …

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06085144 on ClinicalTrials.gov

13. Headache Ear Auditory Dizziness Sinus (HEADS) Registry

    The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms. Through an online portal, participants are asked questions about their symptoms, how they have affected t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Association of Migraine Disorders, North Kingstown, Rhode Island

    Run by

    Association of Migraine Disorders

    See if you can join NCT07754266 on ClinicalTrials.gov

14. Migraine in Adolescents

    Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes precedi…

    Stage

    Not phased

    Ages

    10 to 13

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05654012 on ClinicalTrials.gov

15. Mechanistic Studies of Psilocybin in Headache Disorders

    In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect. This study will measure brain resting state functional connectivity (fMRI), cent…

    Stage

    EARLY_Phase 1

    Ages

    21 to 70

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06464367 on ClinicalTrials.gov

16. Endometriosis and Migraine

    This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples…

    Stage

    Not phased

    Ages

    12 to 45

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06785129 on ClinicalTrials.gov

17. Cocoa Extract for Migraine Trial

    The goal of this clinical trial is to assess the feasibility of recruitment and adherence to a high-dose cocoa extract supplement in individuals diagnosed with episodic migraine. The main questions it aims to answer are: * Will we be able to enroll 114 participants during the recruitment period? * …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06808230 on ClinicalTrials.gov

18. Mind Body Balance for Pediatric Migraine

    This study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.

    Stage

    Not phased

    Ages

    10 to 17

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Locations

    2 in total

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT04715685 on ClinicalTrials.gov

19. A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

    The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.

    Stage

    Phase 3

    Ages

    6 to 17

    Site

    Yale University School of Medicine, New Haven, Connecticut

    Locations

    70 in total

    Run by

    H. Lundbeck A/S

    See if you can join NCT05164172 on ClinicalTrials.gov

20. BE WELL With Migraine: Brain Education and WELLness With Migraine

    The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Locations

    3 in total

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05987592 on ClinicalTrials.gov

21. Determining the Utility of a Behavioral Intervention in Chronic Migraine

    This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protoc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Run by

    Mayo Clinic

    See if you can join NCT05415020 on ClinicalTrials.gov

22. A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine

    The goal of this clinical trial is to learn whether a home-based virtual reality (VR) neurofeedback program is feasible and acceptable for adolescents with migraine. The study will also explore whether the program may improve headache-related outcomes. The main questions it aims to answer are: Is i…

    Stage

    Not phased

    Ages

    10 to 16

    Site

    Children's Mercy, Kansas City, Missouri

    Run by

    Children's Mercy Hospital Kansas City

    See if you can join NCT07454798 on ClinicalTrials.gov

23. Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

    The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain receptors, potentially leading to improvements in chronic migraine intensity,…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Neuroscience Institute at Great Neck, Great Neck, New York

    Run by

    Northwell Health

    See if you can join NCT07061847 on ClinicalTrials.gov

24. A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

    The purpose of this Phase 2 study is to evaluate the safety and efficacy of SC MEDI0618 compared to placebo in participants with episodic migraine.

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Flourish - Birmingham, Birmingham, Alabama

    Locations

    54 in total

    Run by

    AbbVie

    See if you can join NCT06602479 on ClinicalTrials.gov

25. Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

    For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standar…

    Stage

    EARLY_Phase 1

    Ages

    18 to 85

    Site

    University Medical Center of El Paso, El Paso, Texas

    Run by

    Texas Tech University Health Sciences Center, El Paso

    See if you can join NCT06016465 on ClinicalTrials.gov