Lung Cancer Clinical Trials in Boston, Massachusetts

29 studies are recruiting for lung cancer in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. A Registry for People With Lung Cancer

    Participants will complete questionnaires before surgery, between 2 to 4 weeks after surgery, and 6 months after surgery.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital Cancer Center (Data Collection Only), Boston, Massachusetts
    Locations
    19 in total
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06424327 on ClinicalTrials.gov

  2. The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

    The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C mutation. The Phase 1 portion of the study will assess the safety, toler…

    Stage
    Phase 1
    Ages
    12 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    77 in total
    Run by
    PMV Pharmaceuticals, Inc

    See if you can join NCT04585750 on ClinicalTrials.gov

  3. Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

    The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-M07D1 in patients with HER2 expressing advanced tumors.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Dana Farber Cancer Institute, Boston, Massachusetts
    Locations
    26 in total
    Run by
    SystImmune Inc.

    See if you can join NCT06293898 on ClinicalTrials.gov

  4. Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

    The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patients with brain metastases that are more difficult to control with stereotactic radiation alone.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT04899908 on ClinicalTrials.gov

  5. Investigating Hereditary Risk In Thoracic Cancers (INHERIT)

    The purpose of this research study is to learn more about the inherited risk for developing lung cancer.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dana-Farber Cancer Institute, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT05587439 on ClinicalTrials.gov

  6. InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

    This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The …

    Stage
    Not phased
    Ages
    Any age
    Site
    Dana Farber Cancer Institute, Boston, Massachusetts
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT05463796 on ClinicalTrials.gov

  7. Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial

    The purpose of this study is to examine the feasibility and effects of 12-week exercise training at different intensities among individuals with advanced lung cancer receiving immune checkpoint inhibitors. The names of the study interventions involved in this study are: * High-intensity interval tr…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dana-Farber Cancer Institute, Boston, Massachusetts
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT06026111 on ClinicalTrials.gov

  8. Distance-Based Exercise to Preserve Function and Prevent Disability

    This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side e…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dana-Farber Cancer Institute, Boston, Massachusetts
    Locations
    18 in total
    Run by
    Alliance for Clinical Trials in Oncology

    See if you can join NCT07059884 on ClinicalTrials.gov

  9. Precise Exercise Regimen for Cancer Care (PERCC): A Pilot Study

    The purpose of this study is to test the feasibility of the Precise Exercise Regimen for Cancer Care (PERCC) exercise program in participants with stage II-III primary lung cancer.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dana-Farber Cancer Institute, Boston, Massachusetts
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT07412041 on ClinicalTrials.gov

  10. EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

    This research study is studying a new blood test to screen for Epidermal Growth Factor Receptor (EGFR) positive lung cancer in healthy individuals at risk for the disease and who cannot undergo regular lung cancer screening. The name of the test used in this research study is: -Circulating free DNA…

    Stage
    Not phased
    Ages
    40 to 80
    Site
    Dana-Farber Cancer Institute, Boston, Massachusetts
    Locations
    6 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT06716580 on ClinicalTrials.gov

  11. Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer

    Multi-site randomized trial of the THRIVE digital health application versus usual care to evaluate the effect of THRIVE on quality of life (QOL), physical and psychological symptoms, coping, and self-efficacy in 250 patients with newly diagnosed advanced lung cancer.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    3 in total
    Run by
    Massachusetts General Hospital

    See if you can join NCT06427954 on ClinicalTrials.gov

  12. Prediction Augmented Screening Initiative

    Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans. This is because lung cancer is usually diagnosed when the disease has spread, and cure is less likely. Lung cancer screening (LCS) finds c…

    Stage
    Not phased
    Ages
    50 to 80
    Site
    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
    Locations
    4 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT06538636 on ClinicalTrials.gov

  13. Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

    TNG462-C102 is a Phase 1/2, open-label, multicenter study designed to determine the safety, tolerability, PK, PD, and preliminary antineoplastic activity of oral TNG462 in combination with RMC-6236, RMC-9805, mFOLFIRINOX or gemcitabine/nab-paclitaxel. The study comprises a dose escalation phase and…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    18 in total
    Run by
    Tango Therapeutics, Inc.

    See if you can join NCT06922591 on ClinicalTrials.gov

  14. Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT

    The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation. The main question it aims to answer is: Does the AI tool improve lung cancer …

    Stage
    Not phased
    Ages
    50 to 77
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT06910956 on ClinicalTrials.gov

  15. Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

    This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP loss. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific solid tum…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Dana Farber Cancer Institute, Boston, Massachusetts
    Locations
    15 in total
    Run by
    Tango Therapeutics, Inc.

    See if you can join NCT06810544 on ClinicalTrials.gov

  16. Avecure Flexible Microwave Ablation Probe For Lung Nodules

    This research study to determine the effectiveness of the AveCure Flexible Microwave Ablation Probe to destroy cancerous lung nodules up to 3 c m in size. This research study involves microwave ablation (MWA)

    Stage
    Not phased
    Ages
    22 and older
    Site
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT05281237 on ClinicalTrials.gov

  17. Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

    Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist. Developing a standardized technique to dissect the lobectomy specimen has the potential of maximizing…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Womens Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06252129 on ClinicalTrials.gov

  18. Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

    The goal of this study is to investigate the safety of [68Ga]CBP8 and its efficacy to detect collagen deposition in pulmonary fibrosis.

    Stage
    Phase 1
    Ages
    18 to 80
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT03535545 on ClinicalTrials.gov

  19. Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

    The goal of this study is to investigate the efficacy of [68Ga]CBP8 to detect collagen deposition in radiation induced tissue injury.

    Stage
    Phase 2
    Ages
    18 to 80
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT04485286 on ClinicalTrials.gov

  20. Lung Cancer Screening in High-risk Black Individuals

    The goal of this research study is to study U.S. Black individuals with a history of smoking to examine the feasibility, acceptability, and performance of low-dose computed tomography (LDCT) screening among this population. The name of the intervention used in this research study is: Low-dose compu…

    Stage
    Not phased
    Ages
    50 to 80
    Site
    Massachusetts General Hospital Cancer Center, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Massachusetts General Hospital

    See if you can join NCT05898594 on ClinicalTrials.gov

  21. Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

    The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-B01D1 in patients with Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    39 in total
    Run by
    SystImmune Inc.

    See if you can join NCT05983432 on ClinicalTrials.gov

  22. Image Guided VATS vs. VATS Resection

    To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT03623958 on ClinicalTrials.gov

  23. Stereotactic Magnetic Resonance Guided Radiation Therapy

    This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer. * The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with cancer. * Ph…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham & Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT04115254 on ClinicalTrials.gov

  24. Health Opportunities and Promoters of Equitable Screening for Lung Cancer

    The goal of this clinical trial is to promote lung cancer screening (LCS) uptake among Hispanic current and former smokers. The main questions it aims to answer are: * What barriers do current and former Hispanic smokers face in the identification and documentation of their smoking status? * How ca…

    Stage
    Not phased
    Ages
    50 to 80
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05784922 on ClinicalTrials.gov

  25. APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

    To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CNS tumors harboring MET alterations, solid tumors harboring w…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Dana Farber Cancer Institute, Boston, Massachusetts
    Locations
    35 in total
    Run by
    Apollomics Inc.

    See if you can join NCT03175224 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.