Lung Cancer Clinical Trials

149 studies are recruiting for lung cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

   This is a multicenter, open-label, Phase 1/2 study of orally administered VMD-928 monotherapy and in combination with pembrolizumab in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curat…

   Stage

   Phase 1

   Ages

   18 to 80

   Site

   Providence Medical Foundation (site 209), Santa Rosa, California

   Locations

   15 in total

   Run by

   VM Oncology, LLC

   See if you can join NCT03556228 on ClinicalTrials.gov

2. Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer

   This study will prospectively collect airway, stool, and blood samples on 80 subjects with lung cancer undergoing immunotherapy. Investigators will evaluate airway/stool microbial signatures associated with local (lower airway) and systemic (blood) immune tone.They will then study whether microbiot…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT04063501 on ClinicalTrials.gov

3. Image Guided VATS vs. VATS Resection

   To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT03623958 on ClinicalTrials.gov

4. Stereotactic Magnetic Resonance Guided Radiation Therapy

   This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer. * The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with cancer. * Ph…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham & Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT04115254 on ClinicalTrials.gov

5. Detection of Genetic Markers of Lung Cancer

   The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hillman Cancer Center, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT00280202 on ClinicalTrials.gov

6. Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery

   The purpose of the study is to explore adding the study drug certolizumab to standard chemotherapy as it may reduce the inflammation caused by the cancer and make the chemotherapy more effective in shrinking the cancer. This study will examine whether adding certolizumab to the usual treatment appr…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Memorial Sloan Kettering at Basking Ridge Limited Protocol Activities, Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT04991025 on ClinicalTrials.gov

7. UNC Pleural Fluid Registry

   Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UNC Lingeberger Comprehensive Cancer Center, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT05620329 on ClinicalTrials.gov

8. Health Opportunities and Promoters of Equitable Screening for Lung Cancer

   The goal of this clinical trial is to promote lung cancer screening (LCS) uptake among Hispanic current and former smokers. The main questions it aims to answer are: * What barriers do current and former Hispanic smokers face in the identification and documentation of their smoking status? * How ca…

   Stage

   Not phased

   Ages

   50 to 80

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05784922 on ClinicalTrials.gov

9. Prospective Study to Evaluate High Flow Nasal Cannula With Monitored Anesthesia Care During EBUS Bronchoscopy

   Our objective is to assess whether the use of high flow nasal cannula (Vapotherm, Exeter, NH) with monitored anesthesia care (MAC) during an endobronchial ultrasound (EBUS) bronchoscopy procedure will lead to less procedure interruptions, less hypoxic episodes, shorter duration of hypoxic episodes …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cooper University Hospital, Camden, New Jersey

   Run by

   The Cooper Health System

   See if you can join NCT05203328 on ClinicalTrials.gov

10. Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

    RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patie…

    Stage

    Not phased

    Ages

    21 to 90

    Site

    University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT00900419 on ClinicalTrials.gov

11. A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

    The goal of this study is to test A2B395, an allogeneic logic-gated Tmod™ CAR T-cell product in subjects with solid tumors including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), triple-negative breast cancer (TNBC), renal cell carcinoma…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Banner MD Anderson Cancer Center, Gilbert, Arizona

    Locations

    10 in total

    Run by

    A2 Biotherapeutics Inc.

    See if you can join NCT06682793 on ClinicalTrials.gov

12. PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification

    In this Project, we will use therapeutic target -focused (TTF) profiling, genome-wide mRNA profiling and assessments of tumor phosphopeptides and DNA that are shed into the blood stream to define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    M D Anderson Caner Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05049837 on ClinicalTrials.gov

13. Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

    This is a single-armed screening research study which screens immediate family member of lung cancer patients with a driver mutation to see if lung cancer can be inherited and whether researchers can find lung cancer early. Immediate family members of lung cancer patients will be 40-80 years old an…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Chao Family Comprehensive Cancer Center University of California, Irvine, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT07062172 on ClinicalTrials.gov

14. APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

    To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CNS tumors harboring MET alterations, solid tumors harboring w…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California

    Locations

    35 in total

    Run by

    Apollomics Inc.

    See if you can join NCT03175224 on ClinicalTrials.gov

15. Feasibility Study to Treat Lung Cancer With the Permanently Implantable LDR CivaSheet®

    This is a feasibility study to determine the usefulness of a brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration, which may benefit lung cancer patients by reducing the radiation dose to critical structures, such as the heart wall, while…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    CivaTech Oncology

    See if you can join NCT03290534 on ClinicalTrials.gov

16. Collection of Sputum and Labeling for Lung Cancer

    The primary objective of this study is to compare Assay results to diagnoses determined by currently accepted standards for lung cancer detection. This will be accomplished by analysis of sputum samples from three cohorts including healthy Participants, high risk Participants, and cancer patient Pa…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Atlantic Respiratory Institute, Summit, New Jersey

    Locations

    3 in total

    Run by

    bioAffinity Technologies Inc.

    See if you can join NCT03457415 on ClinicalTrials.gov

17. A Patient and Provider Intervention to Address Health Disparities in Lung Cancer Screening

    To test the impact of a multilevel intervention on primary (provider-patient communication, intentions, and knowledge) and secondary (screening referrals and completion) outcomes.

    Stage

    Not phased

    Ages

    50 to 80

    Site

    MedStar Health, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT04675476 on ClinicalTrials.gov

18. Comprehensive Outcomes for After Cancer Health

    This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer. Up to 625 individuals with diverse cancer diagnoses will be enrolled across up to 8 clinical sites to pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Locations

    7 in total

    Run by

    Pack Health

    See if you can join NCT05349227 on ClinicalTrials.gov

19. DNA Analysis of Blood and Tissue from Patients with Lung Cancer

    RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is analyzing the DNA in…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT00471978 on ClinicalTrials.gov

20. Molecular and Genetic Analysis of Lung Cancer

    Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT03029325 on ClinicalTrials.gov

21. DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies

    This is a prospective observational registration trial for patients who undergo lung transplantation for the treatment of the select groups of medically refractory cancers affecting the lungs alone without extrapulmonary nodal and distant metastasis.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Thoracic Surgery, Canning Thoracic Institute (Northwestern Memorial Hospital), Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT05671887 on ClinicalTrials.gov

22. Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

    The goal of this observational study is to learn how a physician uses the results of the Percepta® Nasal Swab test to manage people with a newly identified pulmonary nodule. The main questions it aims to answer are: * Does the use of the Percepta Nasal swab test reduce the number of invasive proced…

    Stage

    Not phased

    Ages

    29 to 85

    Site

    Trinity Health Of New England, Hartford, Connecticut

    Locations

    23 in total

    Run by

    Veracyte, Inc.

    See if you can join NCT06426628 on ClinicalTrials.gov

23. Next Generation Chest X-Ray Tomosynthesis for Screening of Lung Cancer

    The goal of this observational clinical trial is to learn if chest tomosynthesis is a potential alternative to computed tomography for the detection of lung cancer. It will also develop artificial intelligence tools to aid in the diagnosis of lung cancer on chest tomosynthesis images. The main ques…

    Stage

    Not phased

    Ages

    30 to 85

    Site

    University of California San Diego, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06577883 on ClinicalTrials.gov

24. Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC

    To test whether it is feasible to perform the 3D-EX functional predictive response bioassay in the context of patients with advanced/metastatic NSCLC receiving immune checkpoint inhibitors in the standard of care clinical setting.

    Stage

    Not phased

    Ages

    18 to 110

    Site

    The University of Kansas Cancer Center (KUCC), Fairway, Kansas

    Locations

    2 in total

    Run by

    Jun Zhang, MD, PhD

    See if you can join NCT05332925 on ClinicalTrials.gov