Low Back Pain Clinical Trials

30 studies are recruiting for low back pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Examination of Nociscan Impact on Low Back Pain Surgical Outcomes

   This study is looking into how useful NOCISCAN is. NOCISCAN is a software as a Service (SaaS) tool that uses Magnetic Resonance (MR) spectroscopy. Nociscan leverages MRS to noninvasively help physicians distinguish between painful and nonpainful discs in the lumbar spine. The randomized controlled …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Arizona, Phoenix, Arizona

   Locations

   10 in total

   Run by

   Aclarion

   See if you can join NCT06661850 on ClinicalTrials.gov

2. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

   The main purpose of this study is to test the safety and efficacy of study drug for the treatment of chronic low back pain (CLBP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Synexus Clinical Research US, Inc., Phoenix, Arizona

   Locations

   37 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07641504 on ClinicalTrials.gov

3. Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

   Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU). In addition, to compile real-world clinical outcomes in subjects with chronic, intractable low back and/o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Denver Back Pain Specialists, Greenwood, Colorado

   Locations

   7 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT07190807 on ClinicalTrials.gov

4. Comparing Yoga Nidra, Yoga, and Control Condition on Pain in Individuals With Chronic Low Back Pain

   Individuals with chronic low back pain will undergo a yoga, yoga nidra, and control condition on separate visits. Each visit, before and after the intervention, participants with rate their pain in response to heat stimuli, a sit to stand task, and questionnaires.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Central Florida, Orlando, Florida

   Run by

   University of Central Florida

   See if you can join NCT07543835 on ClinicalTrials.gov

5. Stratified Targeted Engagement From Primary Care to Physical Therapy (STEPPT)

   The goal of this clinical trial is to learn if a health system intervention called "Stratified Targeted Engagement from Primary Care to Physical Therapy (STEPPT)" can improve how often doctors refer Hispanic patients with spine pain to physical therapy (referral rate) and how often patients attend …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Family Health Centers of San Diego, San Diego, California

   Run by

   San Diego State University

   See if you can join NCT07290361 on ClinicalTrials.gov

6. Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

   The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions i…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05556902 on ClinicalTrials.gov

7. Biologic Injection For Adults With Lumbar Disc Herniation

   The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation. The main questions it aims to answer are: * Does the BMAC injection lead to…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NewYork-Presbyterian/Weill Cornell Medical Center, Manhattan, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT07386548 on ClinicalTrials.gov

8. Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain

   The purpose of this research study is to see how a mindfulness meditation-based intervention affects pain. Specifically, we are interested in understanding the pain-relieving brain mechanisms of mindfulness meditation-based therapy for patients with opioid-treated chronic low back pain.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of California, San Diego, La Jolla, California

   Locations

   2 in total

   Run by

   University of Utah

   See if you can join NCT05607381 on ClinicalTrials.gov

9. Biomechanical Validation of the Caregiver Assisted Transfer Technique Instrument

   As of 2020, 53 million Americans provide unpaid care to an individual with a disability. One commonly performed activity of daily living (ADL) provided by informal caregivers is assisted transfers, which requires moving an individual from one surface to another. Approximately 94% of informal caregi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

   Run by

   VA Office of Research and Development

   See if you can join NCT06013878 on ClinicalTrials.gov

10. Chronic Low Back Pain and Osteopathic Manipulation Treatment

    The goal of this clinical trial is to learn if adding Osteopathic Manipulative Therapy (OMT) to the usual medical care provided at the VA (usual VA care) improves treatment outcomes in individuals with chronic low back pain (CLBP). OMT is a set of hands-on techniques a doctor uses to move a patient…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Edward Hines, Jr. VA Hospital, PM&R Clinic, Hines, Illinois

    Run by

    Edward Hines Jr. VA Hospital

    See if you can join NCT07161661 on ClinicalTrials.gov

11. Dronabinol as an Adjunct for Reducing Pain

    This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol [dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    Michael E Debakey VA Medical Center, Houston, Texas

    Run by

    Christopher D. Verrico

    See if you can join NCT06454669 on ClinicalTrials.gov

12. Blood Flow Restriction Training as a Targeted Intervention for Rowers With Back Pain.

    The purpose of this graduate student research study is to compare the effects of low-load blood flow restriction training (LL-BFR) and heavy-load training (HLT) in high-volume rowers with mild low back pain or recurrent low back pain (LBP), aiming to determine whether LL-BFR offers a safer yet equa…

    Stage

    Not phased

    Ages

    13 to 20

    Site

    Loma Linda University, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT07130812 on ClinicalTrials.gov

13. COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIOURAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP: SLEEPFIT TRIAL

    This study aims to find out which lifestyle approach works best for people with chronic musculoskeletal pain (such as low back pain or hip/knee osteoarthritis) who also have poor sleep. Participants will be randomly assigned to one of three 12-month home-based programs: exercise, cognitive behavior…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Susan Wakil Health Building, Camperdown, New South Wales

    Locations

    4 in total

    Run by

    University of Sydney

    See if you can join NCT07532070 on ClinicalTrials.gov

14. Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

    This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by telephone two and seven days later. Patients will be randomized to receiv…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    Albert Einstein College of Medicine/Montefiore Medical Center - Weiler ED, The Bronx, New York

    Locations

    2 in total

    Run by

    Montefiore Medical Center

    See if you can join NCT05721027 on ClinicalTrials.gov

15. The Spine Phenome Project

    The goal of this observational trial is to compare the health history and motion capabilities of participants with low back pain disorders to participants with healthy spines. The main question[s] it aims to answer are to: 1. Primary outcomes of this research effort include composite measures that …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT05776771 on ClinicalTrials.gov

16. Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain

    This Study is for our continued study of the Thoracolumbar Fascia (TFL) in patients with and without low back pain by our experienced multidisciplinary team: Vincent Wang PhD, VT Biomedical Engineering \& Mechanics (BEAM). Albert J Kozar DO, FAOASM, R-MSK. P. Gunnar Brolinson, DO, FAOASM, FAOCFP. D…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Edward Via College of Osteopathic Medicine, Blacksburg, Virginia

    Run by

    Edward Via Virginia College of Osteopathic Medicine

    See if you can join NCT06818175 on ClinicalTrials.gov

17. Erector Spinae Plane Block for Acute Back Pain in the Emergency Department

    The goal of this clinical trial is to learn if an erector spinae plane block (ESPB; a type of nerve block) works to reduce pain in adults presenting to the emergency department with low back pain. It will also learn if the ESPB reduces pain, disability, and return to work at 7 days. The main questi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06745453 on ClinicalTrials.gov

18. Time to BBVNA Relief

    Basivertebral nerve ablation (BVNA) is a minimally invasive procedure approved for vertebrogenic low back pain. While early studies support its efficacy, real-world evidence is still evolving, particularly regarding the trajectory of pain relief and functional improvement over time, and predictors …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale Spine and Pain Center - Guilford, Guilford, Connecticut

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT07433634 on ClinicalTrials.gov

19. AuriculoTherapy NeuroImaging

    This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. There are 4 total study visits, divided into two pairs of visits that occur …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Keith M Vogt

    See if you can join NCT06825390 on ClinicalTrials.gov

20. Perspectives on Spinal Manipulative Therapy for Low Back Pain

    The goal of this study is to better understand how the thoughts and beliefs of patients with low back pain and their physical therapist influence how much patients benefit from physical therapy. Participants will receive physical therapy as determined by their physical therapist including spinal ma…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06590116 on ClinicalTrials.gov

21. A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy

    This is a multi-site feasibility trial of an embedded emergency department (ED) physical therapy care model for low back pain at two EDs in the Northwestern Medicine and University of Utah Health systems. The study intervention (embedded ED physical therapy) is a reconceptualization of the traditio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern Memorial Hospital, Chicago, Illinois

    Locations

    2 in total

    Run by

    Northwestern University

    See if you can join NCT07224945 on ClinicalTrials.gov

22. Ischemic Preconditioning in Osteoarthritis and Back Pain

    We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

    Stage

    Not phased

    Ages

    50 and older

    Site

    Human and Sport Performance Lab, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07003113 on ClinicalTrials.gov

23. Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain

    The long-term objective of this investigation is to identify how Qigong affects brain function in brain areas relevant to patients with chronic low back pain (cLBP), thereby setting a foundation from which to perform further clinical research.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Children's Rehabilitation Center, 426 Church Street SE Room 302 - Brain Body Mind Lab Minneapolis, MN 55455, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04164225 on ClinicalTrials.gov

24. Endogenous Opioid Response to Injections

    This study will study pain relief after spine injections that are used to guide care. Some improvements in pain from a procedure might be from placebo effect rather than the physiological effect of the procedure. The study will use naloxone to reverse the effect of the body's internal placebo syste…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    VA Tennessee Valley Healthcare System, Nashville, Tennessee

    Run by

    Middle Tennessee Research Institute

    See if you can join NCT06666621 on ClinicalTrials.gov

25. Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?

    Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or i…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Brooke Army Medical Center, Fort Sam Houston, Texas

    Run by

    Brooke Army Medical Center

    See if you can join NCT06544525 on ClinicalTrials.gov