Lung Cancer Clinical Trials

149 studies are recruiting for lung cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. 4D-MRI for Precision Medicine

   The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breath…

   Stage

   Not phased

   Ages

   18 to 82

   Site

   University of Virginia, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT04657042 on ClinicalTrials.gov

2. Axelopran for Advanced Cancer in Patients Receiving Opioids

   The primary objective of this single arm, open label, phase II trial is to determine if axelopran use impacts cancer control in patients with advanced cancers of the lung, breast, pancreas, and prostate. The primary study period for assessing the primary aim is through day 43 (6 weeks). The main qu…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park, Minnesota

   Locations

   2 in total

   Run by

   HealthPartners Institute

   See if you can join NCT07354919 on ClinicalTrials.gov

3. Increasing Lung Cancer Screening Uptake Among Emergency Department Patients

   The objective of the proposed clinical trial is to determine if we can increase LCS among ED patients using a combination of facilitated referral to an LCS program plus text message reminders to get screened. Step 1 of the approach is to identify participants that are eligible for LCS. Step 2 is to…

   Stage

   Not phased

   Ages

   50 to 80

   Site

   University of Rochester, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT07287085 on ClinicalTrials.gov

4. Metabolic Biomarkers in Thoracic Cancers

   The purpose of this research study is to develop a method of using magnetic resonance imaging (MRI) to evaluate lung tumors and other thoracic malignancies. An MRI is a scanning device that uses magnets to make images (pictures) of the body. This study is being done to determine what series of reac…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT02095808 on ClinicalTrials.gov

5. ATATcH Alternating Treatment Plans for Advanced Cancer

   The purpose of the research is to evaluate a new schedule of alternating cycles of induction chemoimmunotherapy (chemotherapy plus pembrolizumab) and immunotherapy (pembrolizumab) alone for the initial treatment of patients with advanced lung or head and neck cancers.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Trinitas Hospital and Comprehensive Cancer Center, Elizabeth, New Jersey

   Locations

   11 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT05358548 on ClinicalTrials.gov

6. Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer

   RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk of cancer for laboratory studies may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at molecular predictors of…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Vanderbilt-Ingram Cancer Center, Nashville, Tennessee

   Locations

   2 in total

   Run by

   Vanderbilt-Ingram Cancer Center

   See if you can join NCT00898313 on ClinicalTrials.gov

7. Rural Illinois Lung Cancer Screening Initiative

   The role of this observational study is to access the feasibility of providing lung cancer screening using a designated nurse navigator through lung cancer screening clinic. Eligible participants will be identified using medical records, eligibility will be confirmed through phone call, screening v…

   Stage

   Not phased

   Ages

   50 to 80

   Site

   Sowmy Thuppal, Springfield, Illinois

   Run by

   Southern Illinois University

   See if you can join NCT06084078 on ClinicalTrials.gov

8. Multiparametric Image Analysis and Correlation With Outcomes in Lung Cancer Screening and Early Stage Lung Cancer

   Determine whether CT-based multiparametric analytical models may improve prediction of biopsy and treatment outcome in patients undergoing screening CT scan and/or treatment for early stage lung cancer

   Stage

   Not phased

   Ages

   18 to 99

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT03563976 on ClinicalTrials.gov

9. Registry Trial and Needs Assessment of Patients With Young-onset Lung Cancer: Impact of a Dedicated Care Program on Patient Experience and Outcomes

   The goal of this research study is to learn about: The effect of enrolling in the YOLC program on patient satisfaction with care provided, The needs of patients younger than 50 with lung cancer and their family, and The impact of participating in peer support networks on these patients.

   Stage

   Not phased

   Ages

   18 to 50

   Site

   The University of Texas M. D. Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT07220096 on ClinicalTrials.gov

10. Couple-Based Meditation for Metastatic Lung Cancer Patients and Their Partners

    Objectives: Our specific aims are to: Aim 1: Examine the feasibility of a couple-based meditation program in 50 patients with metastatic lung cancer and their partners. Aim 2: Establish the initial efficacy of a couple-based meditation program in patients and their partners regarding physical, psyc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Hermann, Houston, Texas

    Locations

    2 in total

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT02596490 on ClinicalTrials.gov

11. Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy

    The goal of this clinical trial is to learn if using an incentive spirometer can reduce lung problems in people with advanced lung cancer who are receiving chemotherapy and radiation therapy. The main questions the study aims to answer are: Does using an incentive spirometer lower the chances of de…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Anderson Cancer Center at Cooper, Camden, New Jersey

    Run by

    The Cooper Health System

    See if you can join NCT06688422 on ClinicalTrials.gov

12. Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

    This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP loss. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific solid tum…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic Scottsdale, Scottsdale, Arizona

    Locations

    15 in total

    Run by

    Tango Therapeutics, Inc.

    See if you can join NCT06810544 on ClinicalTrials.gov

13. Pulmonary Rehabilitation in Advanced Lung Cancer Survivors

    This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of t…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio

    Run by

    Case Comprehensive Cancer Center

    See if you can join NCT07104630 on ClinicalTrials.gov

14. Avecure Flexible Microwave Ablation Probe For Lung Nodules

    This research study to determine the effectiveness of the AveCure Flexible Microwave Ablation Probe to destroy cancerous lung nodules up to 3 c m in size. This research study involves microwave ablation (MWA)

    Stage

    Not phased

    Ages

    22 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT05281237 on ClinicalTrials.gov

15. Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements

    This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28 days. Subjects will receive alectinib twice daily. Those in the Phase 1b portion will receive alectinib alone. Those in Phase 2 Arm A will …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Stanford University, Stanford, California

    Locations

    3 in total

    Run by

    Joshua Palmer

    See if you can join NCT05987644 on ClinicalTrials.gov

16. Confocal Laser Endomicroscopy VERification

    The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the diagnostic yield in patients with peripheral pulmonary nodules suspect for m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Montefiore Medical Center, New York, New York

    Locations

    5 in total

    Run by

    Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

    See if you can join NCT06079970 on ClinicalTrials.gov

17. Personalized Accelerated ChEmoRadiation (PACER) for Lung Cancer

    The purpose of this study is to examine the use of hypofractionated accelerated radiation therapy (HART) to treat locally advanced lung cancer. Depending on the location and size of the tumor.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Stanford University, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT06080061 on ClinicalTrials.gov

18. The SENTINL-1 Study: Evaluating Patient-Reported Outcomes of AI-Inferred Lung Cancer Risk

    This is a two-cohort (screen naïve vs screen established), prospective, longitudinal, single-center clinical study design that will provide data to comprehensively evaluate patient-reported outcomes of Artificial Intelligence (AI) based prediction of an individual's risk of developing lung cancer o…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07458425 on ClinicalTrials.gov

19. Study of Trilaciclib and Lurbinectidin

    Lung cancer is by far the leading cause of cancer death among both men and women worldwide and the second most common cancer in terms of new cases. Small cell lung cancer (SCLC) is the deadliest form of lung cancer. The standard first-line treatment is the combination of carboplatin, etoposide, and…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center at University of North Carolina Chapel Hill, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT05578326 on ClinicalTrials.gov

20. Avera Cancer Sequencing and Analytics Protocol (ASAP)

    The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system. Through comprehensive genomic profiling, investigators aim to identify the underlying genomic drivers of premalignant …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Avera Cancer Institute - Marshall, Marshall, Minnesota

    Locations

    6 in total

    Run by

    Avera McKennan Hospital & University Health Center

    See if you can join NCT05142033 on ClinicalTrials.gov

21. A Mobile Patient Health Technology Intervention for Improving Lung Cancer Screening Rates in Eligible High Risk Patients

    To evaluate the real-world effectiveness and implementation strategies for mPATH-Lung, investigators propose a pragmatic, randomized controlled trial across an academic Learning Health System. The trial will contrast several approaches to participant outreach and will specifically target engaging f…

    Stage

    Not phased

    Ages

    50 to 77

    Site

    Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT07322367 on ClinicalTrials.gov

22. Accelerated Pulmonary Rehabilitation in the Preoperative Period

    This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with or without surgical resection will be recruited from the University o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Vermont Medical Center, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT06432972 on ClinicalTrials.gov

23. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

    The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Allegheny Health Network, Pittsburgh, Pennsylvania

    Locations

    18 in total

    Run by

    UMC Utrecht

    See if you can join NCT04075305 on ClinicalTrials.gov

24. Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

    Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist. Developing a standardized technique to dissect the lobectomy specimen has the potential of maximizing…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Womens Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06252129 on ClinicalTrials.gov

25. Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

    This this study is for individuals who have treatment-naïve extensive-stage small cell lung cancer (small cell lung cancer that wont respond to treatment). Doctors leading this study hope to learn if combining durvalumab, carboplatin and etoposide with hyofractionated ablative radiation therapy (ra…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Chicago Medicine, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Chicago

    See if you can join NCT05068232 on ClinicalTrials.gov